Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 10
795
Views
55
CrossRef citations to date
0
Altmetric
SYNTHETIC COMMUNICATIONS REVIEWS

Current perspectives on quinazolines with potent biological activities: A review

, , , , & ORCID Icon
Pages 1099-1127 | Received 08 Dec 2017, Published online: 16 Mar 2018

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Dina G. Sanad, Ahmed S. A. Youssef, Fatma A. El-Mariah & Heba E. Hashem. (2023) Synthesis, Molecular Docking Study, and ADMET Properties of New Antimicrobial Quinazolinone and Fused Quinazoline Derivatives. Polycyclic Aromatic Compounds 43:4, pages 3051-3071.
Read now

Articles from other publishers (54)

Michal Hricovíni, Zuzana Hricovíniová & Ján Moncoľ. (2024) Spectroscopic properties, crystal structure, Hirshfeld surface analysis and DFT study of a new Cu(II) complex based on quinazolinone O,N,O-donor ligand. Journal of Molecular Structure 1306, pages 137886.
Crossref
Ali Gamal Al-Kaf. 2024. Recent Advances on Quinazoline. Recent Advances on Quinazoline.
Jiwei Wu, Jun He, Jingjing Wang, Lixia Li, Caiyu Xu, Jie Zhou, Zirong Li & Huajian Xu. (2024) Electrochemical Oxidation Decarboxylative Cyclization of α -Keto Acid with o -Aminobenzylamine . Chinese Journal of Organic Chemistry 44:3, pages 972.
Crossref
Igor Yu Grishin, Alexander V. Aksenov, Nicolai A. Aksenov, Yuriy I. Grishin, Alexander V. Leontiev & Dmitrii A. Aksenov. (2024) One-step synthesis of 4-methyl-2-substituted quinazoline-3-oxides via polyphosphoric acid catalyzed acylation of electron-rich anilides with nitroethane. Tetrahedron 151, pages 133784.
Crossref
M. I. Valieva, S. S. Rybakova, E. A. Kudryashova, M. Rahman, S. Santra, D. S. Kopchuk, E. V. Nosova, E. B. Gorbunov, G. V. Zyryanov & O. N. Chupakhin. (2024) Cyclocondensation of anthranilic acids with generated in situ methyl pyrimidine-2-carbimidate in the synthesis of 2-(pyrimidin-2-yl)quinazolin-4(3H)-ones. Russian Chemical Bulletin 72:12, pages 2974-2978.
Crossref
Leila Hasani, Elham Ezzatzadeh & Zinatossadat Hossaini. (2023) Green synthesis of new quinolinoquinazoline derivatives via one‐pot multicomponent reactions using ZnO / TiO 2 @ MWCNTs as a new nanocatalyst . Journal of Heterocyclic Chemistry 60:12, pages 2023-2035.
Crossref
Zhao-Yi Qin, Chen-Xi Sun, Wen-Wen Zhang, Jun-Ru Li, Yin-Xiang Gong, Wen-Ming Shu & An-Xin Wu. (2023) Efficient Synthesis of 2-Aminoquinazoline Derivatives via Acid-Mediated [4+2] Annulation of N-Benzyl Cyanamides. Catalysts 13:11, pages 1447.
Crossref
Fuqiang Yu, Ying Xu, Hao Wang, Lingling Chi, Xiaojie Si, Chao Gao, Honglin Dai, Limin Liu, Zhengjie Wang, Yu Ke, Hongmin Liu & Qiurong Zhang. (2023) Design, synthesis and antitumor activity evaluation of 4,6,7-trisubstituted quinazoline derivatives containing benzothiazole moiety. Medicinal Chemistry Research 32:10, pages 2156-2167.
Crossref
Rong Zeng, Cong Huang, Jie Wang, Yuan Zhong, Qingwen Fang, Shuzhen Xiao, Xuliang Nie, Shangxing Chen & Dayong Peng. (2023) Synthesis, Crystal Structure, and Antifungal Activity of Quinazolinone Derivatives. Crystals 13:8, pages 1254.
Crossref
Sangeeta Kalita, Niharika Kashyap, Debanga Bhusan Bora, Sukanya Das & Ruli Borah. (2023) Investigation of N,N′‐Disulfopiperazinium Chlorometallates of Fe(III), Ni(II) and Co(II) as Hybrid Catalysts for the Synthesis of 1,2‐Dihydroquinazoline Derivatives. ChemistrySelect 8:18.
Crossref
Aditya Raj, Adarsh Kumar, Ankit Kumar Singh, Harshwardhan Singh, Suresh Thareja & Pradeep Kumar. (2023) Synthetic Methodologies and SAR of Quinazoline Derivatives as PI3K Inhibitors. Anti-Cancer Agents in Medicinal Chemistry 23:9, pages 1013-1047.
