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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 6
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Original Articles

Efficient syntheses of zoledronic acid as an active ingredient of a drug against osteoporosis

Dávid Illés NagyDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, HungaryView further author information
,
Alajos GrünDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, HungaryView further author information
,
Krisztina LévayDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, HungaryView further author information
,
Sándor GaradnayGedeon Richter Plc., Budapest, HungaryView further author information
,
István GreinerGedeon Richter Plc., Budapest, HungaryView further author information
&
György KeglevichDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, HungaryCorrespondence[email protected]
View further author information
Pages 663-671 | Received 26 Oct 2017, Published online: 13 Feb 2018

Citations (9)

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Read on this site (2)

György Keglevich, Zsuzsanna Szalai, Kinga V. Gulyás, Róbert Zahár, Alajos Grün & Csilla Sepsey Für. (2022) The synthesis of hydroxymethylenebisphosphonic- (dronic-) and acyl-ethoxycarbonyl-methylphosphonate derivatives. Phosphorus, Sulfur, and Silicon and the Related Elements 197:5-6, pages 520-522.
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Alajos Grün, Zita Rádai, Dávid Illés Sőregi-Nagy, István Greiner & György Keglevich. (2019) Rational synthesis of α-hydroxyphosphonic derivatives including dronic acids. Phosphorus, Sulfur, and Silicon and the Related Elements 194:4-6, pages 386-387.
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Articles from other publishers (7)

Hongchi YI, Tao CHEN, Jiming GAN, Zhuoqian DONG, Dun LIU, Yuanzhi ZHENG, Huijun NING & Qingzhong WEI. (2024) Effects of percutaneous kyphoplasty combined with zoledronic acid injection on osteoporotic vertebral compression fracture and bone metabolism indices. Journal of Neurosurgical Sciences 68:1.
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Zsuzsanna Szalai, Boldizsár Tóth, Rita Oláhné Szabó, Szilvia Bősze, Konstantin Karaghiosoff, Mátyás Czugler, László Drahos & György Keglevich. (2023) A Study of the Bisphosphonic Derivatives from the Pudovik Reaction of Dialkyl α-Oxophosphonates and >P(O)H Reagents: X-ray Structure and Bioactivity. Molecules 28:16, pages 6037.
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Frank H. Ebetino, Shuting Sun, Philip Cherian, Sahar Roshandel, Jeffrey D. Neighbors, Eric Hu, James E. Dunford, Parish P. Sedghizadeh, Charles E. McKenna, Venkat Srinivasan, Robert K. Boeckman & R. Graham G. Russell. (2022) Bisphosphonates: The role of chemistry in understanding their biological actions and structure-activity relationships, and new directions for their therapeutic use. Bone 156, pages 116289.
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Péter Ábrányi-Balogh, István Greiner & György Keglevich. (2021) A Mechanistic Study on the Formation of Dronic Acids. Molecules 26:24, pages 7587.
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Alajos Grün, Zsuzsanna Szalai & György Keglevich. (2021) “Greener” Synthesis of Zoledronic Acid from Imidazol-1-yl-acetic Acid and P-Reagents Using Diethyl Carbonate as the Solvent Component. Letters in Organic Chemistry 18:1, pages 8-12.
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Jéssica S. Barbosa, Susana Santos Braga & Filipe A. Almeida Paz. (2020) Empowering the Medicinal Applications of Bisphosphonates by Unveiling their Synthesis Details. Molecules 25:12, pages 2821.
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Dávid Illés Nagy, Alajos Grün, Júlia Sinkovicz, Sándor Garadnay, István Greiner & György Keglevich. (2019) A Study on the Synthesis of Risedronic Acid: The Role of an Ionic Liquid Additive. Letters in Drug Design & Discovery 16:3, pages 238-244.
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