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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 37, 2007 - Issue 19
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Original Articles

Improved Synthesis of Gefitinib and Erlotinib Hydrochloride‐ Anticancer Agents

Venkateshappa Chandregowda Vittal Mallya Scientific Research Foundation, Bangalore, India
,
Gudapati Venkateswara Rao Vittal Mallya Scientific Research Foundation, Bangalore, India
&
Goukanapalli Chandrasekara Reddy Vittal Mallya Scientific Research Foundation, Bangalore, IndiaCorrespondence[email protected]
Pages 3409-3415 | Received 05 Feb 2007, Published online: 05 Oct 2007

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Sung Kwon Kang, Seung Wook Lee, Daekoo Woo, Jaehoon Sim & Young-Ger Suh. (2017) Practical and efficient synthesis of gefitinib through selective O-alkylation: A novel concept for a transient protection group. Synthetic Communications 47:21, pages 1990-1998.
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Chandrashekara Karunakara, Udupi Aparna & Chandrasekara G. Reddy. (2015) Separation and Estimation of Intermediates Formed During Synthesis of Gefitinib via 4-Methylthio-Quinazoline Route Using High Performance Liquid Chromatography. Journal of Liquid Chromatography & Related Technologies 38:7, pages 759-764.
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A.C. Karunakara, U. Aparna, Anil Kush & G. Chandrasekara Reddy. (2013) DETECTION AND ANALYSIS OF INTERMEDIATES FORMED DURING THE SYNTHESIS OF ERLOTINIB VIA QUINAZOLINE-THIONE ROUTE USING HPLC. Journal of Liquid Chromatography & Related Technologies 36:18, pages 2547-2558.
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Articles from other publishers (16)

Pengfei Xu, Lijun Zhu, Desheng Zhang, Zilong Li, Raoling Ge & Qiang Tian. (2024) Design and synthesis of fluorine aromatic scaffolds containing drugs approved by the US FDA from 2002 to 2022. Results in Chemistry 7, pages 101446.
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Weihong Zhang, Zhiming Su, Haiwang Liu, Yingjun Zhang, Weiliang Ye, Dahua Peng, Hongpeng Xie, Hongtao Peng, Zhihong Peng, Wanrong Dong & Delie An. (2022) Manufacturable Process of a Novel EGFR Inhibitor (Larotinib) for the Treatment of ESCC. Organic Process Research & Development 26:5, pages 1470-1485.
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Long-fei Mao, Zhen-Zhen Wang, Qiong Wu, Xiaojie Chen, Jian-Xue Yang, Xin Wang & Yue-Ming Li. (2022) Design, Synthesis, and Antitumor Activity of Erlotinib Derivatives. Frontiers in Pharmacology 13.
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Amit Kumar, Ankit Siwach & Prabhakar Verma. (2022) An Overview of the Synthetic Route to the Marketed Formulations of Pyrimidine: A Review. Mini-Reviews in Medicinal Chemistry 22:6, pages 884-903.
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Mohammed A. S. Abourehab, Alaa M. Alqahtani, Bahaa G. M. Youssif & Ahmed M. Gouda. (2021) Globally Approved EGFR Inhibitors: Insights into Their Syntheses, Target Kinases, Biological Activities, Receptor Interactions, and Metabolism. Molecules 26:21, pages 6677.
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Ahmed A. Abdelgalil, Hamad M. Al-Kahtani & Fahad I. Al-Jenoobi. 2020. Profiles of Drug Substances, Excipients, and Related Methodology. Profiles of Drug Substances, Excipients, and Related Methodology 93 117 .
Yuanhong Ma, Jose Cammarata & Josep Cornella. (2019) Ni-Catalyzed Reductive Liebeskind–Srogl Alkylation of Heterocycles. Journal of the American Chemical Society 141:5, pages 1918-1922.
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Daniel Moser, Yaya Duan, Feng Wang, Yuanhong Ma, Matthew J. O'Neill & Josep Cornella. (2018) Selective Functionalization of Aminoheterocycles by a Pyrylium Salt. Angewandte Chemie International Edition 57:34, pages 11035-11039.
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Daniel Moser, Yaya Duan, Feng Wang, Yuanhong Ma, Matthew J. O'Neill & Josep Cornella. (2018) Selective Functionalization of Aminoheterocycles by a Pyrylium Salt. Angewandte Chemie 130:34, pages 11201-11205.
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Ruben Vardanyan & Victor Hruby. 2016. Synthesis of Best-Seller Drugs. Synthesis of Best-Seller Drugs 495 547 .
Kai-Hao Yin, Yi-Han Hsieh, Rohidas S. Sulake, Su-Pei Wang, Jui-I. Chao & Chinpiao Chen. (2014) Optimization of gefitinib analogues with potent anticancer activity. Bioorganic & Medicinal Chemistry Letters 24:22, pages 5247-5250.
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K. A. Chandrashekara, A. Udupi & C. G. Reddy. (2013) Separation and Estimation of Process-Related Impurities of Gefitinib by Reverse-Phase High-Performance Liquid Chromatography. Journal of Chromatographic Science 52:8, pages 799-805.
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Marcus Baumann & Ian R Baxendale. (2013) An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles. Beilstein Journal of Organic Chemistry 9, pages 2265-2319.
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Hanqing Li, Mengyao Li, Zaiquan Li, Liang Li, Shanshan Bi, Chenhui Deng, Rui Chen, Tianyan Zhou & Wei Lu. (2011) New Synthetic Route of Two Active Isomeric Metabolites of Erlotinib and Their Bioactivity Studies against Several Tumor Cell Lines. Chinese Journal of Chemistry 29:8, pages 1709-1714.
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Venkateshappa Chandregowda, Gudapati Venkateswara Rao & Goukanapalli Chandrasekara Reddy. (2008) ChemInform Abstract: Improved Synthesis of Gefitinib and Erlotinib Hydrochloride — Anticancer Agents.. ChemInform 39:10.
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G.W. Rewcastle. 2008. Comprehensive Heterocyclic Chemistry III. Comprehensive Heterocyclic Chemistry III 117 272 .

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