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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 26, 1996 - Issue 8
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Original Articles

Efficient Synthesis of (S)-4(5)-[1-(2,3-Dimethylphenyl) ethyl]imidazole tartrate, the Potent α2 Adrenoceptor Agonist Dexmedetomidine

Alex A. Cordi Institut de Recherches Servier, 11 rue des Moulineaux, 92150, Suresnes, France
,
Thierry Persigand Institut de Recherches Servier, 11 rue des Moulineaux, 92150, Suresnes, France
&
Jean-Pierre Lecouvé ORIL, 13 rue Auguste Desgenetais, BP 17, 76210, Bolbec, France
Pages 1585-1593 | Received 30 Sep 1995, Published online: 15 Aug 2006

Citations (14)

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H. Fakhraian, H. Toulabi, E. Choobdari, M. H. Peyrovi & H. Hadj Ghanbary. (2015) Synthesis and Enantiomeric Resolution of Medetomidine. Organic Preparations and Procedures International 47:2, pages 141-148.
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Articles from other publishers (13)

Dmitry Orekhov. (2024) Research and Development on the Manufacturing Process of Dexmedetomidine from Chiral Precursors: Resolution–Racemization–Recycle Synthesis Strategy. Organic Process Research & Development 28:4, pages 1032-1054.
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Nidhi Rani, Randhir Singh & Praveen Kumar. (2023) Imidazole and Derivatives Drugs Synthesis: A Review. Current Organic Synthesis 20:6, pages 630-662.
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Babak Kaboudin, Hamideh Haghighat, Samira Aieni, Leila Behrouzi, Foad Kazemi, Jun-ya Kato, Hiroshi Aoyama & Tsutomu Yokomatsu. (2017) A novel and facile route for the synthesis of medetomidine as the ?2-adrenoceptor agonist. Journal of the Iranian Chemical Society 14:8, pages 1735-1739.
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Pramod B. Pansuriya, Glenn E. M. Maguire & Holger B. Friedrich. (2015) Physicochemical characterization and decomposition kinetics of (S)-4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole HCl/S-enantiomer of medetomidineHCl. Journal of Thermal Analysis and Calorimetry 124:1, pages 269-278.
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Ebrahim Choobdari, Hossein Fakhraian & Mohammad Hassan Peyrovi. (2014) Anion Effect on the Binary and Ternary Phase Diagrams of Chiral Medetomidine Salts and Conglomerate Crystal Formation. Chirality 26:3, pages 183-188.
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Ebrahim Choobdari, Hossein Fakhraian & Mohammad Hassan Peyrovi. (2013) Prediction and experimental determination of the binary and ternary phase diagrams of (±)medetomidine hydrochloride. Tetrahedron: Asymmetry 24:13-14, pages 801-806.
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Liubov Shtykova, Camilla Fant, Paul Handa, Ann Larsson, Kent Berntsson, Hans Blanck, Roger Simonsson, Magnus Nydén & Hanna Ingelsten Härelind. (2009) Adsorption of antifouling booster biocides on metal oxide nanoparticles: Effect of different metal oxides and solvents. Progress in Organic Coatings 64:1, pages 20-26.
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Jun-ichi Kawakami, Kazuhiro Kimura & Masayoshi Yamaoka. (2007) A Concise Synthesis of Racemic 1-(6,7-Dimethoxy-2-naphthyl)-1-(1 H -imidazol-4-yl)-2-methylpropan-1-ol for a Potent C 17 , 20 -Lyase Inhibitor . Organic Process Research & Development 11:2, pages 206-209.
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Paul Handa, Camilla Fant & Magnus Nydén. (2006) Antifouling agent release from marine coatings-ion pair formation/dissolution for controlled release. Progress in Organic Coatings 57:4, pages 376-382.
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Camilla Fant, Paul Handa & Magnus Nydén. (2006) Complexation Chemistry for Tuning Release from Polymer Coatings. The Journal of Physical Chemistry B 110:43, pages 21808-21815.
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Liubov S. Shtykova, Denis Ostrovskii, Paul Handa, Krister Holmberg & Magnus Nydén. (2004) NMR diffusometry and FTIR in the study of the interaction between antifouling agent and binder in marine paints. Progress in Organic Coatings 51:2, pages 125-133.
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Michael A. Walters & J. Ramón Vargas. 1997. 148 169 .
A. A. CORDI, T. PERSIGAND & J.‐P. LECOUVE. (2010) ChemInform Abstract: Efficient Synthesis of (S)‐4(5)‐(1‐(2,3‐Dimethylphenyl)ethyl)imidazole Tartrate, the Potent α2 Adrenoceptor Agonist Dexmedetomidine.. ChemInform 27:32.
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