Crossref
Mohamed F. Zayed. (2023) Medicinal Chemistry of Quinazolines as Anticancer Agents Targeting Tyrosine Kinases. Scientia Pharmaceutica 91:2, pages 18.
Crossref
Xiaodan Chang, Liangxin Fan, Lijun Shi, Zhenliang Pan, Guoyu Yang, Cuilian Xu, Lulu Wu & Caixia Wang. (2023) Catalyst- and solvent-free coupling of 2-methyl quinazolinones and 3-(trifluoroacetyl)coumarins: An environmentally benign access of quinazolinone derivatives. Journal of Saudi Chemical Society 27:2, pages 101621.
Crossref
Mehdi Riyahinia, Zahra Sadat Nazifi, Hamidreza Aghaei & Ahmad Reza Massah. (2022) Preparation of a novel acidic functionalized diatomite and its catalytic application in the synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives. Research on Chemical Intermediates 49:3, pages 979-995.
Crossref
Yanan Wu, Hongyi Zhao, Haihong Huang & Dongfeng Zhang. (2023) Mild synthesis of quinazolines from 2,2,2-trichloroethyl imidates and 2-aminophenyl ketones. Tetrahedron Letters 116, pages 154313.
Crossref
Shekh Sabir, Theerthankar Das, Rajesh Kuppusamy, Tsz Tin Yu, Mark DP Willcox, David StC Black & Naresh Kumar. (2023) Novel quinazolinone disulfide analogues as pqs quorum sensing inhibitors against Pseudomonas aeruginosa. Bioorganic Chemistry 130, pages 106226.
Crossref
Jeremy M. Kelm, Hariprasad Aruri, Prasanth R. Nyalapatla & Navnath S. Gavande. 2023. Fused Pyrimidine-Based Drug Discovery. Fused Pyrimidine-Based Drug Discovery 165 191 .
Pradeep Kumar, Rakesh Kumar & Raj Kumar. 2023. Fused Pyrimidine-Based Drug Discovery. Fused Pyrimidine-Based Drug Discovery 1 11 .
Mohamed F. Zayed. (2022) Medicinal Chemistry of Quinazolines as Analgesic and Anti-Inflammatory Agents. ChemEngineering 6:6, pages 94.
Crossref
Hesham A. M. Gomaa. (2022) A comprehensive review of recent advances in the biological activities of quinazolines. Chemical Biology & Drug Design 100:5, pages 639-655.
Crossref
Natália M. Moreira, Jhonathan R. N. dos Santos & Arlene G. Corrêa. (2022) Greener Synthesis of Pyrroloquinazoline Derivatives: Recent Advances. European Journal of Organic Chemistry 2022:35.
Crossref
Biplob Borah, Sidhartha Swain, Mihir Patat & L. Raju Chowhan. (2022) Recent advances and prospects in the organocatalytic synthesis of quinazolinones. Frontiers in Chemistry 10.
Crossref
Tatyana N. Moshkina, Emiliya V. Nosova, Alexandra E. Kopotilova, Maria I. Savchuk, Igor L. Nikonov, Dmitry S. Kopchuk, Pavel A. Slepukhin, Grigory A. Kim, Galina N. Lipunova & Valery N. Charushin. (2022) Synthesis and photophysical properties of pyridyl- and quinolinyl-substituted 4-(4-aminophenyl)quinazolines. Journal of Photochemistry and Photobiology A: Chemistry 429, pages 113917.
Crossref
Mainak Banerjee, Padmini C. Panjikar, Dharmendra Das, Shruti Iyer, Akhil A. Bhosle & Amrita Chatterjee. (2022) Grindstone chemistry: A “green” approach for the synthesis and derivatization of heterocycles. Tetrahedron 112, pages 132753.
Crossref
Pennamuthiriyan Anandaraj, Rengan Ramesh & Thangavel Sathiya Kamatchi. (2022) N^N^O hydrazone capped pincer type palladium complex catalysed construction of quinazolinones from alcohols. Inorganic Chemistry Communications 137, pages 109190.
Crossref
Hossein Ghafuri, Zahra Nasri & Zeinab Tajik. (2022) 1,4-Butane-Sultone Functionalized Graphitic Carbon Nitride as a Highly Efficient Heterogeneous Catalyst for the Synthesis of 2,3-Dihydroquinazolines Derivatives. 1,4-Butane-Sultone Functionalized Graphitic Carbon Nitride as a Highly Efficient Heterogeneous Catalyst for the Synthesis of 2,3-Dihydroquinazolines Derivatives.
