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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 50, 2020 - Issue 10
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SYNTHETIC COMMUNICATIONS REVIEWS

Synthesis, in-vitro antibacterial and anticancer screening of novel nicotinonitrile-coumarin hybrids utilizing piperazine citrate

Sherif M. H. SanadChemistry Department, Faculty of Science, Cairo University, Giza, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-0186-6418
ORCID Icon &
Ahmed E. M. MekkyChemistry Department, Faculty of Science, Cairo University, Giza, EgyptORCID Iconhttps://orcid.org/0000-0002-8226-010X
ORCID Icon
Pages 1468-1485 | Received 24 Dec 2019, Published online: 26 Mar 2020

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Abolfazl Olyaei & Mahdieh Sadeghpour. (2023) Recent advances in the synthesis and biological activities of 3-aminoalkyl/3-amidoalkyl-4-hydroxycoumarin derivatives. Synthetic Communications 53:4, pages 275-297.
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Mohamed A. A. Elneairy, Sherif M. H. Sanad & Ahmed E. M. Mekky. (2023) One-pot synthesis and antibacterial screening of new (nicotinonitrile-thiazole)-based mono- and bis(Schiff bases) linked to arene units. Synthetic Communications 53:3, pages 245-261.
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Sherif M. H. Sanad & Ahmed E. M. Mekky. (2022) [3 + 2] Cycloaddition synthesis of new (nicotinonitrile-chromene) hybrids linked to pyrazole units as potential acetylcholinesterase inhibitors. Synthetic Communications 52:16, pages 1672-1684.
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Ahmed M. Abdelfattah, Ahmed E. M. Mekky & Sherif M. H. Sanad. (2022) Synthesis, antibacterial activity and in silico study of new bis(1,3,4-oxadiazoles). Synthetic Communications 52:11-12, pages 1421-1440.
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Nadia Hanafy Metwally, Thoraya Hossam Koraa & Sherif Mohamed Hamed Sanad. (2022) Green one-pot synthesis and in vitro antibacterial screening of pyrano[2,3-c]pyrazoles, 4H-chromenes and pyrazolo[1,5-a]pyrimidines using biocatalyzed pepsin. Synthetic Communications 52:8, pages 1139-1154.
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Ahmed E. M. Mekky, Sherif M. H. Sanad & Tamer T. El-Idreesy. (2021) New thiazole and thiazole-chromene hybrids possessing morpholine units: Piperazine-mediated one-pot synthesis of potential acetylcholinesterase inhibitors. Synthetic Communications 51:21, pages 3332-3344.
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Sherif M. H. Sanad & Ahmed E. M. Mekky. (2021) Efficient synthesis and characterization of novel bis(chromenes) and bis(benzo[f]chromenes) linked to thiazole units. Synthetic Communications 51:4, pages 611-624.
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Ahmed E. M. Mekky, Sherif M. H. Sanad, Ahmed Y. Said & Mohamed A. A. Elneairy. (2020) Synthesis, cytotoxicity, in-vitro antibacterial screening and in-silico study of novel thieno[2,3-b]pyridines as potential pim-1 inhibitors. Synthetic Communications 50:15, pages 2376-2389.
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Articles from other publishers (26)

Jing Wang, Sihui Long, Ziwei Liu, Kadalipura P. Rakesh, Rameshwari Verma, Santosh Kumar Verma & Kothanahally S. Sharath Kumar. (2023) Structure-activity relationship studies of thiazole agents with potential anti methicillin-resistance Staphylococcus aureus (MRSA) activity. Process Biochemistry 132, pages 13-29.
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Sherif M.H. Sanad & Ahmed E.M. Mekky. (2023) New bis(thieno[2,3- b ]pyridine) hybrids linked to arene units as potential bacterial biofilm and MRSA inhibitors . Canadian Journal of Chemistry 101:8, pages 538-547.
