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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 19, 1989 - Issue 11-12
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Original Articles

A Convenient Synthesis of 3-Behzyl, 3-Benzyl-4-Substituted Coumarins and Their Benzo Derivatives

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Pages 1899-1910 | Received 19 Jan 1989, Published online: 24 Oct 2006

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Read on this site (7)

Lei Yu & Rong Guo. (2011) Recent Advances on the Preparation and Reactivity of Methylenecyclopropanes. Organic Preparations and Procedures International 43:2, pages 209-259.
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D.I. Brahmbhatt, Shashibala Singh & K.C. Patel. (1997) Synthesis, Characterization and Biological Activity of some Poly(Coumarin Methylene)s. International Journal of Polymeric Materials and Polymeric Biomaterials 35:1-4, pages 145-155.
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RaghaoS. Mali, AshokS. Walture & KantipudiN. Babu. (1996) SYNTHESIS OF 7-DESOXY-8-ALLYLCOUMARINS. Organic Preparations and Procedures International 28:2, pages 217-221.
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R.S. Mali & ParamjeetK. Sandhu. (1994) Useful Synthesis of 8-Allyl 5,7-Dimethoxycoumarins. Synthetic Communications 24:20, pages 2883-2891.
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Antigoni Kotali & PhilipA. Harris. (1994) o-HYDROXYARYL KETONES IN ORGANIC SYNTHESIS. A REVIEW. Organic Preparations and Procedures International 26:2, pages 159-192.
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SanjayY. Deshmukh, ShriniwasL. Kelkar & MurzbanS. Wadia. (1990) A One Step General Synthesis of 3-Benzylcoumarins. Synthetic Communications 20:6, pages 855-863.
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Articles from other publishers (25)