Rameshwar S. Cheke, Sachin D. Shinde, Jaya P. Ambhore, Suraj R. Chaudhari & Sanjay B. Bari. (2022) Quinazoline: An update on current status against convulsions. Journal of Molecular Structure 1248, pages 131384.
Crossref
M.Carolina A. Carreira, M. Conceição Oliveira & Ana C. Fernandes. (2022) One-pot sustainable synthesis of valuable nitrogen compounds from biomass resources. Molecular Catalysis 518, pages 112094.
Crossref
Jenifer Robinson, Neeraj Kumari, VK Srivastava, Natalia Taskaeva & Chandra Mohan. (2022) Sustainable and environmental friendly energy materials. Materials Today: Proceedings 69, pages 494-498.
Crossref
Rodolfo H V Nishimura, Thiago dos Santos, Valter E Murie, Luciana C Furtado, Leticia V Costa-Lotufo & Giuliano C Clososki. (2021) Efficient N -arylation of 4-chloroquinazolines en route to novel 4-anilinoquinazolines as potential anticancer agents . Beilstein Journal of Organic Chemistry 17, pages 2968-2975.
Crossref
Alexander Spasov, Alexander Ozerov, Pavel Vassiliev, Vadim Kosolapov, Natalia Gurova, Aida Kucheryavenko, Ludmila Naumenko, Denis Babkov, Viktor Sirotenko, Alena Taran, Roman Litvinov, Alexander Borisov, Vladlen Klochkov, Darya Merezhkina, Mikhail Miroshnikov, Georgy Uskov & Nadezhda Ovsyankina. (2021) Synthesis and multifaceted pharmacological activity of novel quinazoline NHE-1 inhibitors. Scientific Reports 11:1.
Crossref
Subrata Sahoo & Shantanu Pal. (2021) Copper-Catalyzed One-Pot Synthesis of Quinazolinones from 2-Nitrobenzaldehydes with Aldehydes: Application toward the Synthesis of Natural Products. The Journal of Organic Chemistry 86:24, pages 18067-18080.
Crossref
Chun Huang, You Zhou, Xiao-Xiao Yu, Li-Sheng Wang, Yan-Dong Wu & An-Xin Wu. (2021) I 2 /CuCl 2 -Copromoted Formal [4 + 1 + 1] Cyclization of Methyl Ketones, 2-Aminobenzonitriles, and Ammonium Acetate: Direct Access to 2-Acyl-4-aminoquinazolines . The Journal of Organic Chemistry 86:23, pages 16916-16925.
Crossref
Sumathi Vodnala, Anagani Kanaka Durga Bhavani, Shankaraiah Pagilla, Muralidhar Allam, Nagamani Rayala, Anwita Mudiraj & Phanithi Prakash Babu. (2021) Synthesis and Cytotoxic Studies of Quinazoline-Triazole Hybrid Aza Heterocycles. Russian Journal of General Chemistry 91:11, pages 2304-2310.
Crossref
Ram Karan, Pooja Agarwal, Mukty Sinha & Neelima Mahato. (2021) Recent Advances on Quinazoline Derivatives: A Potential Bioactive Scaffold in Medicinal Chemistry. ChemEngineering 5:4, pages 73.
Crossref
Pennamuthiriyan Anandaraj, Rengan Ramesh & Poomani Kumaradhas. (2021) Palladium( ii ) N , N , O -pincer type complex-mediated dehydrogenative coupling of alcohols to quinazolines . New Journal of Chemistry 45:36, pages 16572-16580.
Crossref
Mohammad Murwih Alidmat, Melati Khairuddean, Naziera Mohammad Norman, Anis Nasihah Mohamed Asri, Mohd Hisyam Mohd Suhaimi & Garima Sharma. (2021) Synthesis, characterization, docking study and biological evaluation of new chalcone, pyrazoline, and pyrimidine derivatives as potent antimalarial compounds. Arabian Journal of Chemistry 14:9, pages 103304.
Crossref
Alexander V. Komkov, Mikhail A. Kozlov, Yurii A. Linitskii, Leonid S. Vasil’ev, Andrey S. Dmitrenok & Igor V. Zavarzin. (2021) Synthesis of new 5-hydroxyquinazoline derivatives from functionalized 5-acetyl-6-methylpyrimidines. Chemistry of Heterocyclic Compounds 57:7-8, pages 772-786.
Crossref
Nisha Abdul Rehuman, Abdullah G. Al‐Sehemi, Della Grace Thomas Parambi, T. M. Rangarajan, Orazio Nicolotti, Hoon Kim & Bijo Mathew. (2021) Current Progress in Quinazoline Derivatives as Acetylcholinesterase and Monoamine Oxidase Inhibitors. ChemistrySelect 6:28, pages 7162-7182.
