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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 42, 2012 - Issue 6
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Original Articles

Regioselective Synthesis of 1,3,5-Trisubstituted Pyrazoles

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Pages 836-842 | Received 05 Sep 2010, Published online: 11 Nov 2011

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Behrooz Maleki, Fatemeh Barakchi Tabrizy, Reza Tayebee & Mehdi Baghayeri. (2019) Oxidative Aromatization of 1,3,5-trisubstituted 2-pyrazolines Using Oxalic Acid/Sodium Nitrite System. Polycyclic Aromatic Compounds 39:2, pages 93-98.
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Articles from other publishers (29)

Dipak J. Dahatonde, Aritra Ghosh, Adilakshmi Vutla & Sanjay Batra. (2023) Iodine‐Mediated One‐Pot Synthesis of 1,4,5‐Substituted Pyrazoles from MBH Acetates via Allyl Hydrazone Intermediate. European Journal of Organic Chemistry 26:28.
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Tamilthendral Veerappan & Ramesh Rengan. (2023) Arene Binuclear Ru(II)-Promoted Sustainable Synthesis of Substituted Pyrazoles from Alcohols via Acceptorless Dehydrogenative Annulation. Organic Letters 25:22, pages 4162-4167.
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Anjali Gupta, Sinthiya Gawandi, Vandna, Inderjeet Yadav, Hari Mohan, Vidya G Desai & Sachin Kumar. (2023) Analysis of fluoro based pyrazole analogues as a potential therapeutics candidate against Japanese encephalitis virus infection. Virus Research 323, pages 198955.
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Mohit K. Tiwari, Ashif Iqubal & Parthasarathi Das. (2022) Intramolecular oxidative C–N bond formation under metal-free conditions: One-pot global functionalization of pyrazole ring. Tetrahedron 126, pages 133059.
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Lian-Mei Chen, Chuang Zhou, Jing Li, Jun Li, Xiao-Qiang Guo & Tai-Ran Kang. (2022) Copper-catalyzed reactions of α,β-unsaturated N -tosylhydrazones with diaryliodonium salts to construct N -arylpyrazoles and diaryl sulfones . Organic & Biomolecular Chemistry 20:35, pages 7011-7016.
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Chrisna Matthee, Gisella Terre’Blanche, Lesetja J. Legoabe & Helena D. Janse van Rensburg. (2021) Exploration of chalcones and related heterocycle compounds as ligands of adenosine receptors: therapeutics development. Molecular Diversity 26:3, pages 1779-1821.
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Larry Yet. 2022. Comprehensive Heterocyclic Chemistry IV. Comprehensive Heterocyclic Chemistry IV 1 112 .
Sainath Zangade & Pravinkumar Patil. (2020) A Review on Solvent-free Methods in Organic Synthesis. Current Organic Chemistry 23:21, pages 2295-2318.
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Sulaksha Desai, Vidya Desai & Sunil Shingade. (2020) In-vitro Anti-cancer assay and apoptotic cell pathway of newly synthesized benzoxazole-N-heterocyclic hybrids as potent tyrosine kinase inhibitors. Bioorganic Chemistry 94, pages 103382.
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Yohei Minami, Akihito Konishi & Makoto Yasuda. (2019) Synthesis of α-Alkenyl α,β-Unsaturated Ketones via Dehydrogermylation of Oxagermacycles with Regeneration of the Germanium(II) Species. Organic Letters 21:24, pages 9818-9823.
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Lian-Mei Chen, Juan Zhao, An-Jie Xia, Xiao-Qiang Guo, Ya Gan, Chuang Zhou, Zai-Jun Yang, Jun Yang & Tai-Ran Kang. (2019) A base-promoted cascade reaction of α,β-unsaturated N -tosylhydrazones with o -hydroxybenzyl alcohols: highly regioselective synthesis of N-sec -alkylpyrazoles . Organic & Biomolecular Chemistry 17:37, pages 8561-8570.
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Rimpy Bhatia, Kulbir Kadyan, Meenakshi Duhan, Meena Devi, Rahul Singh, Ramesh C. Kamboj & Parvin Kumar. (2019) A Serendipitous Synthesis: SiO 2 ‐HNO 3 Mediated Oxidative Aromatization and Regioselective Nitration of 1,3,5‐Trisubstituted‐4,5‐Dihydro‐1 H ‐Pyrazoles . ChemistrySelect 4:35, pages 10417-10424.
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Lin Zeng, Xiao-Qiang Guo, Zai-Jun Yang, Ya Gan, Lian-Mei Chen & Tai-Ran Kang. (2019) Metal-free and highly regioselective synthesis of N-heteroaryl substituted pyrazoles from α,β-unsaturated N-tosylhydrazones and heteroaryl chlorides. Tetrahedron Letters 60:33, pages 150943.
