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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2010 - Issue 8
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Original Articles

Synthesis of 2,3-Dihydroquinazoline-4(1H)-ones

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Pages 1231-1242 | Received 21 Apr 2009, Published online: 12 Mar 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Cheng-Hang Liu, Qiong Wang, Zenglai Xu, Dongling Li & Yuhong Zheng. (2022) 5,5’-Indigodisulfonic acid as an efficient catalyst for the synthesis of 2,3-dihydroquinazolinone derivatives. Synthetic Communications 52:13-14, pages 1537-1545.
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Abdolrahman Keyhani, Mohammad Nikpassand, Leila Zare Fekri & Hassan Kefayati. (2022) Green Synthesis of Novel Azo-Linked 2-Aryl-quinazolinones Using of NiFe2O4@SP@GA Nanoparticle. Polycyclic Aromatic Compounds 42:5, pages 2607-2616.
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Samir Y. Abbas, Khairy A. M. El-Bayouki & Wahid M. Basyouni. (2016) Utilization of isatoic anhydride in the syntheses of various types of quinazoline and quinazolinone derivatives. Synthetic Communications 46:12, pages 993-1035.
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Seyed Mostafa Ebrahimi, Mohammad Mahdavi, Saeed Emami, Mina Saeedi, Mehdi Asadi, Loghman Firoozpour, Mehdi Khoobi, Kouros Divsalar, Abbas Shafiee & Alireza Foroumadi. (2014) Green and Catalyst-Free One-Pot Synthesis of Anthranilamide Schiff Bases: An Approach Toward Sirtinol. Synthetic Communications 44:5, pages 665-673.
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Jitender M. Khurana & Sanjay Kumar. (2011) An efficient, catalyst free synthesis of 3-(2′'-benzothiazolyl)-2,3-dihydroquinazolin-4(1H)-ones in aqueous medium. Green Chemistry Letters and Reviews 4:4, pages 321-325.
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Articles from other publishers (74)

Saeed Rahimi, Shefa Mirani Nezhad, Ehsan Nazarzadeh Zare, Seied Ali Pourmousavi, Mohiedin Boroujerdian & Samanesadat Hosseini. (2023) Synthesis of antioxidant and antibacterial active quinazolinones by carboxymethyl cellulose@MnFe2O4 biocatalyst. Inorganic Chemistry Communications 158, pages 111556.
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Nastaran Ghanbari & Hossein Ghafuri. (2023) Pyromellitic acid grafted to cross-linked LDH by dendritic units: An efficient and recyclable heterogeneous catalyst for green synthesis of 2,3-dihydro quinazoline and dihydropyrimidinones derivatives. Heliyon 9:11, pages e20978.
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Leyla Nazemi Nasirmahale, Farhad Shirini & Omid Goli Jolodar. (2023) Poly(4-vinylpyridinum) trinitromethanide: a useful and efficient heterogeneous catalyst for the synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives under green conditions. Research on Chemical Intermediates.
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Zahra Baymaninezhad, Haman Tavakkoli, Seyyed Jafar Saghanezhad & Elham Tahanpesar. (2023) Melamine-terephthalaldehyde covalent organic framework-copper-tetrabenzenecarboxylic acid metal organic framework (COF–MOF): an efficient heterogeneous acidic catalyst for the one-pot preparation of 2,3-dihydroquinazoline-4(1H)-one derivatives. Research on Chemical Intermediates.
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Mohammad Nikpassand & Leila Zare Fekri. (2023) Ultrasound-promoted Regioselective Synthesis of 2-aryl-quinazolinones Using Citric Acid as a Natural and Efficient Media and Catalyst. Letters in Organic Chemistry 20:8, pages 763-769.
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Akshay Pandurang Gurav, Rutikesh Pandit Gurav, Rutuja Ramesh Zond, Nayak Devappa Satyanarayan, Nippu Ningegowda Belur & Shankar Poshatti Hangirgekar. (2023) Design and synthesis of γ‐Fe 2 O 3 @Ag‐S‐CH 2 ‐COOH nanocatalyst for one‐pot synthesis of 2,3‐dihydroquinazolin‐4(1 H )‐ones and their anti‐skin cancer activity . Applied Organometallic Chemistry 37:6.
