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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 36, 2006 - Issue 3
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Original Articles

Convenient Method for the 3‐Functionalization of Isoindazoles

Aaron Bunnell Department of Medicinal Chemistry, Roche Palo Alto LLC, Palo Alto, California, USA
,
Counde O'Yang Department of Medicinal Chemistry, Roche Palo Alto LLC, Palo Alto, California, USA
,
Andra Petrica Department of Medicinal Chemistry, Roche Palo Alto LLC, Palo Alto, California, USA
&
Michael J. Soth Department of Medicinal Chemistry, Roche Palo Alto LLC, Palo Alto, California, USACorrespondence[email protected]
Pages 285-293 | Received 28 Jul 2005, Published online: 19 Aug 2006

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Jiawei Zhang, Kaimin Kong, Xiangjun Li & Qian Zhang. (2021) Kemp-type elimination of 1-arylsulfonyl-3-iodo-1H-indazoles. Synthetic Communications 51:15, pages 2365-2376.
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Articles from other publishers (20)

Anil Kumar & Rajeev Sakhuja. 2022. Handbook of CH‐Functionalization. Handbook of CH‐Functionalization 1 38 .
Kuno Schwärzer, Saroj K. Rout, Derya Bessinger, Fabio Lima, Cara E. Brocklehurst, Konstantin Karaghiosoff, Thomas Bein & Paul Knochel. (2021) Selective functionalization of the 1 H -imidazo[1,2- b ]pyrazole scaffold. A new potential non-classical isostere of indole and a precursor of push–pull dyes . Chemical Science 12:39, pages 12993-13000.
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Huan Li, Yuxuan Han, Zi Yang, Zhenyu Yao, Lianhui Wang & Xiuling Cui. (2021) Rh(III)-catalyzed annulation of azobenzenes and α-Cl ketones toward 3-acyl-2H-indazoles. Chinese Chemical Letters 32:5, pages 1709-1712.
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Brandon A. Wright & Michael J. Ardolino. (2018) Surprising Reactivity in NiXantphos/Palladium-Catalyzed α-Arylation of Substituted Cyclopropyl Nitriles. The Journal of Organic Chemistry 84:8, pages 4670-4679.
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Meng Tang, Bingjie Chu & Xiaowei Chang. (2018) Direct N-Alkylation and Kemp Elimination Reactions of 1-Sulfonyl-1 H -Indazoles . Chemistry - An Asian Journal 13:16, pages 2109-2116.
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Arnaud ChevalierAbdelaaziz Ouahrouch, Alexandre ArnaudThibault Gallavardin & Xavier Franck. (2018) An optimized procedure for direct access to 1 H -indazole-3-carboxaldehyde derivatives by nitrosation of indoles . RSC Advances 8:24, pages 13121-13128.
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Jacob M. Ganley & Charles S. Yeung. (2017) Unprotected Indazoles Are Resilient to Ring-Opening Isomerization: A Case Study on Catalytic C–S Couplings in the Presence of Strong Base. The Journal of Organic Chemistry 82:24, pages 13557-13562.
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Zhen Long, Zhigang Wang, Danni Zhou, Danyang Wan & Jingsong You. (2017) Rh(III)-Catalyzed Regio- and Chemoselective [4 + 1]-Annulation of Azoxy Compounds with Diazoesters for the Synthesis of 2 H -Indazoles: Roles of the Azoxy Oxygen Atom . Organic Letters 19:11, pages 2777-2780.
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Arumugavel Murugan, Shinde Vidyacharan, Ruma Ghosh & Duddu S. Sharada. (2017) Metal-Free Regioselective Dual C-H Functionalization in a Cascade Fashion: Access to Isocryptolepine Alkaloid Analogues. ChemistrySelect 2:12, pages 3511-3515.
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Bao Vy Lam, Yohann Berhault, Silvia Stiebing, Christine Fossey, Thomas Cailly, Valérie Collot & Frédéric Fabis. (2016) Iodoindazoles with Selective Magnesiation at Position 3: A Route to Highly Functionalized Indazoles. Chemistry - A European Journal 22:13, pages 4440-4446.
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Taejoo Jeong, Sang Hoon Han, Sangil Han, Satyasheel Sharma, Jihye Park, Jong Suk Lee, Jong Hwan Kwak, Young Hoon Jung & In Su Kim. (2016) Access to 3-Acyl-(2 H )-indazoles via Rh(III)-Catalyzed C–H Addition and Cyclization of Azobenzenes with α-Keto Aldehydes . Organic Letters 18:2, pages 232-235.
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Yan Fang, Chengming Wang, Shengqin Su, Haizhu Yu & Yong Huang. (2014) Selective synthesis of indazoles and indoles via triazene–alkyne cyclization switched by different metals. Org. Biomol. Chem. 12:7, pages 1061-1071.
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Keika Hattori, Kazuya Yamaguchi, Junichiro Yamaguchi & Kenichiro Itami. (2012) Pd- and Cu-catalyzed C–H arylation of indazoles. Tetrahedron 68:37, pages 7605-7612.
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Adrian L. Smith, Noel D. D’Angelo, Yunxin Y. Bo, Shon K. Booker, Victor J. Cee, Brad Herberich, Fang-Tsao Hong, Claire L. M. Jackson, Brian A. Lanman, Longbin Liu, Nobuko Nishimura, Liping H. Pettus, Anthony B. Reed, Seifu Tadesse, Nuria A. Tamayo, Ryan P. Wurz, Kevin Yang, Kristin L. Andrews, Douglas A. Whittington, John D. McCarter, Tisha San Miguel, Leeanne Zalameda, Jian Jiang, Raju Subramanian, Erin L. Mullady, Sean Caenepeel, Daniel J. Freeman, Ling Wang, Nancy Zhang, Tian Wu, Paul E. Hughes & Mark H. Norman. (2012) Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases. Journal of Medicinal Chemistry 55:11, pages 5188-5219.
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Andreas Unsinn & Paul Knochel. (2012) Regioselective zincation of indazoles using TMP2Zn and Negishi cross-coupling with aryl and heteroaryl iodides. Chemical Communications 48:21, pages 2680.
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Victoria L. Blair, David C. Blakemore, Duncan Hay, Eva Hevia & David C. Pryde. (2011) Alkali-metal mediated zincation of N-heterocyclic substrates using the lithium zincate complex, (THF)Li(TMP)Zn(tBu)2 and applications in in situ cross coupling reactions. Tetrahedron Letters 52:36, pages 4590-4594.
Crossref
Zerong Wang. 2010. Comprehensive Organic Name Reactions and Reagents. Comprehensive Organic Name Reactions and Reagents.
Andreas Schmidt, Ariane Beutler & Bohdan Snovydovych. (2008) Recent Advances in the Chemistry of Indazoles. European Journal of Organic Chemistry 2008:24, pages 4073-4095.
Crossref
Larry Yet. 2008. A critical review of the 2006 literature preceded by two chapters on current heterocyclic topics. A critical review of the 2006 literature preceded by two chapters on current heterocyclic topics 208 241 .
Aaron Bunnell, Counde O'Yang, Andra Petrica & Michael J. Soth. (2006) Convenient Method for the 3‐Functionalization of Isoindazoles.. ChemInform 37:23.
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