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Sherif M. H. Sanad, Ahmed E. M. Mekky & Ahmed A M. Ahmed. (2023) Pyrazolo[5,1‐ b ]quinazolines and Their Bis‐analogues Linked to Different Spacers: Regioselective Synthesis, Antibacterial Screening and SwissADME Prediction Study . ChemistrySelect 8:22.
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Sherif M.H. Sanad & Ahmed E.M. Mekky. (2023) New thieno[2,3-b]pyridine-fused pyrimidin-4(3H)-ones as potential thymidylate synthase inhibitors: Synthesis, SAR, in vitro and in silico study. Journal of Molecular Structure 1282, pages 135236.
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Ceyhun Kucuk, Senay Yurdakul, Namık Özdemir & Belgin Erdem. (2023) Structural and spectroscopic characterization, electronic properties, and biological activity of the 4-(3-methoxyphenyl)piperazin-1-ium 4-(3-methoxyphenyl)piperazine-1-carboxylate monohydrate. Chemical Papers 77:5, pages 2793-2815.
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Wen Lu, Jiongya Tang, Zhenzhen Gu, Lu Sun, Haimeng Wei, Yanqin Wang, Shilong Yang, Xingwei Chi & Li Xu. (2023) Crystal structure, in vitro cytotoxicity, DNA binding and DFT calculations of new copper (II) complexes with coumarin-amide ligand. Journal of Inorganic Biochemistry 238, pages 112030.
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Ahmed E. M. Mekky & Sherif M. H. Sanad. (2022) [3+2] cycloaddition synthesis of new (nicotinonitrile‐chromene)‐based bis(pyrazole) hybrids as potential acetylcholinesterase inhibitors. Journal of Heterocyclic Chemistry 60:1, pages 156-160.
Crossref
Mohamed S. Mohamed Ahmed, Ahmed E.M. Mekky & Sherif M.H. Sanad. (2022) Regioselective [3 + 2] cycloaddition synthesis and theoretical calculations of new chromene-pyrazole hybrids: A DFT-based Parr Function, Fukui Function, local reactivity indexes, and MEP analysis. Journal of Molecular Structure 1267, pages 133583.
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Sherif M. H. Sanad, Ahmed E. M. Mekky & Ahmed A. M. Ahmed. (2022) Tandem synthesis, cytotoxicity, and in silico study of new 1,3,4‐oxadiazoles as potential thymidylate synthase inhibitors. Archiv der Pharmazie 355:10, pages 2200170.
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Ahmed E. M. Mekky, Tamer T. El‐Idreesy & Sherif M. H. Sanad. (2022) Chloramine Trihydrate‐Mediated Tandem Synthesis of New Pyrrole and/or Arene‐Linked Mono‐ and Bis(1,3,4‐Oxadiazole) Hybrids as Potential Bacterial Biofilm and MRSA Inhibitors. Chemistry & Biodiversity 19:8.
Crossref
Ahmed A. M. Ahmed, Ahmed E. M. Mekky & Sherif M. H. Sanad. (2021) Effective synthesis of new benzo-fused macrocyclic and heteromacrocyclic bis(Schiff bases). Journal of the Iranian Chemical Society 19:5, pages 1711-1722.
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Hamzeh Kiyani & Ziba Daroughezadeh. (2022) Efficient and Aqoues Synthesis of 3,4-Disubstituted Isoxazol-5(4H)-one Derivatives Using Piperazine under Green Conditions. HETEROCYCLES 104:9, pages 1625.
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Sherif M.H. Sanad, Ahmed E.M. Mekky & Tamer T. El-Idreesy. (2022) Potential bacterial biofilm, MRSA, and DHFR inhibitors based on new morpholine-linked chromene-thiazole hybrids: One-pot synthesis and in silico study. Journal of Molecular Structure 1248, pages 131476.