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Subrata Sahoo & Shantanu Pal. (2023) Access to Dihydroquinazolinones, spiro‐Quinazolinones and their Bioactive Molecular Scaffolds by Exploring the Unique Reactivity of 2‐Nitrobenzonitrile towards Cu‐Hydrazine Hydrate. ChemistrySelect 8:8.
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Ehsan Valiey, Mohammad G. Dekamin & Shirin Bondarian. (2023) Sulfamic acid grafted to cross-linked chitosan by dendritic units: a bio-based, highly efficient and heterogeneous organocatalyst for green synthesis of 2,3-dihydroquinazoline derivatives. RSC Advances 13:1, pages 320-334.
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Abdolrahman Keyhani, Mohammad Nikpassand, Leila Zare Fekri & Hassan Kefayati. (2021) Green Synthesis of Novel Azo-Linked 2-Aryl-Quinazolinones Using Fe3O4@SP@TA Nanoparticle. Journal of Cluster Science 33:4, pages 1589-1599.
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M. Nikpassand, L. Zare Fekri & F. Safa. (2022) Novel Route for the Synthesis of 2-Arylquinazolinones Using Magnetic Nanocomposite of Multiwalled Carbon Nanotube. Russian Journal of Organic Chemistry 58:4, pages 564-571.
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V.M. Desai, A.T. Birajdar, S.P. Patil, R.V. Kupwade, M.B. Deshmukh & S.S. Patil. (2022) An Expedient Synthesis of 2-Aryl-substituted 2,3-Dihydroquinazolin-4(1H)-ones in Low Transition Temperature Mixture (LTTM) containing SnCl2 and L-Proline. Asian Journal of Chemistry 34:7, pages 1886-1892.
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Tridev Ghosh, Indradip Mandal, Soumya Jyoti Basak & Jyotirmayee Dash. (2021) Potassium tert -Butoxide Promoted Synthesis of Dihydroquinazolinones . The Journal of Organic Chemistry 86:21, pages 14695-14704.
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Yousef Mardani, Zahed Karimi-Jaberi & Mohammad Jaafar Soltanian Fard. (2021) One-pot synthesis of 1-(benzothiazolylamino)aryl methyl-2-naphthols and 3-benzothiazolyl 2,3-dihydroquinazolinones using a magnetically recoverable core–shell nanocomposite as catalyst. Zeitschrift für Naturforschung B 76:6-7, pages 385-393.
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Shah Imtiaz, Jahangir Ahmad war, Syqa Banoo & Sarfaraz khan. (2021) α-Aminoazoles/azines: key reaction partners for multicomponent reactions. RSC Advances 11:19, pages 11083-11165.
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Aratrika Chakraborty, Tania Chowdhury, María Isabel Menéndez & Tanmay Chattopadhyay. (2020) Iron Complexes Anchored onto Magnetically Separable Graphene Oxide Sheets: An Excellent Catalyst for the Synthesis of Dihydroquinazoline-Based Compounds. ACS Applied Materials & Interfaces 12:34, pages 38530-38545.
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Mohammad Reza Anizadeh, Mohammad Ali Zolfigol, Meysam Yarie, Morteza Torabi & Saeid Azizian. (2020) Synthesis, characterization and catalytic application of tributyl(carboxymethyl)phosphonium bromotrichloroferrate as a new magnetic ionic liquid for the preparation of 2,3-dihydroquinazolin-4(1H)-ones and 4H-pyrimidobenzothiazoles. Research on Chemical Intermediates 46:8, pages 3945-3960.
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Yang Yang, Renzhong Fu, Yang Liu, Jing Cai & Xiaojun Zeng. (2020) Microwave-promoted one-pot three-component synthesis of 2,3-dihydroquinazolin-4(1H)-ones catalyzed by heteropolyanion-based ionic liquids under solvent-free conditions. Tetrahedron 76:27, pages 131312.
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Sara Oudi, Ali Reza Oveisi, Saba Daliran, Mostafa Khajeh & Elias Teymoori. (2020) Brønsted-Lewis dual acid sites in a chromium-based metal-organic framework for cooperative catalysis: Highly efficient synthesis of quinazolin-(4H)-1-one derivatives. Journal of Colloid and Interface Science 561, pages 782-792.
