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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 22, 1992 - Issue 20
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Original Articles

A Convenient Synthesis of 2-Butyl-4(5)-chloro-1H-imidazole-5(4)-carboxaldehyde

Stephen P. Watson Glaxo Group Research, Park Road, Ware, Hertfordshire, SG12 ODJ, U.K.
Pages 2971-2977 | Received 05 Jun 1992, Published online: 23 Sep 2006

Citations (14)

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Guncheol Kim, Sunwha Kang, Youngha Ryu, Gyochang Keum & Myung Joon Seo. (1999) A Pd-Catalyzed Double Coupling Reaction to 4,5-Disubstituted Imidazole Alkynes. Synthetic Communications 29:3, pages 507-512.
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Yao-Jun Shi, LisaF. Frey, DavidM. Tschaen & ThomasR. Verhoeven. (1993) A Practical Synthesis of 2-Butyl-4(5)-chloro-5(4)-hydroxymethyl- 1H-imidazole. Synthetic Communications 23:18, pages 2623-2630.
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Articles from other publishers (12)

Renzo Rossi & Maurizio Ciofalo. (2020) An Updated Review on the Synthesis and Antibacterial Activity of Molecular Hybrids and Conjugates Bearing Imidazole Moiety. Molecules 25:21, pages 5133.
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Ruben Vardanyan & Victor Hruby. 2016. Synthesis of Best-Seller Drugs. Synthesis of Best-Seller Drugs 329 356 .
V. A. Chornous, M. K. Bratenko & M. V. Vovk. (2009) Polyfunctional imidazoles: I. Synthesis of 1-substituted 4-chloro-1H-imidazole-5-carbaldehydes by Vilsmeier-Haack reaction. Russian Journal of Organic Chemistry 45:8, pages 1210-1213.
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John E Tellew, Rose Ann F Baska, Sophie M Beyer, Kenneth E Carlson, Lyndon A Cornelius, Leena Fadnis, Zhengxiang Gu, Bridgette L Kunst, Mark C Kowala, Hossain Monshizadegan, Natesan Murugesan, Carol S Ryan, Maria T Valentine, Yifan Yang & John E Macor. (2003) Discovery of 4′-[(Imidazol-1-yl)methyl]biphenyl-2-sulfonamides as dual endothelin/Angiotensin II receptor antagonists. Bioorganic & Medicinal Chemistry Letters 13:6, pages 1093-1096.
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Peter E. Maligres, Marjorie S. Waters, Steven A. Weissman, J. Christopher McWilliams, Stephanie Lewis, Jennifer Cowen, Robert A. Reamer, R. P. Volante, Paul J. Reider & David Askin. (2009) Preparation of a clinically investigated ras farnesyl transferase inhibitor. Journal of Heterocyclic Chemistry 40:2, pages 229-241.
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A. Shafiee, J. Shahbazi Mojarrad, M. A. Jalili, H. R. Adhami & F. Hadizadeh. (2009) Syntheses of substituted pyrrolo[2,3‐ d ]imidazole‐5‐carboxylates and substitued pyrrolo[3,2‐ d ]imidazole‐5‐carboxylates . Journal of Heterocyclic Chemistry 39:2, pages 367-373.
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Susan C. Shilcrat, Mohamed K. Mokhallalati, Joseph M. D. Fortunak & Lendon N. Pridgen. (1997) A New Regioselective Synthesis of 1,2,5-Trisubstituted 1 H -Imidazoles and Its Application to the Development of Eprosartan . The Journal of Organic Chemistry 62:24, pages 8449-8454.
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M.Ross Grimmett. 1997. Imidazole and Benzimidazole Synthesis. Imidazole and Benzimidazole Synthesis 227 248 .
. 1996. Comprehensive Heterocyclic Chemistry II. Comprehensive Heterocyclic Chemistry II 817 932 .
M. Ross Grimmett. 1996. Comprehensive Heterocyclic Chemistry II. Comprehensive Heterocyclic Chemistry II 77 220 .
G I Koldobskii & Vladimir A Ostrovskii. (1994) Tetrazoles. Russian Chemical Reviews 63:10, pages 797-814.
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S. P. WATSON. (2010) ChemInform Abstract: A Convenient Synthesis of 2‐Butyl‐4(5)‐chloro‐1H‐imidazole‐5(4)‐ carboxaldehyde.. ChemInform 24:17.
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