Advanced search
Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 47, 2017 - Issue 16
Submit an article Journal homepage
856
Views
38
CrossRef citations to date
0
Altmetric
Original Articles

Design, synthesis of new pyrimidine derivatives as anticancer and antimicrobial agents

Mohamed M. MohamedDepartment of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt
,
Ali K. KhalilDepartment of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt
,
Eslam M. AbbassDepartment of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt
&
Abeer M. El-NaggarDepartment of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo, EgyptCorrespondence[email protected]
Pages 1441-1457 | Received 07 Mar 2017, Published online: 30 Jun 2017

Citations (38)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Mona S. El-Zoghbi, Samiha A. El-Sebaey, Hanan A. AL-Ghulikah & Eman A. Sobh. (2023) Design, synthesis, docking, and anticancer evaluations of new thiazolo[3,2-a] pyrimidines as topoisomerase II inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
Read now
Nitin Rode, Aafaq Tantray, Amruta Shelar, Rajendra Patil & Santosh Terdale. (2022) Amino acid ionic liquid-catalyzed synthesis, anti-Leishmania activity, molecular docking, molecular dynamic simulation, and ADME study of 3,4-dihydropyrimidin-2(1H)-(thio)ones. Synthetic Communications 52:2, pages 190-204.
Read now

Articles from other publishers (36)

