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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 45, 2015 - Issue 20
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Original Articles

Synthesis of Novel 1,2,3-Triazole-dihydro[3,2-c]chromenones as Acetylcholinesterase Inhibitors

Mina SaeediMedicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran;Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
,
Shirin AnsariDepartment of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
,
Mohammad MahdaviDepartment of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
,
Reyhaneh SabourianPersian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
,
Tahmineh AkbarzadehPersian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran;Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
,
Alireza ForoumadiDepartment of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
&
Abbas ShafieeDepartment of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, IranCorrespondence[email protected]
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Pages 2311-2318 | Received 21 Apr 2015, Published online: 11 Sep 2015

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Amita J. Jivani, Kaushik S. Lunagariya, Khushal M. Kapadiya, Piyush V. Dholaria, Vijay M. Khedkar & Ranjan C. Khunt. (2022) A Step-By-Step Synthesis of S-Methylene Linker Containing Triazole-Benzoxazole Hybrids by Click Chemistry Approach: Anticancer Activity in Human Cells. Analytical Chemistry Letters 12:1, pages 44-57.
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Seyed Esmail Sadat-Ebrahimi, Seyed Mohammad Haghayegh-Zavareh, Saeed Bahadorikhalili, Azadeh Yahya-Meymandi, Mohammad Mahdavi & Mina Saeedi. (2017) Cu(II)-β-cyclodextrin-catalyzed synthesis of spiro[indoline-3,4′-pyrano[3,2-c]chromene]-3′-carbonitrile derivatives. Synthetic Communications 47:24, pages 2324-2329.
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Articles from other publishers (27)

