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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 22, 1992 - Issue 8
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Original Articles

Synthesis of Oxadeazaflavines from Barbituric Acid and Aromatic Aldehydes

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Pages 1159-1164 | Received 14 Nov 1991, Published online: 23 Sep 2006

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Ji‐Tai Li, Hong‐Guang Dai, Da Liu & Tong‐Shuang Li. (2006) Efficient Method for Synthesis of the Derivatives of 5‐Arylidene Barbituric Acid Catalyzed by Aminosulfonic Acid With Grinding. Synthetic Communications 36:6, pages 789-794.
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Yi Hu, Zhen‐Chu Chen, Zhang‐Gao Le & Qin‐Guo Zheng. (2004) Organic Reactions in Ionic Liquids: Ionic Liquid Promoted Knoevenagel Condensation of Aromatic Aldehydes with (2‐Thio)Barbituric Acid. Synthetic Communications 34:24, pages 4521-4529.
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Guadalupe Alcerreca, Rubén Sanabria, René Miranda, Gabriel Arroyo, Joaquín Tamariz & Francisco Delgado. (2000) Preparation of Benzylidene Barbituric Acids Promoted by Infrared Irradiation in Absence of Solvent. Synthetic Communications 30:7, pages 1295-1301.
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Articles from other publishers (29)

