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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 41, 2011 - Issue 19
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Original Articles

Convenient and Efficient Synthesis of Some Novel Fused Thieno Pyrimidines Using Gewald's Reaction

Ramakrishna V. S. Nirogi Discovery Research, Medicinal Chemistry, Suven Life Sciences Ltd., Hyderabad, Andhra Pradesh, IndiaCorrespondence[email protected]
,
Rama Sastri Kambhampati Discovery Research, Medicinal Chemistry, Suven Life Sciences Ltd., Hyderabad, Andhra Pradesh, India
,
Prabhakar Kothmirkar Discovery Research, Medicinal Chemistry, Suven Life Sciences Ltd., Hyderabad, Andhra Pradesh, India
,
Sobhanadri Arepalli Discovery Research, Medicinal Chemistry, Suven Life Sciences Ltd., Hyderabad, Andhra Pradesh, India
,
Narasimha Reddy G. Pamuleti Discovery Research, Medicinal Chemistry, Suven Life Sciences Ltd., Hyderabad, Andhra Pradesh, India
,
Anil K. Shinde Discovery Research, Medicinal Chemistry, Suven Life Sciences Ltd., Hyderabad, Andhra Pradesh, India
&
P. K. Dubey Department of Chemistry, Jawaharlal Nehru Technological University, Hyderabad, Andhra Pradesh, India
 show all
Pages 2835-2851 | Received 01 May 2010, Published online: 29 Jun 2011

Citations (15)

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Marwa Sharaky, Marwa Kamel, Marwa A. Aziz, Mervat Omran, Monira M. Rageh, Khaled A. M. Abouzid & Samia A. Shouman. (2020) Design, synthesis and biological evaluation of a new thieno[2,3-d]pyrimidine-based urea derivative with potential antitumor activity against tamoxifen sensitive and resistant breast cancer cell lines. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1641-1656.
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Articles from other publishers (14)

Samah Higazy, Nermin Samir, Ahmed El-Khouly, Simone Giovannuzzi, Paloma Begines, Hatem M. Gaber, Claudiu T. Supuran & Khaled A.M. Abouzid. (2024) Identification of thienopyrimidine derivatives tethered with sulfonamide and other moieties as carbonic anhydrase inhibitors: Design, synthesis and anti-proliferative activity. Bioorganic Chemistry 144, pages 107089.
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Joseph S. Saleh, Soha R. Abd El Hadi, Hany S. Ibrahim, Eman Z. Elrazaz & Khaled A. M. Abouzid. (2023) Fragment merging approach for design, synthesis, and biological assessment of urea/acetyl hydrazide clubbed thienopyrimidine derivatives as GSK-3β inhibitors. BMC Chemistry 17:1.
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Ahmed S. Abdelkhalek, Hend Kothayer, Samar Rezq, Khaled Y. Orabi, Damian G. Romero & Osama I. El-Sabbagh. (2023) Synthesis of new multitarget-directed ligands containing thienopyrimidine nucleus for inhibition of 15-lipoxygenase, cyclooxygenases, and pro-inflammatory cytokines. European Journal of Medicinal Chemistry 256, pages 115443.
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Menna Tallah M. Sayed, Rasha A. Hassan, Peter A. Halim & Afaf K. El-Ansary. (2023) Recent updates on thienopyrimidine derivatives as anticancer agents. Medicinal Chemistry Research 32:4, pages 659-681.
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A. A. Fayed, Y. M. Alahmadi, M. N. M. Yousif, N. M. Yousif, A. A. Amer, A. F. El-Farargy, N. H. Ouf & F. A. Gad. (2019) Synthesis and Anti-Inflammatory Activity of Some New Pyrimidinothienocinnoline Derivatives. Russian Journal of General Chemistry 89:9, pages 1887-1895.
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Tim J. FyfeBarbara Zarzycka, Herman D. Lim, Barrie Kellam, Shailesh N. Mistry, Vsevolod Katrich, Peter J. Scammells, J. Robert Lane & Ben Capuano. (2018) A Thieno[2,3- d ]pyrimidine Scaffold Is a Novel Negative Allosteric Modulator of the Dopamine D 2 Receptor . Journal of Medicinal Chemistry 62:1, pages 174-206.
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Laxmikant S. Pavase & Dhananjay V. Mane. (2016) Synthesis and anticancer activities of novel (tetrahydrobenzo [4,5] thieno [2,3-d] pyrimidine-4-yl)-pyrolidine-2-carboxylic acid derivatives. Medicinal Chemistry Research 25:10, pages 2380-2391.
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Marwa A. Aziz, Rabah A. T. Serya, Deena S. Lasheen, Amal Kamal Abdel-Aziz, Ahmed Esmat, Ahmed M. Mansour, Abdel Nasser B. Singab & Khaled A. M. Abouzid. (2016) Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents. Scientific Reports 6:1.
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Pingping Liu, Chen Shu, Lujie Liu, Qingchun Huang & Yanqing Peng. (2016) Design and synthesis of thiourea derivatives with sulfur-containing heterocyclic scaffolds as potential tyrosinase inhibitors. Bioorganic & Medicinal Chemistry 24:8, pages 1866-1871.
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Ram W. Sabnis. (2016) The Gewald reaction in dye chemistry. Coloration Technology 132:1, pages 49-82.
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A.A. Gryshchenko, V.G. Bdzhola, A.O. Balanda, N.V. Briukhovetska, I.M. Kotey, A.G. Golub, T.P. Ruban, L.L. Lukash & S.M. Yarmoluk. (2015) Design, synthesis and biological evaluation of N-phenylthieno[2,3-d]pyrimidin-4-amines as inhibitors of FGFR1. Bioorganic & Medicinal Chemistry 23:9, pages 2287-2293.
Crossref
Saleh Bahashwan, Ahmed Fayed, Abd Amr, Eman Flefel & Atef Kalmouch. (2013) Synthesis and Pharmacological Activities of Some New Triazolo- and Tetrazolopyrimidine Derivatives. Molecules 18:12, pages 15051-15063.
Crossref
Naif O. Al-Harbi, Saleh A. Bahashwan, Ahmed A. Fayed, Moutasem S. Aboonq & Abd El-Galil E. Amr. (2013) Anti-parkinsonism, hypoglycemic and anti-microbial activities of new poly fused ring heterocyclic candidates. International Journal of Biological Macromolecules 57, pages 165-173.
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Ramakrishna V. S. Nirogi, Rama Sastri Kambhampati, Prabhakar Kothmirkar, Sobhanadri Arepalli, Narasimha Reddy G. Pamuleti, Anil K. Shide & P. K. Dubey. (2012) ChemInform Abstract: Convenient and Efficient Synthesis of Some Novel Fused Thieno Pyrimidines Using Gewald′s Reaction.. ChemInform 43:11.
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