Crossref
Neeranjini Nallathamby, Chia-Wei Phan, Matej Sova, Luciano Saso & Vikineswary Sabaratnam. (2021) Synthesized 2-Trifluoromethylquinazolines and Quinazolinones Protect BV2 and N2a Cells against LPS- and H2O2-induced Cytotoxicity. Medicinal Chemistry 17:6, pages 623-629.
Crossref
Ke Wang, Hao Chen, Xinyan Dai, Xupeng Huang & Zhiqiang Feng. (2021) Palladium-catalyzed one-pot synthesis of 2-substituted quinazolin-4(3 H )-ones from o -nitrobenzamide and alcohols . RSC Advances 11:22, pages 13119-13123.
Crossref
Joydev K. Laha, Surabhi Panday, Monika Tomar & Ketul V. Patel. (2021) Possible competitive modes of decarboxylation in the annulation reactions of ortho -substituted anilines and arylglyoxylates . Organic & Biomolecular Chemistry 19:4, pages 845-853.
Crossref
Ranju Bansal & Anjleena Malhotra. (2021) Therapeutic progression of quinazolines as targeted chemotherapeutic agents. European Journal of Medicinal Chemistry 211, pages 113016.
Crossref
Mohan Neetha, Thaipparambil Aneeja, C. M. A. Afsina & Gopinathan Anilkumar. (2020) An Overview of Ag‐catalyzed Synthesis of Six‐membered Heterocycles. ChemCatChem 12:21, pages 5330-5358.
Crossref
Natália M. Moreira, Lorena S. R. Martelli, Kiyara I. R. de Julio, Julio Zukerman‐Schpector, Till Opatz & Arlene G. Corrêa. (2020) Copper‐Catalyzed One‐Pot Synthesis of 3‐( N ‐Heteroarenyl)acrylonitriles through Radical Conjugated Addition of β‐Nitrostyrene to Methylazaarenes . European Journal of Organic Chemistry 2020:29, pages 4563-4570.
Crossref
Pradeep S. Jadhavar, Kshitij I. Patel, Tejas M. Dhameliya, Nirjhar Saha, Maulikkumar D. Vaja, Vagolu Siva Krishna, Dharmarajan Sriram & Asit K. Chakraborti. (2020) Benzimidazoquinazolines as new potent anti-TB chemotypes: Design, synthesis, and biological evaluation. Bioorganic Chemistry 99, pages 103774.
Crossref
Satyendra Mishra. 2020. Quinazolinone and Quinazoline Derivatives. Quinazolinone and Quinazoline Derivatives.
Leonid I. Belen’kii, Galina A. Gazieva, Yulia B. Evdokimenkova & Natalya O. Soboleva. 2020. 385 468 .
Alireza Barmak, Khodabakhsh Niknam & Gholamhossein Mohebbi. (2019) Synthesis, Structural Studies, and α-Glucosidase Inhibitory, Antidiabetic, and Antioxidant Activities of 2,3-Dihydroquinazolin-4(1 H )-ones Derived from Pyrazol-4-carbaldehyde and Anilines . ACS Omega 4:19, pages 18087-18099.
Crossref
Nagesh Jatangi & Radha Krishna Palakodety. (2019) Base-catalyzed synthesis of quinazolines in aqueous medium. Tetrahedron Letters 60:44, pages 151186.
Crossref
Wen-Kui Yuan, Sheng-Zheng Sun, Lin-Bao Zhang, Li-Rong Wen & Ming Li. (2019) A concise construction of 4-alkynylquinazolines via [4 + 2] annulation of 4-alkynylbenzoxazinanones with acylhydroxamates under transition-metal-free conditions . Organic Chemistry Frontiers 6:16, pages 2892-2896.
Crossref
Gauravi Yashwantrao, Valmik P. Jejurkar, Rajpratap Kshatriya & Satyajit Saha. (2019) Solvent-Free, Mechanochemically Scalable Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Using Brønsted Acid Catalyst. ACS Sustainable Chemistry & Engineering 7:15, pages 13551-13558.
Crossref
Pandula T. Kirinde Arachchige & Chae S. Yi. (2019) Synthesis of Quinazoline and Quinazolinone Derivatives via Ligand-Promoted Ruthenium-Catalyzed Dehydrogenative and Deaminative Coupling Reaction of 2-Aminophenyl Ketones and 2-Aminobenzamides with Amines. Organic Letters 21:9, pages 3337-3341.
Crossref
Nagesh Jatangi & Radha Krishna Palakodety. (2019) I 2 -Catalyzed oxidative synthesis of N ,4-disubstituted quinazolines and quinazoline oxides . Organic & Biomolecular Chemistry 17:15, pages 3714-3717.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.