Serhiy M. Desenko, Mykola Yu. Gorobets, Victoria V. Lipson, Yana I. Sakhno & Valentyn A. Chebanov. (2023) Dihydroazolopyrimidines: Past, Present and Perspectives in Synthesis, Green Chemistry and Drug Discovery. The Chemical Record.
Crossref
Artem S. Agarkov, Dilyara O. Mingazhetdinova, Anna A. Nefedova, Alexander S. Ovsyannikov, Andrey K. Shiryaev, Igor A. Litvinov, Svetlana E. Solovieva & Igor S. Antipin. (2023) Synthesis and Structure of 6-Acetyl-2-Arylhydrazone Derivatives of Thiazolo[3,2-a]Pyrimidine. Organics 4:3, pages 438-446.
Crossref
Akshun Vyas, Bhaskar Sahu, Shelly Pathania, Nilay Kumar Nandi, Gaurav Chauhan, Vivek Asati & Bhupinder Kumar. (2022) An insight on medicinal attributes of pyrimidine scaffold: An updated review. Journal of Heterocyclic Chemistry 60:7, pages 1081-1121.
Crossref
Manel Ben Hassen, Dhouha Msalbi, Badr Jismy, Fares Elghali, Sami Aifa, Hassan Allouchi, Mohamed Abarbri & Fakher Chabchoub. (2023) Three Component One-Pot Synthesis and Antiproliferative Activity of New [1,2,4]Triazolo[4,3-a]Pyrimidines. Molecules 28:9, pages 3917.
Crossref
A. S. Agarkov, A. K. Shiryaev, S. E. Solovieva & I. S. Antipin. (2023) Synthesis, Chemical Properties, and Application of 2-Substituted Thiazolo[3,2-a]pyrimidine Derivatives. Russian Journal of Organic Chemistry 59:3, pages 337-364.
Crossref
Rajapandi Raju, Kumarappan Chidambaram, Balakumar Chandrasekaran, Mohammad F. Bayan, Tapan Kumar Maity, Abdullah M. Alkahtani & Harish C Chandramoorthy. (2023) Synthesis, pharmacological evaluation, and molecular modeling studies of novel isatin hybrids as potential anticancer agents. Journal of Saudi Chemical Society 27:2, pages 101598.
Crossref
Artem S. Agarkov, Anna A. Nefedova, Elina R. Gabitova, Dilyara O. Mingazhetdinova, Alexander S. Ovsyannikov, Daut R. Islamov, Syumbelya K. Amerhanova, Anna P. Lyubina, Alexandra D. Voloshina, Igor A. Litvinov, Svetlana E. Solovieva & Igor S. Antipin. (2023) (2-Hydroxy-3-Methoxybenzylidene)thiazolo[3,2-a]pyrimidines: Synthesis, Self-Assembly in the Crystalline Phase and Cytotoxic Activity. International Journal of Molecular Sciences 24:3, pages 2084.
Crossref
Rajapandi Raju, Kumarappan Chidambaram, Balakumar Chandrasekaran & Tapan Kumar Maity. (2023) RETRACTED ARTICLE: Synthesis, Pharmacological Evaluation, and Molecular Modeling Studies of New Isatin Hybrids as Potential Anticancer Agents. Pharmaceutical Chemistry Journal 56:10, pages 1389-1399.
Crossref
Eman A. Sobh, Nadia A. Khalil, Samar I. Faggal & Marwa S. A. Hassan. (2022) New benzothienopyrimidine derivatives as dual EGFR/ARO inhibitors: Design, synthesis, and their cytotoxic effect on MCF‐7 breast cancer cell line. Drug Development Research 83:5, pages 1075-1096.
Crossref
Grace Shaji Chittilappilly, Meena Chandran & Kunnanbath Krishnakumar. (2022) Multiple and One-Pot Synthetic Strategies for Pyrimido-Thiazine and their Derivatives. Current Organic Chemistry 26:14, pages 1321-1332.
Crossref
Xiaqian Wu, Peng Ma & Jianhui Wang. (2022) Copper‐catalyzed direct synthesis of arylated 8‐aminoquinolines through chelation assistance. Applied Organometallic Chemistry 36:4.
Crossref
Ahmed M. Abo-Bakr, Hesham M. Alsoghier & Aboubakr H. Abdelmonsef. (2022) Molecular docking, modeling, semiempirical calculations studies and in vitro evaluation of new synthesized pyrimidin-imide derivatives. Journal of Molecular Structure 1249, pages 131548.
Crossref
Ravindra P. Sonawane, Vikas Sikervar & Swarnendu Sasmal. 2022. Comprehensive Heterocyclic Chemistry IV. Comprehensive Heterocyclic Chemistry IV 181 283 .
Amol D. Sonawane & Mamoru Koketsu. 2022. Comprehensive Heterocyclic Chemistry IV. Comprehensive Heterocyclic Chemistry IV 859 879 .
PRANALI A JADHAV & ATUL BARAVKAR. (2021) RECENT ADVANCES IN ANTIMICROBIAL ACTIVITY OF PYRIMIDINES: A REVIEW. Asian Journal of Pharmaceutical and Clinical Research, pages 4-10.
Crossref
Anastasia A. Babushkina, Albina V. Dogadina, Dmitrij M. Egorov, Julia L. Piterskaia, Anna A. Shtro, Yulia V. Nikolaeva, Anastasia V. Galochkina, Anton A. Kornev & Vitali M. Boitsov. (2021) Efficient synthesis and evaluation of antiviral and antitumor activity of novel 3-phosphonylated thiazolo[3,2-a]oxopyrimidines. Medicinal Chemistry Research 30:12, pages 2203-2215.
Crossref
A.A.M. Farag, Nadia A.A. Elkanzi, A.H. Ammar & N. Roushdy. (2021) Performance and photoresponse characterizations of pyrimidine quinolone carboxylate derivatives films-based heterojunction devices. Optik 231, pages 166426.
Crossref
Mohamed T.M. Nemr, Amr Sonousi & Adel A. Marzouk. (2020) Design, synthesis and antiproliferative evaluation of new tricyclic fused thiazolopyrimidines targeting topoisomerase II: Molecular docking and apoptosis inducing activity. Bioorganic Chemistry 105, pages 104446.
Crossref