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Mohammad Anwar Erfan, Batool Akhlaghinia & Sara S. E. Ghodsinia. (2020) An Efficient Green Protocol for Synthesis of 2,3‐Dihydroquinazolin‐4(1 H )‐ones Using SBA‐16/GPTMS‐TSC‐Cu I under Solvent‐Free Conditions . ChemistrySelect 5:7, pages 2306-2316.
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Javad Safaei-Ghomi, Raheleh Teymuri & Atefeh Bakhtiari. (2019) Co-aminobenzamid@Al-SBA-15: a favorable catalyst in synthesis of 2,3-dihydroquinazolin-4(1H)-ones. BMC Chemistry 13:1.
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Alireza Barmak, Khodabakhsh Niknam & Gholamhossein Mohebbi. (2019) Synthesis, Structural Studies, and α-Glucosidase Inhibitory, Antidiabetic, and Antioxidant Activities of 2,3-Dihydroquinazolin-4(1 H )-ones Derived from Pyrazol-4-carbaldehyde and Anilines . ACS Omega 4:19, pages 18087-18099.
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Javad Safaei‐Ghomi & Raheleh Teymuri. (2019) A three‐component process for the synthesis of 2,3‐dihydroquinazolin‐4(1 H )‐one derivatives using nanosized nickel aluminate spinel crystals as highly efficient catalysts . Journal of the Chinese Chemical Society 66:11, pages 1490-1498.
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Akram Fakhri, Ali Naghipour & Zahra Haji Ghasemi. (2018) Catalytic performance of tannic acid-SO3H supported on Fe3O4@SiO2 nanoparticles for synthesis of 2,3-dihydroquinazolin-4(1H)-ones. Solid State Sciences 83, pages 107-114.
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Hamid Reza Safaei, Mohsen Shekouhy & Somayeh Ghorbanzadeh. (2018) Polyethylene Glycol‐Bonded Tetraethyl Ammonium Hydroxide ([PEG‐TEA]OH): A New Surfactant‐Combined Base Catalyst for the Synthesis of 2,3‐Dihydroquinazolin‐4(1 H )‐ones in Water . ChemistrySelect 3:17, pages 4750-4759.
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Mariateresa Badolato, Francesca Aiello & Nouri Neamati. (2018) 2,3-Dihydroquinazolin-4(1 H )-one as a privileged scaffold in drug design . RSC Advances 8:37, pages 20894-20921.
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Chetan K. Khatri, Manisha S. Patil & Ganesh U. Chaturbhuj. (2017) Sulfated polyborate: mild, efficient and eco-friendly catalyst for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones. Journal of the Iranian Chemical Society 14:8, pages 1683-1689.
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Seied Ali Pourmousavi, Ayoob Kanaani, Hamid Reza Fatahi, Fatemeh Ghorbani & Davood Ajloo. (2017) SbCl 3 as effective catalyst for the preparation of 2,3-Dihydroquinazolin-4(1 H )-ones, spectroscopic investigation and DFT study. Journal of Physics and Chemistry of Solids 106, pages 82-93.
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Mohsen Esmaeilpour, Jaber Javidi, Saeed Zahmatkesh & Nafiseh Fahimi. (2016) One-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones by Fe3O4@SiO2-imid-PMAn nano-catalyst under ultrasonic irradiation and reflux conditions. Monatshefte für Chemie - Chemical Monthly 148:5, pages 947-956.
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Ramin Ghorbani-Vaghei, Azadeh Shahriari, Yaser Maghbooli & Jafar Mahmoudi. (2016) Efficient synthesis of novel quinazoline-4(1H)-one derivatives by N-halosulfonamides. Research on Chemical Intermediates 43:2, pages 983-993.
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K. Kumar G. Ramakrishna, Ravi Kumar Thakur, Venkata Reddy Pasam, Jyotsana Pandey, Rohit Mahar, Sanjeev K. Shukla, Akhilesh K. Tamrakar & Rama Pati Tripathi. (2017) Synthesis of novel glycosyl-1,2,3-1H-triazolyl methyl quinazolin-4(3H)-ones and their effect on GLUT4 translocation. Tetrahedron 73:2, pages 187-203.