Sorachat Tharamak, Tipanan Wisarutwanit, Weerasak Songoen, Patchreenart Saparpakorn & Wanchai Pluempanupat. (2023) Synthesis and Acetylcholinesterase Inhibitory Evaluation of Coumarin‐Linked Carbazole Derivatives. ChemistrySelect 8:46.
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Atamjit Singh, Karanvir Singh, Jashandeep Kaur, Ramanpreet Kaur, Aman Sharma, Jasleen Kaur, Uttam Kaur, Renu Chadha & Preet Mohinder Singh Bedi. (2023) Pathogenesis of Alzheimer’s Disease and Diversity of 1,2,3-Triazole Scaffold in Drug Development: Design Strategies, Structural Insights, and Therapeutic Potential. ACS Chemical Neuroscience 14:18, pages 3291-3317.
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Shah Alam Khan, Mohammad Jawaid Akhtar, Urvashee Gogoi, Dhanalekshmi Unnikrishnan Meenakshi & Aparoop Das. (2023) An Overview of 1,2,3-triazole-Containing Hybrids and Their Potential Anticholinesterase Activities. Pharmaceuticals 16:2, pages 179.
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Rakesh Singh, Harpreet Kaur & Pankaj Gupta. 1, 2, 3-triazole based conjugates-potential cholinesterase (AChE and BuChE) and BACE inhibitors for treatment of Alzheimer. 1, 2, 3-triazole based conjugates-potential cholinesterase (AChE and BuChE) and BACE inhibitors for treatment of Alzheimer.
Chandu Anantha Lakshmi Prasanna & Abha Sharma. (2022) Pharmacological Exploration of Triazole-based Therapeutics for Alzheimer’s Disease: An Overview. Current Drug Targets 23:9, pages 933-953.
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Arruje Hameed, Muhammad Abdul Qayyum, Abdur Rehman, Touseef Ur Rehman, Anwar Ahmad & Tahir Farooq. 2022. More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles. More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles 671 687 .
Asif Husain, Al Balushi K, Md Jawaid Akhtar & Shah Alam Khan. (2021) Coumarin linked heterocyclic hybrids: A promising approach to develop multi target drugs for Alzheimer's disease. Journal of Molecular Structure 1241, pages 130618.
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Adinath D. Badar, Shubham M. Sulakhe, Mahesh B. Muluk, Naziya N. M. A. Rehman, Prashant P. Dixit, Prafulla B. Choudhari, Giribala M. Bondle & Kishan P. Haval. (2021) Synthesis, Antimicrobial Evaluation and Docking Study of Novel Thiosemicarbazone Clubbed with 1,2,3-Triazoles. Current Bioactive Compounds 17:6.
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Zahra Haghighijoo, Sara Akrami, Mina Saeedi, Afsaneh Zonouzi, Aida Iraji, Bagher Larijani, Hossein Fakherzadeh, Farshad Sharifi, Seyed Masoud Arzaghi, Mohammad Mahdavi & Najmeh Edraki. (2020) N-Cyclohexylimidazo[1,2-a]pyridine derivatives as multi-target-directed ligands for treatment of Alzheimer's disease. Bioorganic Chemistry 103, pages 104146.
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Mohamed E. I. Badawy & Saad R. El-Zemity. (2020) 3D Pharmacophore-based Ligand Alignment, Virtual Screening and Molecular Docking Protocols Towards the Discovery of 2-((1H-1,2,4-triazol-1- yl)methyl) Derivatives as Antifungal Inhibitors. Current Bioactive Compounds 16:4, pages 498-513.
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Zohreh Bakherad, Maryam Mohammadi-Khanaposhtani, Hojjat Sadeghi-Aliabadi, Sepideh Rezaei, Afshin Fassihi, Mohammad Bakherad, Hossein Rastegar, Mahmood Biglar, Lotfollah Saghaie, Bagher Larijani & Mohammad Mahdavi. (2019) New thiosemicarbazide-1,2,3-triazole hybrids as potent α-glucosidase inhibitors: Design, synthesis, and biological evaluation. Journal of Molecular Structure 1192, pages 192-200.
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Maryam Mohammadi-Khanaposhtani, Kiana Fahimi, Elahe Karimpour-Razkenari, Maliheh Safavi, Mohammad Mahdavi, Mina Saeedi & Tahmineh Akbarzadeh. (2019) Design, Synthesis and Cytotoxicity of Novel Coumarin-1,2,3-triazole-1,2,4- Oxadiazole Hybrids as Potent Anti-breast Cancer Agents. Letters in Drug Design & Discovery 16:7, pages 818-824.
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Mohammad Mahdavi, Roshanak Hariri, Seyedeh Sara Mirfazli, Hania Lotfian, Arezoo Rastergari, Omidreza Firuzi, Najmeh Edraki, Bagher Larijani, Tahmineh Akbarzadeh & Mina Saeedi. (2019) Synthesis and Biological Activity of Some Benzochromenoquinolinones: Tacrine Analogs as Potent Anti‐Alzheimer's Agents. Chemistry & Biodiversity 16:4.
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D.S. Bhagat, S.G. Pande, M.V. Katariya, R.P. Pawar & P.S. Kendrekar. (2019) Microwave Assisted One Pot Synthesis of 3,4-Dihydropyrano[c]chromene Derivatives using [Emim]OH Ionic Liquid as Novel Catalyst. Asian Journal of Chemistry 31:4, pages 829-833.