A. A. Babushkina, D. M. Egorov & K. I. Kaskevich. (2020) Synthesis and Functionalization of 5-Alkyl-6-methyl-2-thiouracils. Russian Journal of General Chemistry 90:11, pages 2093-2097.
Crossref
Mohamed T.M. Nemr & Asmaa M. AboulMagd. (2020) New fused pyrimidine derivatives with anticancer activity: Synthesis, topoisomerase II inhibition, apoptotic inducing activity and molecular modeling study. Bioorganic Chemistry 103, pages 104134.
Crossref
Marwa H. Ahmed, Maher A. El‐Hashash, Magda I. Marzouk & Abeer M. El‐Naggar. (2020) Synthesis and antitumor activity of some nitrogen heterocycles bearing pyrimidine moiety. Journal of Heterocyclic Chemistry 57:9, pages 3412-3427.
Crossref
Wang Haoran, Wasim Akhtar, Lalit Mohan Nainwal, Sumit Kumar Kaushik, Mymoona Akhter, Mohammad Shaquiquzzaman & Mohammad Mumtaz Alam. (2020) Synthesis and biological evaluation of benzimidazole pendant cyanopyrimidine derivatives as anticancer agents. Journal of Heterocyclic Chemistry 57:9, pages 3350-3360.
Crossref
Ksenia I Kaskevich, Anastasia A Babushkina, Vladislav V Gurzhiy, Dmitrij M Egorov, Nataly I Svintsitskaya & Albina V Dogadina. (2020) Synthesis of 3(2)-phosphonylated thiazolo[3,2- a ]oxopyrimidines . Beilstein Journal of Organic Chemistry 16, pages 1947-1954.
Crossref
Nadia A.A. Elkanzi, A.A.M. Farag, N. Roushdy & A.M. Mansour. (2020) Design, fabrication and optical characterizations of pyrimidine fused quinolone carboxylate moiety for photodiode applications. Optik 216, pages 164882.
Crossref
Hayat E. Alzahrani, Ahmed M. Fouda & Ayman M. S. Youssef. (2019) Selective cyclization of S‐substituted pyrimidinethione: Synthesis and antimicrobial evaluation of novel polysubstituted thiazolopyrimidine and thiazolodipyrimidine derivatives. Journal of the Chinese Chemical Society 67:5, pages 838-855.
Crossref
Fatma A. Ragab, Yassin M. Nissan, Emad M. Seif, Ahmed Maher & Reem K. Arafa. (2020) Synthesis and in vitro investigation of novel cytotoxic pyrimidine and pyrazolopyrimidne derivatives showing apoptotic effect. Bioorganic Chemistry 96, pages 103621.
Crossref
Eslam M. Abbass, Ali Kh. Khalil & Abeer M. El‐Naggar. (2020) Eco‐friendly synthesis of novel pyrimidine derivatives as potential anticancer agents. Journal of Heterocyclic Chemistry 57:3, pages 1154-1164.
Crossref
Nadia A. Khalil, Eman M. Ahmed, Ashraf F. Zaher, Mona S. El-Zoghbi & Eman A. Sobh. (2020) Synthesis of certain benzothieno[3,2-d]pyrimidine derivatives as a selective SIRT2 inhibitors. European Journal of Medicinal Chemistry 187, pages 111926.
Crossref
Mohamed Fares, Patrick M. McCosker, Muhammad A. Alsherbiny, Anthony C. Willis, Timothy Clark, Johan Neyts, Dirk Jochmans & Paul A. Keller. (2020) Regioselective convergent synthesis of 2-arylidene thiazolo[3,2- a ]pyrimidines as potential anti-chikungunya agents . RSC Advances 10:9, pages 5191-5195.
Crossref
Pradip Kumar Maji. (2019) Synthesis of Pyrimidine-Annulated Five-Membered Heterocycles: An Overview. Current Organic Chemistry 23:20, pages 2204-2269.
Crossref
N.S. El-Gohary, S.S. Hawas, M.T. Gabr, M.I. Shaaban & M.B. El-Ashmawy. (2019) New series of fused pyrazolopyridines: Synthesis, molecular modeling, antimicrobial, antiquorum-sensing and antitumor activities. Bioorganic Chemistry 92, pages 103109.
Crossref
Lamia H.T. Amin, Taghreed Z. Shawer, Abeer M. El-Naggar & Hend M.A. El-Sehrawi. (2019) Design, synthesis, anticancer evaluation and docking studies of new pyrimidine derivatives as potent thymidylate synthase inhibitors. Bioorganic Chemistry 91, pages 103159.
Crossref
Chonghui Ma, Yunyun Wang, Fuhao Dong, Zhonglong Wang, Yuxun Zhao, Yu Shan, Wen Gu & Shifa Wang. (2019) Synthesis and antitumor activity of isolongifoleno[7,8‐ d ]thiazolo[3,2‐ a ]pyrimidine derivatives via enhancing ROS level . Chemical Biology & Drug Design.
Crossref
Alaa A. Abd Elhameed, Nadia S. El-Gohary, Eman R. El-Bendary, Mona I. Shaaban & Said M. Bayomi. (2018) Synthesis and biological screening of new thiazolo[4,5-d]pyrimidine and dithiazolo[3,2-a:5′,4′-e]pyrimidinone derivatives as antimicrobial, antiquorum-sensing and antitumor agents. Bioorganic Chemistry 81, pages 299-310.
Crossref
Srinubabu Maddela, Ajitha Makula, Mario D. Galigniana, Della G. T. Parambi, Fernando Federicci, Gisela Mazaira, Omnia M. Hendawy, Sanal Dev, Githa E. Mathew & Bijo Mathew. (2018) Fe 3 O 4 nanoparticles mediated synthesis of novel spirooxindole-dihydropyrimidinone molecules as Hsp90 inhibitors . Archiv der Pharmazie, pages 1800174.
Crossref
Amira A. Helwa, Ehab M. Gedawy, Sahar M. Abou-Seri, Azza T. Taher & Afaf K. El-Ansary. (2018) Synthesis and bioactivity evaluation of new pyrimidinone-5-carbonitriles as potential anticancer and antimicrobial agents. Research on Chemical Intermediates 44:4, pages 2685-2702.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.