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Sinthiya J. Gawandi, Vidya G. Desai & Sunil G. Shingade. (2019) Design, synthesis, and biological evaluation of 1,3,5-trisubstituted pyrazoles as tyrosine kinase inhibitors. Medicinal Chemistry Research 28:3, pages 267-278.
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Li Tang, Minyan Ma, Qi Zhang, Huan Luo, Tao Wang & Yonghai Chai. (2017) Metal-Free Synthesis of Pyrazoles from 1,3-Diarylpropenes and Hydrazines via Multiple Inter-/Intramolecular C-H Aminations . Advanced Synthesis & Catalysis 359:15, pages 2610-2620.
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Amy N. Hockstedler, Beatrice A. Edjah, Saajid Z. Azhar, Hadrian Mendoza, Nicole A. Brown, Hayley B. Arrowood, Andrew C. Clay, Anand B. Shah, Glenda M. Duffek, Jianmei Cui & Alfons L. Baumstark. (2017) 13 C NMR spectroscopy of heterocycles: 1-phenyl-3-aryl/ t -butyl-5-arylpyrazoles . Heterocyclic Communications 23:2, pages 125-131.
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M. Sirajul Muneera & J. Joseph. (2016) Design, synthesis, structural elucidation, pharmacological evaluation of metal complexes with pyrazoline derivatives. Journal of Photochemistry and Photobiology B: Biology 163, pages 57-68.
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N. A. Keiko & N. V. Vchislo. (2016) Synthesis of Diheteroatomic Five-Membered Heterocyclic Compounds from α,β-Unsaturated Aldehydes. Asian Journal of Organic Chemistry 5:10, pages 1169-1197.
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V. N. Nuriev, I. A. Vatsadze, N. V. Sviridenkova & S. Z. Vatsadze. (2016) Synthesis of 3,7-disubstituted hexahydro- and tetrahydro-2H-indazoles from cross-conjugated dienones. Russian Journal of Organic Chemistry 52:3, pages 389-396.
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Mitsuhiro Kashiwa, Yoshiyuki Kuwata, Motohiro Sonoda & Shinji Tanimori. (2016) Oxone-mediated facile access to substituted pyrazoles. Tetrahedron 72:2, pages 304-311.
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Shamsuzzaman, Hena Khanam, Ayaz Mahmood Dar, Nazish Siddiqui & Sumbul Rehman. (2016) Synthesis, characterization, antimicrobial and anticancer studies of new steroidal pyrazolines. Journal of Saudi Chemical Society 20:1, pages 7-12.
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Dinabandhu Sar, Raghunath Bag, Afsana Yashmeen, Subhendu Sekhar Bag & Tharmalingam Punniyamurthy. (2015) Synthesis of Functionalized Pyrazoles via Vanadium-Catalyzed C–N Dehydrogenative Cross-Coupling and Fluorescence Switch-On Sensing of BSA Protein. Organic Letters 17:21, pages 5308-5311.
Crossref
Xinting Zhang, Jinfeng Kang, Pengfei Niu, Jie Wu, Wenquan Yu & Junbiao Chang. (2014) I 2 -Mediated Oxidative C–N Bond Formation for Metal-Free One-Pot Synthesis of Di-, Tri-, and Tetrasubstituted Pyrazoles from α,β-Unsaturated Aldehydes/Ketones and Hydrazines . The Journal of Organic Chemistry 79:21, pages 10170-10178.
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Dinabandhu Sar, Rajesh Paul, Mani Sengoden & Tharmalingam Punniyamurthy. (2014) Synthesis of Substituted Pyrazoles from Vinylhydrozones via Bromoamination and Hydroamination with 2,2,6,6‐Tetramethylpiperidine‐1‐oxyl and N ‐Bromosuccinimide . Asian Journal of Organic Chemistry 3:5, pages 638-643.
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Amal Rabahi, Safouane M. Hamdi, Yahia Rachedi, Maamar Hamdi, Oualid Talhi, Filipe A. Almeida Paz, Artur S.M. Silva, Balegroune Fadila, Hamadène Malika & Taïbi Kamel. (2014) 2D-NMR, X-ray crystallography and theoretical studies of the reaction mechanism for the synthesis of 1,5-benzodiazepines from dehydroacetic acid derivatives and o-phenylenediamines. Journal of Molecular Structure 1061, pages 97-103.
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E. A. Borodina, N. A. Orlova & V. V. Shelkovnikov. (2014) Synthesis of (N-acryloyl)piperazine-substituted polyfluorochalcones. Russian Chemical Bulletin 62:10, pages 2227-2233.
Crossref
Larry Yet. 2013. 217 256 .
Vidya G. Desai, Pooja C. Satardekar, Sampada Polo & Kashinath Dhumaskar. (2012) ChemInform Abstract: Regioselective Synthesis of 1,3,5‐Trisubstituted Pyrazoles.. ChemInform 43:32.
Crossref
Anjali Gupta, Sinthiya Gawandi, Inderjeet Yadav, Hari Mohan, Vidya G. Desai & Sachin Kumar. (2022) Analysis of Fluoro Based Pyrazole Analogues as a Potential Therapeutics Candidate Against Japanese Encephalitis Virus Infection. SSRN Electronic Journal.
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