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Javad Safari & Soheila Gandomi-Ravandi. (2017) The combined role of heterogeneous catalysis and ultrasonic waves on the facile synthesis of 2,3-dihydroquinazolin-4(1H)-ones. Journal of Saudi Chemical Society 21, pages S415-S424.
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Jin Zhang, Pei Cheng, Yangmin Ma, Jia Liu, Zhi Miao, Decheng Ren, Chao Fan, Ming Liang & Le Liu. (2016) An efficient nano CuO-catalyzed synthesis and biological evaluation of quinazolinone Schiff base derivatives and bis-2,3-dihydroquinazolin-4(1H)-ones as potent antibacterial agents against Streptococcus lactis. Tetrahedron Letters 57:47, pages 5271-5277.
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Suman Kr Ghosh & Rajagopal Nagarajan. (2016) Deep eutectic solvent mediated synthesis of quinazolinones and dihydroquinazolinones: synthesis of natural products and drugs. RSC Advances 6:33, pages 27378-27387.
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Ali Reza Oveisi, Ahmad Khorramabadi-zad & Saba Daliran. (2016) Iron-based metal–organic framework, Fe(BTC): an effective dual-functional catalyst for oxidative cyclization of bisnaphthols and tandem synthesis of quinazolin-4(3H)-ones. RSC Advances 6:2, pages 1136-1142.
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Nasrin Razavi & Batool Akhlaghinia. (2016) Hydroxyapatite nanoparticles (HAP NPs): a green and efficient heterogeneous catalyst for three-component one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives in aqueous media. New Journal of Chemistry 40:1, pages 447-457.
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Seyedeh Bahareh Azimi & Javad Azizian. (2016) Reaction of benzyl alcohols, isatoic anhydride, and primary amines mediated by I 2 /K 2 CO 3 in water: a new and green approach for the synthesis of 2,3-dihydroquinazolin-4(1 H )-ones. Tetrahedron Letters 57:2, pages 181-184.
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Ashraf Moradi, Reza Heydari & Malek Taher Maghsoodlou. (2014) Agar: a novel, efficient, and biodegradable catalyst for the one-pot three-component and green synthesis of 2,3-dihydroquinazolin-4(1H)-one, 4H-pyrimidobenzothiazole and 2-aminobenzothiazolomethylnaphthol derivatives. Research on Chemical Intermediates 41:10, pages 7377-7391.
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Abolfazl Olyaei, Fatemeh Rahbarian & Mahdieh Sadeghpour. (2015) Green and Catalyst-free One-pot Synthesis Of 2,3-dihydroquinazolin-4(1h)-ones in Water. Chemistry of Heterocyclic Compounds 51:10, pages 899-902.
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Ali R. Oveisi, Kainan Zhang, Ahmad Khorramabadi-zad, Omar K. Farha & Joseph T. Hupp. (2015) Stable and catalytically active iron porphyrin-based porous organic polymer: Activity as both a redox and Lewis acid catalyst. Scientific Reports 5:1.
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Bao-Hua Chen, Ji-Tai Li & Guo-Feng Chen. (2015) Efficient synthesis of 2,3-disubstituted-2,3-dihydroquinazolin-4(1H)-ones catalyzed by dodecylbenzenesulfonic acid in aqueous media under ultrasound irradiation. Ultrasonics Sonochemistry 23, pages 59-65.
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Ritu Dixit, Hemal Mehta & Bharat Dixit. (2014) Synthesis, characterization and antimicrobial studies of new 2-(2-chloroquinolin-3-yl)-3-(substituted phenyl/pyridinyl)quinazolin-4(3H)-one derivatives using l-proline as a catalyst. Medicinal Chemistry Research 24:2, pages 773-786.
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S. Nagarajan, Tanveer Mahamadali Shaikh & Elango Kandasamy. (2015) An ionic liquid catalyzed reusable protocol for one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-one under mild conditions. New Journal of Chemistry 39:12, pages 9693-9699.
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Foad Shaghayeghi Toosi & Mohsen Khakzadi. (2013) A new and facile synthesis 2,3-dihydroquinazolin-4(1H)-ones. Research on Chemical Intermediates 41:1, pages 311-317.
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Arash Ghorbani-Choghamarani & Masoomeh Norouzi.. (2014) Synthesis of copper (II)-supported magnetic nanoparticle and study of its catalytic activity for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones. Journal of Molecular Catalysis A: Chemical 395, pages 172-179.
