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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 20
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Original Articles

Efficient One-Pot Synthesis of the GABAB Positive Allosteric Modulator (R,S)-5,7-Di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one

Andre M. Alker Hoffmann-La Roche AG, Basel, Switzerland
,
François Grillet Hoffmann-La Roche AG, Basel, Switzerland
,
Pari Malherbe Hoffmann-La Roche AG, Basel, Switzerland
,
Roger D. Norcross Hoffmann-La Roche AG, Basel, Switzerland
,
Andrew W. Thomas Hoffmann-La Roche AG, Basel, Switzerland
&
Raffaello Masciadri Hoffmann-La Roche AG, Basel, SwitzerlandCorrespondence[email protected]
Pages 3398-3405 | Received 15 Jan 2008, Published online: 30 Sep 2008

Citations (9)

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Wolfgang Froestl. (2010) Novel GABAB receptor positive modulators: a patent survey. Expert Opinion on Therapeutic Patents 20:8, pages 1007-1017.
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Articles from other publishers (8)

Fabrizio Vetica, Renata Marcia de Figueiredo, Emilia Cupioli, Augusto Gambacorta, M. Antonietta Loreto, Martina Miceli & Tecla Gasperi. (2016) First asymmetric organocatalyzed domino Friedel–Crafts/lactonization reaction in the enantioselective synthesis of the GABAB receptor modulator (S)-BHFF. Tetrahedron Letters 57:7, pages 750-753.
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Claudia Mugnaini & Federico Corelli. 2016. GABAB Receptor. GABAB Receptor 33 52 .
Masaaki Yohda & Yasunori Yamamoto. (2015) Ruthenium–Me-BIPAM-catalyzed addition reaction of aryl-boronic acids to benzofuran-2,3-diones for the enantioselective synthesis of 3-aryl-3-hydroxybenzofuran-2-ones. Tetrahedron: Asymmetry 26:24, pages 1430-1435.
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Hai Ren, Pan Wang, Lijia Wang & Yong Tang. (2015) Catalytic Asymmetric Synthesis of 3-Hydroxy-3-trifluoromethyl Benzofuranones via Tandem Friedel–Crafts/Lactonization Reaction. Organic Letters 17:19, pages 4886-4889.
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Fabrizio Vetica, Alessandra Pelosi, Augusto Gambacorta, M. Antonietta Loreto, Martina Miceli & Tecla Gasperi. (2014) Catalytic Friedel-Crafts/Lactonization Domino Reaction: Facile Access to 3-Hydroxybenzofuran-2-one Scaffold. European Journal of Organic Chemistry 2014:9, pages 1899-N1906.
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Changho Han, Amy E. Salyer, Eun Hoo Kim, Xinyi Jiang, Rachel E. Jarrard, Matthew S. Powers, Aaron M. Kirchhoff, Tolani K. Salvador, Julia A. Chester, Gregory H. Hockerman & David A. Colby. (2013) Evaluation of Difluoromethyl Ketones as Agonists of the γ-Aminobutyric Acid Type B (GABA B ) Receptor . Journal of Medicinal Chemistry 56:6, pages 2456-2465.
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Wolfgang Froestl. 2010. GABABReceptor Pharmacology - A Tribute to Norman Bowery. GABABReceptor Pharmacology - A Tribute to Norman Bowery 19 62 .
Andre M. Alker, Francois Grillet, Pari Malherbe, Roger D. Norcross, Andrew W. Thomas & Raffaello Masciadri. (2009) ChemInform Abstract: Efficient One‐Pot Synthesis of GABA B Positive Allosteric Modulator (R,S)‐5,7‐Di‐tert‐butyl‐3‐hydroxy‐3‐trifluoromethyl‐3H‐benzofuran‐2‐one. . ChemInform 40:14.
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