Crossref
Sherif M. H. Sanad & Ahmed E. M. Mekky. (2021) 3‐Aminopyrazolo[3,4‐ b ]pyridine: Effective Precursor for Barium Hydroxide‐Mediated Three Components Synthesis of New Mono‐ and Bis(pyrimidines) with Potential Cytotoxic Activity . Chemistry & Biodiversity 19:1.
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Anil Kumar, Varun Dhiman, Pawan Kumar & Deepak Pant. (2021) Effects of piperazine and EDTA in garden snail towards electrolytic variation and antimicrobial activities. Environmental Science and Pollution Research 28:46, pages 65911-65922.
Crossref
Sherif M.H. SanadAhmed E.M. Mekky. (2021) New pyrido[3′,2′:4,5]thieno[3,2- d ]pyrimidin-4(3 H )-one hybrids linked to arene units: synthesis of potential MRSA, VRE, and COX-2 inhibitors . Canadian Journal of Chemistry 99:11, pages 900-909.
Crossref
Sherif M. H. Sanad, Ahmed E. M. Mekky, Ahmed Y. Said & Mohamed A. A. Elneairy. (2021) Pyridine‐2( 1 H )‐thiones: Versatile precursors for one‐pot synthesis of new nicotinonitrile‐thiazole hybrids . Journal of Heterocyclic Chemistry 58:7, pages 1461-1471.
Crossref
Sathish Kumar Konidala, Vijay Kotra, Ravi Chandra Sekhara Reddy Danduga, Phani Kumar Kola, Richie R. Bhandare & Afzal B. Shaik. (2021) Design, multistep synthesis and in-vitro antimicrobial and antioxidant screening of coumarin clubbed chalcone hybrids through molecular hybridization approach. Arabian Journal of Chemistry 14:6, pages 103154.
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Harish C. Upadhyay. (2021) Coumarin-1,2,3-triazole Hybrid Molecules: An Emerging Scaffold for Combating Drug Resistance. Current Topics in Medicinal Chemistry 21:8, pages 737-752.
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Clementina M.M. Santos & Artur M.S. Silva. 2021. 473 532 .
Sherif M. H. Sanad & Ahmed E. M. Mekky. (2020) Novel nicotinonitrile-coumarin hybrids as potential acetylcholinesterase inhibitors: design, synthesis, in vitro and in silico studies. Journal of the Iranian Chemical Society 18:1, pages 213-224.
Crossref
Sherif M. H. Sanad & Ahmed E. M. Mekky. (2020) Synthesis, cytotoxicity and in vitro antibacterial screening of novel hydrazones bearing thienopyridine moiety as potent COX-2 inhibitors. Journal of the Iranian Chemical Society 17:12, pages 3299-3315.
Crossref
Ahmed E. M. Mekky & Sherif M. H. Sanad. (2020) Synthesis and in vitro study of new coumarin derivatives linked to nicotinonitrile moieties as potential acetylcholinesterase inhibitors. Journal of Heterocyclic Chemistry 57:12, pages 4278-4290.
Crossref
Ahmed E.M. Mekky & Sherif M.H. Sanad. (2020) Synthesis and antibacterial evaluation of novel mono- and bis(2H-chromen-2-imine) hybrids linked to heteroarene units. Mendeleev Communications 30:6, pages 762-764.
Crossref
Sherif M. H. Sanad & Ahmed E. M. Mekky. (2020) Piperazine‐mediated tandem synthesis of bis(thieno[2,3‐ b ]pyridines): Versatile precursors for related fused [1,2,4]triazolo[4,3‐ a ]pyrimidines . Journal of Heterocyclic Chemistry 57:8, pages 3142-3152.
Crossref
Sherif M. H. Sanad & Ahmed E. M. Mekky. (2020) Novel Nicotinonitriles and Thieno[2,3‐ b ]pyridines as Potent Biofilm and COX‐2 Inhibitors: Synthesis, In Vitro and In Silico Studies . ChemistrySelect 5:28, pages 8494-8503.
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