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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 36, 2006 - Issue 2
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Original Articles

Synthesis and Evaluation of Substituted Pyrazoles: Potential Antimalarials Targeting the Enoyl‐ACP Reductase of Plasmodium Falciparum

Sanjay Kumar Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India
,
Gyanendra Kumar Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India
,
Mili Kapoor Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India
,
Avadhesha Surolia Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India
&
Namita Surolia Molecular Biology and Genetics Unit, Jawaharlal Nehru Center for Advanced Scientific Research, Jakkur, Bangalore, IndiaCorrespondence[email protected]
Pages 215-226 | Received 11 Jul 2005, Published online: 15 Aug 2006

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HemantS. Chandak, NitinP. Lad & DipaliS. Dange. (2012) Greener and facile aqueous synthesis of pyrazoles using Amberlyst-70 as a recyclable catalyst. Green Chemistry Letters and Reviews 5:2, pages 135-138.
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Articles from other publishers (22)

Sandeep S. Kahandal, Anand S. Burange & Thomson A. Fernandes. (2023) Revisiting the role of sulfated oxides for the synthesis of pharmaceutically important heterocycles: Understanding, challenges, and future prospects. Tetrahedron Green Chem 2, pages 100031.
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Lekkala Ravindar, Siti Aishah Hasbullah, K.P. Rakesh & Nurul Izzaty Hassan. (2023) Pyrazole and pyrazoline derivatives as antimalarial agents: A key review. European Journal of Pharmaceutical Sciences 183, pages 106365.
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Dipanjan Karati, Kakasaheb Ramoo Mahadik, Piyush Trivedi & Dileep Kumar. (2022) A Molecular Insight into Pyrazole Congeners as Antimicrobial, Anticancer, and Antimalarial Agents. Medicinal Chemistry 18:10, pages 1044-1059.
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A. Demet DEMİRAG, Sefa ÇELİK, Berkant İLGİN, Ayşen ÖZEL & Sevim AKYÜZ. (2022) Clarification Of The Structure Of 1,4-Bis(2-Chloro-4-Nitrophenyl)Piperazine Molecule And Its Molecular Docking Analysis With DNA1,4-Bis(2-Kloro-4-Nitrofenil)Piperazin Molekülünün Yapısının Aydınlatılması ve DNA ile Moleküler Kenetlenme Analizi. Bayburt Üniversitesi Fen Bilimleri Dergisi 5:1, pages 19-25.
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Jaqueline E. Queiroz, Lucas D. Dias, Giuliana M. Vila Verde, Gilberto L.B. Aquino & Ademir J. Camargo. (2022) An Update on the Synthesis and Pharmacological Properties of Pyrazoles Obtained from Chalcone. Current Organic Chemistry 26:2, pages 81-90.
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Vivek Srivastava, Kirti Srivastava, Puspendra Singh & Vinay Dwivedi. (2022) Fatty acid synthase (FAS) machinery in the apicoplast: An efficient drug target for Plasmodium falciparum. Materials Today: Proceedings 68, pages 785-790.
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Vijay Kiran, Radhika Joshi & Rashmi Pundeer. (2020) α,α‐Dibromoketone precursors in the synthesis of some new thiazole derivatives: Thiazol‐2‐yl hydrazonobutanoates, thiazol‐2‐yl pyrazole‐4‐carboxylates and acids. Journal of Heterocyclic Chemistry 57:5, pages 2173-2183.
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Mousmee Sharma & Parteek Prasher. (2020) An epigrammatic status of the ‘ azole ’-based antimalarial drugs . RSC Medicinal Chemistry 11:2, pages 184-211.
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Graham L. Patrick. 2020. Antimalarial Agents. Antimalarial Agents 319 374 .
Vinay Kumar Sthalam, Ajay K. Singh & Srihari Pabbaraja. (2019) An Integrated Continuous Flow Micro-Total Ultrafast Process System (μ-TUFPS) for the Synthesis of Celecoxib and Other Cyclooxygenase Inhibitors. Organic Process Research & Development 23:9, pages 1892-1899.
