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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 50, 2020 - Issue 13
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SYNTHETIC COMMUNICATIONS REVIEWS

Synthesis, characterization, and biological evaluation of new heterocyclic systems 1, 2, 3-triazole-isoxazoline from eugenol by the mixed condensation reactions

Abdelmaoujoud TaiaLaboratory of Molecular Chemistry, Department of Chemistry, Faculty of Sciences Semlalia, University of Cadi Ayyad, Marrakech, Morocco; Correspondence[email protected]
,
Mohamed EssaberLaboratory of Molecular Chemistry, Department of Chemistry, Faculty of Sciences Semlalia, University of Cadi Ayyad, Marrakech, Morocco;
,
Ali OubellaDépartement de Chimie, Faculté des Sciences, Laboratoire de Synthèse Organique et Physico-Chimie Moléculaire, Marrakech, Morocco;
,
Abdeljalil AatifLaboratory of Molecular Chemistry, Department of Chemistry, Faculty of Sciences Semlalia, University of Cadi Ayyad, Marrakech, Morocco;
,
Jacques BodiguelLaboratoire de Chimie Physique Macromoléculaire, UMR CNRS-Université de Lorraine 7375, Nancy Cedex, France;
,
Brigitte Jamart-GrégoireLaboratoire de Chimie Physique Macromoléculaire, UMR CNRS-Université de Lorraine 7375, Nancy Cedex, France;
,
My Youssef Ait IttoDépartement de Chimie, Faculté des Sciences, Laboratoire de Synthèse Organique et Physico-Chimie Moléculaire, Marrakech, Morocco;
&
Hamid MorjaniBioSpectroscopie Translationnelle, BioSpecT - EA7506, UFR de Pharmacie, Université de Reims Champagne-Ardenne, Reims Cedex, France
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Pages 2052-2065 | Received 02 Feb 2020, Published online: 06 May 2020

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Said Byadi, Bimoussa Abdoullah, Mourad Fawzi, Ezaddine Irrou, Younesse Ait Elmachkouri, Ali Oubella, Aziz Auhmani, Hamid Morjani, Mohamed Labd Taha, Anthony Robert, Aziz Aboulmouhajir & Moulay Youssef Ait Itto. (2024) Discovery of a new Bcl-2 inhibitor through synthesis, anticancer activity, docking and MD simulations. Journal of Biomolecular Structure and Dynamics 42:8, pages 4145-4154.
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Abdoullah Bimoussa, Mourad Fawzi, Ali Oubella, Syeda Abida Ejaz, Muhammad Sajjad Bilal, Mohamed Labd Taha, Aziz Auhmani, Hamid Morjani, Anthony Robert, Abdelkhalek Riahi & My Youssef Ait Itto. (2023) Hybrids of thiazolidinone with 1,2,3-triazole derivatives: design, synthesis, biological evaluation, in silico studies, molecular docking, molecular dynamics simulations, and ADMET profiling. Journal of Biomolecular Structure and Dynamics 41:21, pages 11987-11999.
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Ali Oubella, Abdelmaoujoud Taia, Said Byadi, Marouane Ait Lahcen, Abdoullah Bimoussa, Mohamed Essaber, Crtomir Podlipnik, Hamid Morjani, My Youssef Ait Itto & Abdeljalil Aatif. (2023) Chemical profiling, cytotoxic activities through apoptosis induction in human fibrosarcoma and carcinoma cells, and molecular docking of some 1,2,3-triazole-isoxazoline hybrids using the eugenol as a precursors. Journal of Biomolecular Structure and Dynamics 41:7, pages 2759-2771.
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Ali Oubella, Abdoullah Bimoussa, Said Byadi, Yassine Laamari, Mourad Fawzi, Abdellah N’ait ousidi, Domen Oblak, Aziz Auhmani, Abdelkhalek Riahi, Hamid Morjani & My Youssef Ait Itto. (2023) Cytotoxic and apoptotic effects of some (R)-carvone-isoxazoline derivatives on human fibrosarcoma and carcinoma cells: experimental evaluation for cytotoxicity, molecular docking and molecular dynamics studies. Journal of Biomolecular Structure and Dynamics 41:5, pages 1930-1943.
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Mouhi Eddine Hachim, Ali Oubella, Said Byadi, Mourad Fawzi, Yassine Laamari, Lahoucine Bahsis, Aziz Aboulmouhajir, Hamid Morjani, Črtomir Podlipnik, Aziz Auhmani & My Youssef Ait Itto. (2022) Newly synthesized (R)-carvone-derived 1,2,3-triazoles: structural, mechanistic, cytotoxic and molecular docking studies. Journal of Biomolecular Structure and Dynamics 40:16, pages 7205-7217.
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Hong-Yan Guo, Zheng-Ai Chen, Qing-Kun Shen & Zhe-Shan Quan. (2021) Application of triazoles in the structural modification of natural products. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1115-1144.
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Yousef E. Mukhrish, Nasser Jaber Amri, Jehan Y. Al-humaidi, Ali Oubella, Aziz Auhmani & My Youssef Ait Itto. (2024) Discovery of novel thiazolidinone-1,2,3-triazole hybrids with (D)-Limonene skeleton as anticancer agents: Design, synthesis and biological evaluation. Journal of Molecular Structure 1308, pages 138127.
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Juntao Song, Shuai Zhang, Bo Zhang & Junwei Ma. (2023) The anti‐breast cancer therapeutic potential of 1,2,3‐triazole‐containing hybrids. Archiv der Pharmazie 357:3.
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Ipsa Padhy, Paramita Paul, Tripti Sharma, Sabyasachi Banerjee & Arijit Mondal. (2022) Molecular Mechanisms of Action of Eugenol in Cancer: Recent Trends and Advancement. Life 12:11, pages 1795.
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