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Hamid Reza Shaterian, Nafiseh Fahimi & Kobra Azizi. (2013) New applications of phosphoric acid supported on alumina (H3PO4–Al2O3) as a reusable heterogeneous catalyst for preparation of 2,3-dihydroquinazoline-4(1H)-ones, 2H-indazolo[2,1-b]phthalazinetriones, and benzo[4,5]imidazo[1,2-a]pyrimidines. Research on Chemical Intermediates 40:5, pages 1879-1898.
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Jian Wu, Xianli Du, Juan Ma, Yuping Zhang, Qingcai Shi, Lijun Luo, Baoan Song, Song Yang & Deyu Hu. (2014) Preparation of 2,3-dihydroquinazolin-4(1H)-one derivatives in aqueous media with β-cyclodextrin-SO 3 H as a recyclable catalyst . Green Chem. 16:6, pages 3210-3217.
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Parthasaradhi Yerram, Rakhi Chowrasia, Suresh Seeka & Savitha Jyostna Tangenda. (2013) Polyethylene glycol (PEG-400) as a medium for novel and efficient synthesis of 2-phenyl-2,3-dihydroquinazolin-4(1H)-one derivatives. European Journal of Chemistry 4:4, pages 462-466.
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Javad Safari & Soheila Gandomi-Ravandi. (2013) Microwave-accelerated three components cyclocondensation in the synthesis of 2,3-dihydroquinazolin-4(1H)-ones promoted by Cu-CNTs. Journal of Molecular Catalysis A: Chemical 371, pages 135-140.
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Hyacintha Rennet Lobo, Balvant Shyam Singh & Ganapati Subray Shankarling. (2012) Bio-compatible eutectic mixture for multi-component synthesis: A valuable acidic catalyst for synthesis of novel 2,3-dihydroquinazolin-4(1H)-one derivatives. Catalysis Communications 27, pages 179-183.
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M. Wang, T. T. Zhang, J. J. Gao & Y. Liang. (2012) Cation-exchange resin as an efficient hetero-geneous catalyst for one-pot three-component synthesis of 2,3-dihydro-4(1H)-quinazolinones. Chemistry of Heterocyclic Compounds 48:6, pages 897-902.
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Zahed Karimi-Jaberi & Leila Zarei. (2012) Tris(Hydrogensulfato)Boron Catalysed Rapid Synthesis of 2-Substituted-2,3-Dihydroquinazolin-4(1 H )-Ones under Solvent-Free Conditions . Journal of Chemical Research 36:4, pages 194-196.
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Min Wang, Ting Ting Zhang, Yan Liang & Jing Jing Gao. (2011) Strontium chloride-catalyzed one-pot synthesis of 2, 3-dihydroquinazolin-4(1H)-ones in protic media. Chinese Chemical Letters 22:12, pages 1423-1426.
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Richard A. Bunce & Baskar Nammalwar. (2011) New conditions for synthesis of (±)-2-monosubstituted and (±)-2,2-disubstituted 2,3-dihydro-4(1H)-quinazolinones from 2-nitro- and 2-aminobenzamide. Journal of Heterocyclic Chemistry 48:5, pages 991-997.
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Ghashang Majid, Azizi Kobra, Moulavi‐Pordanjani Hamed & Shaterian Hamid Reza. (2011) Eco‐friendly and Efficient Synthesis of 2,3‐Dihydroquinazolin‐4(1 H )‐ones . Chinese Journal of Chemistry 29:8, pages 1617-1623.
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Zahed Karimi-Jaberi & Reza Arjmandi. (2011) Acetic acid-promoted, efficient, one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones. Monatshefte für Chemie - Chemical Monthly 142:6, pages 631-635.
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Zhan-Hui Zhang, Hong-Yan Lü, Shu-Hong Yang & Jian-Wu Gao. (2010) Synthesis of 2,3-Dihydroquinazolin-4(1 H )-ones by Three-Component Coupling of Isatoic Anhydride, Amines, and Aldehydes Catalyzed by Magnetic Fe 3 O 4 Nanoparticles in Water . Journal of Combinatorial Chemistry 12:5, pages 643-646.
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