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Mujahed Shaikh, Ashvini Sonone, Mazahar Farooqui & Ayesha Durrani. (2019) Trimethylsilyl Chloride Catalyzed Highly Efficient Synthesis of Schiff Bases of Thiazole in Glycerol under Microwave Irradiation. Asian Journal of Organic & Medicinal Chemistry 4:2, pages 109-112.
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Drista Sharma, Rani Soni, Praveen Rai, Bhaskar Sharma & Tarun Kumar Bhatt. (2018) Relict plastidic metabolic process as a potential therapeutic target. Drug Discovery Today 23:1, pages 134-140.
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Mohamed S. A. El-Gaby, Mustafa M. Ghorab, Zainb H. Ismail, Soad. M. Abdel-Gawad & Hala. M. Aly. (2017) Synthesis, structural characterization and anticancer evaluation of pyrazole derivatives. Medicinal Chemistry Research 27:1, pages 72-79.
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Melanie J. Shears, Cyrille Y. Botté & Geoffrey I. McFadden. (2015) Fatty acid metabolism in the Plasmodium apicoplast: Drugs, doubts and knockouts. Molecular and Biochemical Parasitology 199:1-2, pages 34-50.
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Ajay Kumar, Deepika Paliwal, Deepika Saini, Aman Thakur, Shilpy Aggarwal & Dhirender Kaushik. (2014) A comprehensive review on synthetic approach for antimalarial agents. European Journal of Medicinal Chemistry 85, pages 147-178.
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Rajni Mohil, Devinder Kumar & Satbir Mor. (2014) Synthesis and Antimicrobial Activity of Some 1,3-Disubstituted Indeno[1,2- c ]pyrazoles . Journal of Heterocyclic Chemistry 51:1, pages 203-211.
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Satbir Mor, Rajni Mohil, Devinder Kumar & Munish Ahuja. (2011) Synthesis and antimicrobial activities of some isoxazolyl thiazolyl pyrazoles. Medicinal Chemistry Research 21:11, pages 3541-3548.
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Tanushree Banerjee, Shailendra Kumar Sharma, Neha Kapoor, Vishnu Dwivedi, Namita Surolia & Avadhesha Surolia. (2011) Benzothiophene carboxamide derivatives as inhibitors of Plasmodium falciparum enoyl‐ACP reductase . IUBMB Life 63:12, pages 1101-1110.
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Gyanendra Kumar, Tanushree Banerjee, Neha Kapoor, Namita Surolia & Avadhesha Surolia. (2010) SAR and pharmacophore models for the rhodanine inhibitors of Plasmodium falciparum enoyl‐acyl carrier protein reductase . IUBMB Life 62:3, pages 204-213.
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Joel S. Freundlich, Feng Wang, Han-Chun Tsai, Mack Kuo, Hong-Ming Shieh, John W. Anderson, Louis J. Nkrumah, Juan-Carlos Valderramos, Min Yu, T.R. Santha Kumar, Stephanie G. Valderramos, William R. JacobsJrJr, Guy A. Schiehser, David P. Jacobus, David A. Fidock & James C. Sacchettini. (2007) X-ray Structural Analysis of Plasmodium falciparum Enoyl Acyl Carrier Protein Reductase as a Pathway toward the Optimization of Triclosan Antimalarial Efficacy. Journal of Biological Chemistry 282:35, pages 25436-25444.
Crossref
Gyanendra Kumar, Prasanna Parasuraman, Shailendra Kumar Sharma, Tanushree Banerjee, Krishanpal Karmodiya, Namita Surolia & Avadhesha Surolia. (2007) Discovery of a Rhodanine Class of Compounds as Inhibitors of Plasmodium falciparum Enoyl-Acyl Carrier Protein Reductase . Journal of Medicinal Chemistry 50:11, pages 2665-2675.
Crossref
Sanjay Kumar, Gyanendra Kumar, Mili Kapoor, Avadhesha Surolia & Namita Surolia. (2006) Synthesis and Evaluation of Substituted Pyrazoles: Potential Antimalarials Targeting the Enoyl‐ACP Reductase of Plasmodium falciparum.. ChemInform 37:23.
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