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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 46, 2016 - Issue 20
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Original Articles

Efficient and scalable process for the synthesis of antihypercholesterolemic drug ezetimibe

Yijun ZhuState Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Key Laboratory of Anti-infectives, State Institute of Pharmaceutical Industry, Shanghai, China;School of Pharmacy, Fudan University, Shanghai, China
,
Jing PanState Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Key Laboratory of Anti-infectives, State Institute of Pharmaceutical Industry, Shanghai, China
,
Shunli ZhangState Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Key Laboratory of Anti-infectives, State Institute of Pharmaceutical Industry, Shanghai, China
,
Zhenren LiuState Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Key Laboratory of Anti-infectives, State Institute of Pharmaceutical Industry, Shanghai, China
,
Deyong YeSchool of Pharmacy, Fudan University, Shanghai, ChinaCorrespondence[email protected]
&
Weicheng ZhouState Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Key Laboratory of Anti-infectives, State Institute of Pharmaceutical Industry, Shanghai, ChinaCorrespondence[email protected]
Pages 1687-1693 | Received 08 Apr 2016, Published online: 30 Sep 2016

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Zheng Lu, Yong-Qing Yang, Jiu-Hui Li, Jun-Nan Wei & Yi-Zhu Wang. (2017) Convenient approach to chiral 4-monosubstituted 1,3-oxazolidine-2-thiones. Synthetic Communications 47:23, pages 2215-2219.
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Masahiro Hosoya, Atsushi Manaka, Takahiro Kawajiri & Takafumi Ohara. (2024) Application of Taylor Vortex Flow Reactor Enabling Precise Control of Nucleation in Reactive Crystallization. Organic Process Research & Development.
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Pengfei Xu, Lijun Zhu, Desheng Zhang, Zilong Li, Raoling Ge & Qiang Tian. (2024) Design and synthesis of fluorine aromatic scaffolds containing drugs approved by the US FDA from 2002 to 2022. Results in Chemistry 7, pages 101446.
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Durgababu Rapeti, Kapavarapu Maruthi Venkata Narayanarao, Pulipaka Shyamala & Rallabhandi Murali Krishna. (2021) Identification of the Organic Volatile Impurities in Ezitamibe using GC-HS Technique. Asian Journal of Chemistry 33:3, pages 605-610.
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Kazuyuki Sato, Motoyuki Isoda, Atsushi Tarui & Masaaki Omote. (2020) Reductive Carbon–Carbon Bond Forming Reactions with Carbonyls Mediated by Rh–H Complexes. European Journal of Organic Chemistry 2020:42, pages 6503-6511.
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Pedro Paulo Santos & William Heggie. 2020. Retrosynthesis in the Manufacture of Generic Drugs. Retrosynthesis in the Manufacture of Generic Drugs 207 274 .
Yun-Yu Hua, Huai-Yu Bin, Tao Wei, Hou-An Cheng, Zu-Peng Lin, Xing-Feng Fu, Yuan-Qiang Li, Jian-Hua Xie, Pu-Cha Yan & Qi-Lin Zhou. (2020) Iridium-Catalyzed Asymmetric Hydrogenation of γ- and δ-Ketoacids for Enantioselective Synthesis of γ- and δ-Lactones. Organic Letters 22:3, pages 818-822.
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Kenneth J. Fraunhoffer, Albert J. DelMonte, Gregory L. Beutner, Michael S. Bultman, Kathryn Camacho, Benjamin Cohen, Darryl D. Dixon, Yu Fan, Dayne Fanfair, Adam J. Freitag, Andrew W. Glace, Francisco Gonzalez-Bobes, Manjunath Gujjar, Matthew W. Haley, Matthew R. Hickey, Jeanne Ho, Vidya Iyer, Prantik Maity, Sunil Patel, Victor W. Rosso, Michael A. Schmidt, Jason M. Stevens, Yichen Tan, Christopher Wilbert, Ian S. Young & Miao Yu. (2019) Rapid Development of a Commercial Process for Linrodostat, an Indoleamine 2,3-Dioxygenase (IDO) Inhibitor. Organic Process Research & Development 23:11, pages 2482-2498.
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Nanwei Wan, Jiawei Tian, Xiaoying Zhou, Huihui Wang, Baodong Cui, Wenyong Han & Yongzheng Chen. (2019) Regioselective Ring‐Opening of Styrene Oxide Derivatives Using Halohydrin Dehalogenase for Synthesis of 4‐Aryloxazolidinones. Advanced Synthesis & Catalysis 361:20, pages 4651-4655.
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Yang Hu, Xuguang Yin, Ziyi Chen, Xiu-Qin Dong & Xumu Zhang. (2018) Highly enantioselective Ir/f-amphox-catalyzed hydrogenation of ketoamides: efficient access to chiral hydroxy amides. Organic Chemistry Frontiers 5:12, pages 2000-2003.
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