Manuel K. Langer, Ataur Rahman, Hymonti Dey, Trude Anderssen, Francesco Zilioli, Tor Haug, Hans-Matti Blencke, Klara Stensvåg, Morten B. Strøm & Annette Bayer. (2022) A concise SAR-analysis of antimicrobial cationic amphipathic barbiturates for an improved activity-toxicity profile. European Journal of Medicinal Chemistry 241, pages 114632.
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Mahdieh Yahyazadehfar, Enayatollah Sheikhhosseini, Sayed Ali Ahmadi & Dadkhoda Ghazanfari. (2022) Microwave-assisted synthetic method of novel Bi2O3 nanostructure and its application as a high-performance nano-catalyst in preparing benzylidene barbituric acid derivatives. Frontiers in Chemistry 10.
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Rupali Vaid, Neha Sharma, Monika Gupta & Bushra Chowhan. (2022) Nanosized calcined mixed oxides-supported alkali metal (K2O/Al2O3–CaO) as solid base catalyst: preparation and investigation of its catalytic efficiency in the synthesis of benzylidene malononitriles/barbiturates and in pyrano[2,3-d]pyrimidines. Journal of the Iranian Chemical Society 19:7, pages 2855-2870.
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Yi Zhou, He-Jia Xü, Xue-Jiao Li, Cheng-Wei Lü & Yue An. (2021) Synthesis and mechanism study of two similar colorimetric fluorescent probes for specific detection of bisulfite and hypochlorite. Research on Chemical Intermediates 48:1, pages 85-100.
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Shila Darvishzad, Nader Daneshvar, Farhad Shirini & Hassan Tajik. (2021) Knoevenagel condensation in aqueous media promoted by 2,2′-bipyridinium dihydrogen phosphate as a green efficient catalyst. Research on Chemical Intermediates 47:7, pages 2973-2984.
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Ahmed El-Mekabaty, Hassan A. Etman, Ahmed Mosbah & Ahmed A. Fadda. (2020) Reactivity of Barbituric, Thiobarbituric Acids and Their Related Analogues: Synthesis of Substituted and Heterocycles-based Pyrimidines. Current Organic Chemistry 24:14, pages 1610-1642.
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Niloufar Safari, Farhad Shirini & Hassan Tajik. (2018) Verjuice as a green and bio-degradable solvent/catalyst for facile and eco-friendly synthesis of 5-arylmethylenepyrimidine-2,4,6-trione, pyrano[2,3-d]pyrimidinone and pyrimido[4,5-d]pyrimidinone derivatives. Journal of the Iranian Chemical Society 16:4, pages 887-897.
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Shila Darvishzad, Nader Daneshvar, Farhad Shirini & Hassan Tajik. (2019) Introduction of piperazine-1,4-diium dihydrogen phosphate as a new and highly efficient dicationic brönsted acidic ionic salt for the synthesis of (thio)barbituric acid derivatives in water. Journal of Molecular Structure 1178, pages 420-427.
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Nader Daneshvar, Mitra Nasiri, Maryam Shirzad, Mohaddeseh Safarpoor Nikoo Langarudi, Farhad Shirini & Hassan Tajik. (2018) The introduction of two new imidazole-based bis-dicationic Brönsted acidic ionic liquids and comparison of their catalytic activity in the synthesis of barbituric acid derivatives. New Journal of Chemistry 42:12, pages 9744-9756.
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Masoumeh Abedini, Farhad Shirini, Javad Mohammad-Alinejad Omran, Mohadeseh Seddighi & Omid Goli-Jolodar. (2015) Succinimidinium N-sulfonic acid hydrogen sulfate as an efficient ionic liquid catalyst for the synthesis of 5-arylmethylene-pyrimidine-2,4,6-trione and pyrano[2,3-d]pyrimidinone derivatives. Research on Chemical Intermediates 42:5, pages 4443-4458.
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Narges Seyyedi, Farhad Shirini & Mohaddeseh Safarpoor Nikoo Langarudi. (2016) DABCO-based ionic liquids: green and recyclable catalysts for the synthesis of barbituric and thiobarbituric acid derivatives in aqueous media. RSC Advances 6:50, pages 44630-44640.
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Wei Shi, Shiyu Zhao, Yue Su, Yonghai Hui & Zhengfeng Xie. (2016) Barbituric acid–triphenylamine adduct as an AIEE-type molecule and optical probe for mercury( ii ) . New Journal of Chemistry 40:9, pages 7814-7820.
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Farhad Shirini, Mohaddeseh Safarpoor Nikoo Langarudi, Mohadeseh Seddighi & Omid Goli Jolodar. (2015) Bi-SO3H functionalized ionic liquid based on DABCO as a mild and efficient catalyst for the synthesis of 1,8-dioxo-octahydro-xanthene and 5-arylmethylene-pyrimidine-2,4,6-trione derivatives. Research on Chemical Intermediates 41:11, pages 8483-8497.
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Sneha, Jitender M. Khurana, Chetan Sharma & K. R. Aneja. (2014) Chemoselective N-benzylation of 2-thiohydantoins and 2-thiobarbituric acids catalyzed by PEG-stabilized Ni nanoparticles and their anti-microbial activities. Medicinal Chemistry Research 23:10, pages 4595-4606.
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Song Liu, Yu Lei, Zhen Yang & Yu Lan. (2014) Theoretical study of the electron-donating effects of thiourea ligands in catalysis. Journal of Molecular Structure 1074, pages 527-533.
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Franco King-Chi Leung, Jian-Fang Cui, Tsz-Wai Hui, Zhong-Yuan Zhou & Man-Kin Wong. (2014) Hydrogen bond donor–acceptor–donor organocatalysis for conjugate addition of benzylidene barbiturates via complementary DAD–ADA hydrogen bonding. RSC Adv. 4:51, pages 26748-26756.
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Jaspreet Kaur Rajput & Gagandeep Kaur. (2013) CoFe2O4 nanoparticles: An efficient heterogeneous magnetically separable catalyst for “click” synthesis of arylidene barbituric acid derivatives at room temperature. Chinese Journal of Catalysis 34:9, pages 1697-1704.
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J. Daniel Figueroa-Villar & Andreia A. Vieira. (2013) Nuclear magnetic resonance and molecular modeling study of exocyclic carbon–carbon double bond polarization in benzylidene barbiturates. Journal of Molecular Structure 1034, pages 310-317.
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Namrata Dixit, R.K. Koiri, B.K. Maurya, S.K. Trigun, Claudia Höbartner & Lallan Mishra. (2011) One pot synthesis of Cu(II) 2,2′-bipyridyl complexes of 5-hydroxy-hydurilic acid and alloxanic acid: Synthesis, crystal structure, chemical nuclease activity and cytotoxicity. Journal of Inorganic Biochemistry 105:2, pages 256-267.
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Enayatollah Sheikhhosseini, Mohammad A. Bigdeli, Azizollah Habibi & Saeed Balalaie. (2011) An Experimental Study of Special Leaving Group Behavior in the Reaction of Arylidenebarbituric Acids with Carbon Nucleophiles. HETEROCYCLES 83:1, pages 107.
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Jitender M. Khurana & Kanika Vij. (2010) Nickel Nanoparticles Catalyzed Knoevenagel Condensation of Aromatic Aldehydes with Barbituric Acids and 2-Thiobarbituric Acids. Catalysis Letters 138:1-2, pages 104-110.
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N. Dixit, K. Goto, L. Mishra & H.W. Roesky. (2010) Supramolecular architectures constructed with the skeletons of zinc(II) 2,2′-bipyridine and barbiturate anion: Synthesis and characterization. Polyhedron 29:4, pages 1299-1304.
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Namrata Dixit, P. K. Shukla, P. C. Mishra, Lallan Mishra & Herbert W. Roesky. (2009) Binding of Urea and Thiourea with a Barbiturate Derivative: Experimental and Theoretical Approach. The Journal of Physical Chemistry A 114:1, pages 97-104.
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Ji-Tai Li & Ming-Xuan Sun. (2009) SiO2·12WO3·24H2O: a Highly Efficient Catalyst for the Synthesis of 5-Arylidene Barbituric Acid in the Presence of Water. Australian Journal of Chemistry 62:4, pages 353.
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Cherkupally Sanjeeva Reddy & Adki Nagaraj. (2007) Knoevenagel condensation of α,β-unsaturated aromatic aldehydes with barbituric acid under non-catalytic and solvent-free conditions. Chinese Chemical Letters 18:12, pages 1431-1435.
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. 1996. Synthetic and Natural Phenols. Synthetic and Natural Phenols 191 224 .
José Daniel Figueroa-Villar & Elizabete R. Cruz. (1993) A simple approach towards the synthesis of oxadeazaflavines. Tetrahedron 49:14, pages 2855-2862.
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J. D. FIGUEROA‐VILLAR, E. R. CRUZ & N. L. DOS SANTOS. (2010) ChemInform Abstract: Synthesis of Oxadeazaflavins from Barbituric Acid and Aromatic Aldehydes.. ChemInform 23:38.
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Annette Bayer, Manuel K. Langer, Ataur Rahman, Hymonti Dey, Trude Anderssen, Francesco Zilioli, Tor Haug, Hans-Matti Blencke, Klara Stensvåg & Morten B. Strøm. (2022) A Concise Sar-Analysis of Antimicrobial Cationic Amphipathic Barbiturates for an Improved Activity-Toxicity Profile. SSRN Electronic Journal.
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