Manuel Plaza, Johannes Großkopf, Stefan Breitenlechner, Christoph Bannwarth & Thorsten Bach. (2021) Photochemical Deracemization of Primary Allene Amides by Triplet Energy Transfer: A Combined Synthetic and Theoretical Study. Journal of the American Chemical Society 143:29, pages 11209-11217.
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Jun Xiong, Zhi‐Ying Mu, Gang Yao, Jia‐An Zhang, Qi‐Xun Feng, Hui‐Ting He, Yong‐Long Pang, Hang Shi & Ming‐Wu Ding. (2021) One‐Pot Synthesis of Polysubstituted Pyrroles via Sequential Ketenimine Formation/Ag(I)‐Catalyzed Alkyne Cycloisomerisation Starting from Ylide Adducts . Chinese Journal of Chemistry 39:6, pages 1553-1557.
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U.S. Kanchana, Elizabeth J. Diana, Thomas V. Mathew & Gopinathan Anilkumar. (2020) Palladium‐catalyzed cross‐coupling reactions of coumarin derivatives: An overview. Applied Organometallic Chemistry 34:12.
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V. S. Moskvina & V. P. Khilya. (2019) Recent Progress in the Synthesis of 4-Arylcoumarins. Chemistry of Natural Compounds 55:3, pages 401-427.
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Reuben D. Rieke. 2017. Chemical Synthesis Using Highly Reactive Metals. Chemical Synthesis Using Highly Reactive Metals 13 160 .
Ron Shah & Derek A. Pratt. (2016) Determination of Key Hydrocarbon Autoxidation Products by Fluorescence. The Journal of Organic Chemistry 81:15, pages 6649-6656.
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Ahmadreza Bekhradnia, Elham Domehri & Masome Khosravi. (2016) Novel coumarin-based fluorescent probe for selective detection of Cu(II). Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 152, pages 18-22.
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Fariba Keshavarzipour & Hossein Tavakol. (2015) The synthesis of coumarin derivatives using choline chloride/zinc chloride as a deep eutectic solvent. Journal of the Iranian Chemical Society 13:1, pages 149-153.
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Jie Tang & Lukas J. Gooßen. (2014) Arylalkene Synthesis via Decarboxylative Cross-Coupling of Alkenyl Halides. Organic Letters 16:10, pages 2664-2667.
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Chao Wang, Hao Zhang, Fengrong Xu, Yan Niu, Yun Wu, Xin Wang, Yihong Peng, Jing Sun, Lei Liang & Ping Xu. (2013) Substituted 3-Benzylcoumarins as Allosteric MEK1 Inhibitors: Design, Synthesis and Biological Evaluation as Antiviral Agents. Molecules 18:5, pages 6057-6091.
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Yuansong Jiang, Wanzhi Chen & Weimin Lu. (2012) N-Heterocyclic carbene catalyzed conjugate umpolung reactions leading to coumarin derivatives. RSC Adv. 2:4, pages 1540-1546.
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Young-Bum Kwon, Jin-Hyung Park, Bo-Ram Choi, Hyun-Soo Kim & Cheol-Min Yoon. (2011) Synthesis of 3-Benzylcoumarins Using Suzuki Coupling Reaction. Bulletin of the Korean Chemical Society 32:spc8, pages 2897-2898.
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Reuben D. Rieke & Seung-Hoi Kim. (2011) A novel organozinc reagent 4-coumarinylzinc bromide; preparation and application in the synthesis of 4-substituted coumarin derivatives. Tetrahedron Letters 52:24, pages 3094-3096.
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Angela Stefanachi, Angelo D. Favia, Orazio Nicolotti, Francesco Leonetti, Leonardo Pisani, Marco Catto, Christina Zimmer, Rolf W. Hartmann & Angelo Carotti. (2011) Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Aromatase Inhibitors Selective over 17-α-Hydroxylase/C17−20 Lyase. Journal of Medicinal Chemistry 54:6, pages 1613-1625.
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Maddali L. N. Rao, Varadhachari Venkatesh & Deepak N. Jadhav. (2010) Palladium-Catalyzed Synthesis of 4-Arylcoumarins Using Triarylbismuth Compounds as Atom-Efficient Multicoupling Organometallic Nucleophiles. European Journal of Organic Chemistry 2010:20, pages 3945-3955.
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Yuguang Wang, Bingchun Zhu & Qin Zhu. (2009) Synthesis of 2,4,6-trisubstituted naphthalenes via novel copper-promoted tandem coupling and intramolecular cyclization. Applied Organometallic Chemistry 23:10, pages 398-402.
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Andrea Behrenswerth, Nicole Volz, Jakob Toräng, Sonja Hinz, Stefan Bräse & Christa E. Müller. (2009) Synthesis and pharmacological evaluation of coumarin derivatives as cannabinoid receptor antagonists and inverse agonists. Bioorganic & Medicinal Chemistry 17:7, pages 2842-2851.
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Jakob Toräng, Sylvia Vanderheiden, Martin Nieger & Stefan Bräse. (2007) Synthesis of 3-Alkylcoumarins from Salicylaldehydes and α,β-Unsaturated Aldehydes Utilizing Nucleophilic Carbenes: A New Umpoled Domino Reaction. European Journal of Organic Chemistry 2007:6, pages 943-952.
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Jie Wu & Zhen Yang. (2001) Nickel-Catalyzed Cross-Couplings of 4-Diethylphosphonooxycoumarins with Organozinc Reagents:  An Efficient New Methodology for the Synthesis of 4-Substituted Coumarins. The Journal of Organic Chemistry 66:23, pages 7875-7878.
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Yuan Liao & Binghe Wang. (1999) Substituted coumarins as esterase-sensitive prodrug moieties with improved release rates. Bioorganic & Medicinal Chemistry Letters 9:13, pages 1795-1800.
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Bernd Peschke, Michael Ankersen, Birgit Sehested Hansen, Thomas Kruse Hansen, Nils Langeland Johansen, Jesper Lau, Kjeld Madsen, Hans Petersen, Henning Thøgersen & Brett Watson. (1999) Synthesis and in vitro characterization of new growth hormone secretagogues derived from ipamorelin with dipeptidomimetic N-terminals. European Journal of Medicinal Chemistry 34:5, pages 363-380.
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D.I. Brahmbhatt, Shashibala Singh & K.C. Patel. (1999) Synthesis, characterization and biological activity of some poly(coumarin ethylene)s. European Polymer Journal 35:2, pages 317-324.
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Demetrios N. Nicolaides, Konstantinos E. Litinas, Demetrios A. Lefkaditis, Spyros G. Adamopoulos, C. P. Raptopoulou & Aris Terzis. (1994) Reactions of α-alkyl- or α-halogeno-alkoxycarbonylmethylene(triphenyl)phosphoranes with phenanthrene-9, 10-quinone. Synthesis of phenanthro[9, 10-b]furan derivatives. J. Chem. Soc., Perkin Trans. 1:15, pages 2107-2112.
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D. N. Nicolaides, K. C. Fylaktakidou, C. Bezergiannidou‐Balouktsi & K. E. Litinas. (2009) Reactions of 4,6‐bis(acetyl)resorcinol with alkoxycarbonylalkylidene(triphenyl)phosphoranes. Preparation of coumarin derivatives. Journal of Heterocyclic Chemistry 31:1, pages 173-176.
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N. BRITTO, V. G. GORE, R. S. MALI & A. C. RANADE. (2016) ChemInform Abstract: A Convenient Synthesis of 3‐Benzyl, 3‐Benzyl‐4‐Substituted Coumarins, and Their Benzo Derivatives.. ChemInform 21:12.
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