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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 37, 2007 - Issue 19
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Original Articles

Efficient Synthesis of (1R)‐[3,5‐Bis(trifluoromethyl)phenyl] Ethanol, a Key Intermediate for Aprepitant, an NK‐1 Receptor AntagonistFootnote

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Pages 3439-3446 | Received 23 Feb 2007, Published online: 05 Oct 2007

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Quan Yuan, Li Ma, Weixi Kong, Jianqiao Liu, Shuling Zhang, Jiajing Yan, Jing Bai, Ying He, Liya Zhou, Yunting Liu & Yanjun Jiang. Enzymatic synthesis of chiral alcohols using ketoreductases. Catalysis Reviews 0:0, pages 1-40.
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Articles from other publishers (12)

Yaohui Li, Rongzhen Zhang & Yan Xu. (2021) Structure-based mechanisms: On the way to apply alcohol dehydrogenases/reductases to organic-aqueous systems. International Journal of Biological Macromolecules 168, pages 412-427.
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Hiten B. Raval & Ashutosh V. Bedekar. (2020) One-pot kinetic resolution–Mitsunobu reaction to access optically pure compounds, using silver salts in the substitution protocol. New Journal of Chemistry 44:48, pages 21238-21243.
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Jiawei Tang, Tengyun Wei, Guowei Ni, Xiang Guo, Yuanjie Wu, Fuli Zhang & Shaoxin Chen. (2018) Development of an Efficient and Cost-Effective Enzymatic Process for Production of (R)-[3,5-bis(trifluoromethyl)phenyl] Ethanol Using Carbonyl Reductase Derived from Leifsonia sp. S749. Applied Biochemistry and Biotechnology 188:1, pages 87-100.
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Bård Helge Hoff & Eirik Sundby. (2017) Is literature data useful for identifying enzyme catalysts for new substrates? A case study on reduction of 1-aryl-2-alkanoates. Bioorganic Chemistry 74, pages 260-271.
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Gao‐Wei Zheng, Yan Ni & Jian‐He Xu. 2016. Applied Biocatalysis: From Fundamental Science to Industrial Applications. Applied Biocatalysis: From Fundamental Science to Industrial Applications 219 250 .
Nilesh Jain, Ravi B. Patel & Ashutosh V. Bedekar. (2015) Modified Kagan's amide: synthesis and application as a chiral solvating agent for hydrogen-bonding based chiral discrimination in NMR. RSC Advances 5:57, pages 45943-45955.
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Jiang Wang, María Sánchez-Roselló, José Luis Aceña, Carlos del Pozo, Alexander E. Sorochinsky, Santos Fustero, Vadim A. Soloshonok & Hong Liu. (2013) Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011). Chemical Reviews 114:4, pages 2432-2506.
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Nengqiang Wang, Jin Huang, Hongdou Luo, Pu Wang & Jun Li. (2013) Purification and characterization of a new carbonyl reductase from Leifsonia xyli HS0904 involved in stereoselective reduction of 3,5-bis(trifluoromethyl) acetophenone. Journal of Molecular Catalysis B: Enzymatic 92, pages 1-6.
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Pablo Etayo & Anton Vidal-Ferran. (2013) Rhodium-catalysed asymmetric hydrogenation as a valuable synthetic tool for the preparation of chiral drugs. Chem. Soc. Rev. 42:2, pages 728-754.
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Pablo Etayo, José Luis Núñez‐Rico, Héctor Fernández‐Pérez & Anton Vidal‐Ferran. (2011) Enantioselective Access to Chiral Drugs by using Asymmetric Hydrogenation Catalyzed by Rh(POP) Complexes. Chemistry – A European Journal 17:50, pages 13978-13982.
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Pu Wang, Jin-Bo Cai, Qi Ouyang, Jun-Yao He & Hui-Zhen Su. (2011) Asymmetric biocatalytic reduction of 3,5-bis(trifluoromethyl) acetophenone to (1R)-[3,5-bis(trifluoromethyl)phenyl] ethanol using whole cells of newly isolated Leifsonia xyli HS0904. Applied Microbiology and Biotechnology 90:6, pages 1897-1904.
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Pravinchandra J. Vankawala, Naveenkumar Kolla, Chandrashekar R. Elati, M. Sreenivasulu, K. Arun Kumar, Yerrimilli Anjaneyulu, Sundaram Venkatraman, Apurba Bhattacharya & Vijayavitthal T. Mathad. (2008) ChemInform Abstract: Efficient Synthesis of (1R)‐[3,5‐Bis(trifluoromethyl)phenyl] Ethanol, a Key Intermediate for Aprepitant, an NK‐1 Receptor Antagonist.. ChemInform 39:10.
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