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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 25, 1995 - Issue 12
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Original Articles

An Efficient Synthesis of (±)-4-Amino-3-(4-chlorophenyl)-butyric Acid. (Baclofen)

Toshiro Ibuka Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto, 606, Japan
,
An[ggrave]ele Schoenfelder Laboratoire de Pharmacochimie Moléculaire (UPR 421), Centre de Neurochimie, 5, rue Blaise Pascal, 67084, Strasbourg, France
,
Patricia Bildstein Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto, 606, Japan
&
Andre Mann Laboratoire de Pharmacochimie Moléculaire (UPR 421), Centre de Neurochimie, 5, rue Blaise Pascal, 67084, Strasbourg, France
Pages 1777-1782 | Received 27 Oct 1994, Published online: 23 Sep 2006

Citations (15)

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Ravi Varala & Srinivas R. Adapa. (2006) Novel Approach to the Synthesis of (R,S)‐Baclofen via PD(II)‐Bipyridine–Catalyzed Conjugative Addition. Synthetic Communications 36:24, pages 3743-3747.
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Fernando Coelho, MariangelaB. M. de Azevedo, Roberta Boschiero & Patrícia Resende. (1997) A Simple and Efficient New Approach to the Total Synthesis of (±)-4-Amino-3-(4-Chlorophenyl)-Butyric Acid (BACLOFEN). Synthetic Communications 27:14, pages 2455-2465.
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Articles from other publishers (13)

Changdev Raut, Shafiya Kausar Qureshi, Nitin Kadam, Kailas Mungase, Nagaraju Marepu, Ashutosh Jagtap & Narendra Ambhaikar. (2023) Novel Synthetic Industrial Approach for Efficient Synthesis of Baclofen through C–C Bond Formation. Synlett.
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Shuai Liu, Sen-Lin Wang, Jie Wan, Shuang Peng, Jie-Rui Zhang, Hua-Jiao Ding, Bin Zhang, Hai-Liang Ni, Peng Cao, Ping Hu, Bi-Qin Wang & Bin Chen. (2023) Nickel-Catalyzed Reductive Cross-Coupling of Aziridines and Allylic Chlorides. Organic Letters 25:35, pages 6582-6586.
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Yu Li, Guo-Cui Ji, Chen Chao, Siwei Bi & Yuan-Ye Jiang. (2023) Computation Study on Copper-Catalyzed Aerobic Intramolecular Aminooxygenative C═C Bond Cleavage to Imides: Different Roles of Mononuclear and Dinuclear Copper Complexes. ACS Catalysis, pages 3815-3829.
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Saeed Kakaei & Elham Sattarzadeh Khameneh. (2018) An efficient and simple ultrasound-assisted approach to synthesis of Baclofen. Main Group Chemistry 17:2, pages 161-164.
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Tomasz Wdowik & Sherry R. Chemler. (2017) Direct Synthesis of 2-Formylpyrrolidines, 2-Pyrrolidinones and 2-Dihydrofuranones via Aerobic Copper-Catalyzed Aminooxygenation and Dioxygenation of 4-Pentenylsulfonamides and 4-Pentenylalcohols. Journal of the American Chemical Society 139:28, pages 9515-9518.
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Kallolmay Biswas, Rajesh Gholap, Padakanti Srinivas, Sachin Kanyal & Koushik Das Sarma. (2014) β-Substituted γ-butyrolactams from mucochloric acid: synthesis of (±)-baclofen and other γ-aminobutyric acids and useful building blocks. RSC Advances 4:5, pages 2538-2545.
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Kunio Ogasawara & Masato Hayashi. (2003) A Diastereocontrolled Route to (R)-(-)- Baclofen Using a Cyclopentanoid Chiral Building Block. HETEROCYCLES 59:2, pages 785.
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Albertina G. Moglioni, Beatriz N. Brousse, Angel Álvarez-Larena, Graciela Y. Moltrasio & Rosa M. Ortuño. (2002) Stereoselective synthesis of cyclobutyl GABA analogues and related compounds from (−)-(S)-verbenone. Tetrahedron: Asymmetry 13:5, pages 451-454.
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Kuriya Madavu, Lokanatha Rai & Alfred Hassner. 2000. Advances in Strained and Interesting Organic Molecules Volume 8. Advances in Strained and Interesting Organic Molecules Volume 8 187 257 .
Ioana Ungureanu, Cristian Bologa, Saïd Chayer & André Mann. (1999) Phenylaziridine as a 1,3-dipole. Application to the synthesis of functionalized pyrrolidines. Tetrahedron Letters 40:29, pages 5315-5318.
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Claudio Mazzini, Jacques Lebreton, Véronique Alphand & Roland Furstoss. (1997) A chemoenzymatic strategy for the synthesis of enantiopure (R)-(−)-baclofen. Tetrahedron Letters 38:7, pages 1195-1196.
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Marie-Reine Schneider, André Mann & Maurizio Taddei. (1996) Ring opening of phenylaziridines with allylsilanes. Tetrahedron Letters 37:47, pages 8493-8496.
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T. IBUKA, A. SCHOENFELDER, P. BILDSTEIN & A. MANN. (2010) ChemInform Abstract: Efficient Synthesis of (.+‐.)‐4‐Amino‐3‐(4‐chlorophenyl)butyric Acid. ( Baclofen).. ChemInform 26:36.
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