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Arezoo Rastegari, Hamid Nadri, Mohammad Mahdavi, Alireza Moradi, Seyedeh Sara Mirfazli, Najmeh Edraki, Farshad Homayouni Moghadam, Bagher Larijani, Tahmineh Akbarzadeh & Mina Saeedi. (2019) Design, synthesis and anti-Alzheimer’s activity of novel 1,2,3-triazole-chromenone carboxamide derivatives. Bioorganic Chemistry 83, pages 391-401.
Crossref
Mina Saeedi, Maryam Mohammadi-Khanaposhtani, Parvaneh Pourrabia, Nima Razzaghi, Reza Ghadimi, Somaye Imanparast, Mohammad Ali Faramarzi, Fatemeh Bandarian, Ensieh Nasli Esfahani, Maliheh Safavi, Hossein Rastegar, Bagher Larijani, Mohammad Mahdavi & Tahmineh Akbarzadeh. (2019) Design and synthesis of novel quinazolinone-1,2,3-triazole hybrids as new anti-diabetic agents: In vitro α-glucosidase inhibition, kinetic, and docking study. Bioorganic Chemistry 83, pages 161-169.
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Bilqees Sameem, Mina Saeedi, Mohammad Mahdavi, Hamid Nadri, Fahimeh Vafadarnejad & Mohsen Amini. (2018) Synthesis and Characterization of Novel Phthalimide‐pyrano[3,2‐ c ]chromene and Phthalimide‐pyrano‐2‐one Hybrids . Journal of Heterocyclic Chemistry 55:7, pages 1678-1684.
Crossref
Mohammad Mahdavi, Arsalan Ashtari, Mahsima Khoshneviszadeh, Sara Ranjbar, Ameneh Dehghani, Tahmineh Akbarzadeh, Bagher Larijani, Mehdi Khoshneviszadeh & Mina Saeedi. (2018) Synthesis of New Benzimidazole‐1,2,3‐triazole Hybrids as Tyrosinase Inhibitors. Chemistry & Biodiversity 15:7.
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T. Jency Mohan & D. Bahulayan. (2017) Design, synthesis and fluorescence property evaluation of blue emitting triazole-linked chromene peptidomimetics. Molecular Diversity 21:3, pages 585-596.
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Mina Saeedi, Maliheh Safavi, Elahe Karimpour-Razkenari, Mohammad Mahdavi, Najmeh Edraki, Farshad Homayouni Moghadam, Mahnaz Khanavi & Tahmineh Akbarzadeh. (2017) Synthesis of novel chromenones linked to 1,2,3-triazole ring system: Investigation of biological activities against Alzheimer’s disease. Bioorganic Chemistry 70, pages 86-93.
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Zahra Najafi, Mohammad Mahdavi, Mina Saeedi, Elahe Karimpour-Razkenari, Raymond Asatouri, Fahimeh Vafadarnejad, Farshad Homayouni Moghadam, Mahnaz Khanavi, Mohammad Sharifzadeh & Tahmineh Akbarzadeh. (2017) Novel tacrine-1,2,3-triazole hybrids: In vitro, in vivo biological evaluation and docking study of cholinesterase inhibitors. European Journal of Medicinal Chemistry 125, pages 1200-1212.
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Roshanak Hariri, Zahra Afshar, Mohammad Mahdavi, Maliheh Safavi, Mina Saeedi, Zahra Najafi, Reyhaneh Sabourian, Elahe Karimpour‐Razkenari, Najmeh Edraki, Farshad Homayouni Moghadam, Abbas Shafiee, Mahnaz Khanavi & Tahmineh Akbarzadeh. (2016) Novel Tacrine‐Based Pyrano[3’,4’:5,6]pyrano[2,3‐ b ]quinolinones: Synthesis and Cholinesterase Inhibitory Activity . Archiv der Pharmazie 349:12, pages 915-924.
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Zahra Najafi, Mina Saeedi, Mohammad Mahdavi, Reyhaneh Sabourian, Mahnaz Khanavi, Maliheh Barazandeh Tehrani, Farshad Homayouni Moghadam, Najmeh Edraki, Elahe Karimpor-Razkenari, Mohammad Sharifzadeh, Alireza Foroumadi, Abbas Shafiee & Tahmineh Akbarzadeh. (2016) Design and synthesis of novel anti-Alzheimer’s agents: Acridine-chromenone and quinoline-chromenone hybrids. Bioorganic Chemistry 67, pages 84-94.
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Mohammad Mahdavi, Samira Mohammadi-Izad, Mina Saeedi, Maliheh Safavi, Seyed Esmaeil Sadat Ebrahimi, Alireza Foroumadi & Abbas Shafiee. (2016) Synthesis and cytotoxicity of novel chromenone derivatives bearing 4-nitrophenoxy phenyl acryloyl moiety. Journal of the Iranian Chemical Society 13:6, pages 1139-1144.
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Mina Saeedi, Maedeh Golipoor, Mohammad Mahdavi, Alireza Moradi, Hamid Nadri, Saeed Emami, Alireza Foroumadi & Abbas Shafiee. (2016) Phthalimide‐Derived N ‐Benzylpyridinium Halides Targeting Cholinesterases: Synthesis and Bioactivity of New Potential Anti‐Alzheimer's Disease Agents . Archiv der Pharmazie 349:4, pages 293-301.
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Mohammad Mahdavi, Hosein Lijan, Saeed Bahadorikhalili, Leila Ma’mani, Parviz Rashidi Ranjbar & Abbas Shafiee. (2016) Copper supported β-cyclodextrin grafted magnetic nanoparticles as an efficient recyclable catalyst for one-pot synthesis of 1-benzyl-1H-1,2,3-triazoldibenzodiazepinone derivatives via click reaction. RSC Advances 6:34, pages 28838-28843.
Crossref
Clementina M.M. Santos & Artur M.S. Silva. 2016. 523 578 .

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