Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 26, 1996 - Issue 2
315
Views
48
CrossRef citations to date
0
Altmetric
Original Articles

A Novel Asymmetric Total Synthesis of (+)-Artemisinin

, , &
Pages 321-329 | Received 05 Jul 1995, Published online: 21 Aug 2006

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Zhonglei Wang, Liyan Yang, Xiuwei Yang & Xiaohua Zhang. (2014) Advances in the Chemical Synthesis of Artemisinin. Synthetic Communications 44:14, pages 1987-2003.
Read now

Articles from other publishers (47)

M. Lancel, B. Tambosco & Z. Amara. 2023. Photochemistry. Photochemistry 301 330 .
Grazia Luisi. 2023. Terpenes. Terpenes 158 227 .
Majid M. Heravi, Batoul Alipour, Vahideh Zadsirjan & Masoume Malmir. (2023) Robinson Annulation Applied to the Total Synthesis of Natural Products. Asian Journal of Organic Chemistry 12:3.
Crossref
Yankai Dong, Lina Liu, Jie Han, Lianqing Zhang, Yi Wang, Juan Li, Yuexiang Li, He Liu, Kun Zhou, Luyao Li, Xin Wang, Xue Shen, Meiling Zhang, Bo Zhang & Xiaofei Hu. (2022) Worldwide Research Trends on Artemisinin: A Bibliometric Analysis From 2000 to 2021. Frontiers in Medicine 9.
Crossref
Gen Li, Mingliang Lou & Xiangbing Qi. (2022) A brief overview of classical natural product drug synthesis and bioactivity. Organic Chemistry Frontiers 9:2, pages 517-571.
Crossref
Tam Minh Le & Zsolt Szakonyi. (2021) Enantiomeric Isopulegol as the Chiral Pool in the Total Synthesis of Bioactive Agents. The Chemical Record 22:1.
Crossref
Karunakar Reddy Bonepally, Norihito Takahashi, Naoya Matsuoka, Hikari Koi, Haruki Mizoguchi, Takahisa Hiruma, Kyohei Ochiai, Shun Suzuki, Yutaka Yamagishi, Hideaki Oikawa, Aki Ishiyama, Rei Hokari, Masato Iwatsuki, Kazuhiko Otoguro, Satoshi O̅mura, Nobutaka Kato & Hiroki Oguri. (2020) Rapid and Systematic Exploration of Chemical Space Relevant to Artemisinins: Anti-malarial Activities of Skeletally Diversified Tetracyclic Peroxides and 6-Aza-artemisinins. The Journal of Organic Chemistry 85:15, pages 9694-9712.
Crossref
Elena Horosanskaia, Susann Triemer, Andreas Seidel-Morgenstern & Heike Lorenz. (2019) Purification of Artemisinin from the Product Solution of a Semisynthetic Reaction within a Single Crystallization Step. Organic Process Research & Development 23:9, pages 2074-2079.
Crossref
Lucas A. Morrill, Robert B. Susick, Jason V. Chari & Neil K. Garg. (2019) Total Synthesis as a Vehicle for Collaboration. Journal of the American Chemical Society 141:32, pages 12423-12443.
Crossref
Karunakar Reddy Bonepally, Takahisa Hiruma, Haruki Mizoguchi, Kyohei Ochiai, Shun Suzuki, Hideaki Oikawa, Aki Ishiyama, Rei Hokari, Masato Iwatsuki, Kazuhiko Otoguro, Satoshi O̅mura & Hiroki Oguri. (2018) Design and De Novo Synthesis of 6-Aza-artemisinins . Organic Letters 20:15, pages 4667-4671.
Crossref
Xirui Hu, Pharath Lim, Rick M. Fairhurst & Thomas J. Maimone. (2018) Synthesis and study of the antimalarial cardamom peroxide. Tetrahedron 74:26, pages 3358-3369.
Crossref
Vera Vil’, Ivan Yaremenko, Alexey Ilovaisky & Alexander Terent’ev. (2017) Synthetic Strategies for Peroxide Ring Construction in Artemisinin. Molecules 22:1, pages 117.
Crossref
René Csuk, Anja Barthel-Niesen, Dieter Ströhl, Ralph Kluge, Christoph Wagner & Ahmed Al-Harrasi. (2015) Oxidative and reductive transformations of 11-keto-β-boswellic acid. Tetrahedron 71:13, pages 2025-2034.
Crossref
Michael A. Corsello & Neil K. Garg. (2015) Synthetic chemistry fuels interdisciplinary approaches to the production of artemisinin. Natural Product Reports 32:3, pages 359-366.
Crossref
Timothy J. Brocksom, Kleber T. de Oliveira, Marco A. B. Ferreira & Bruno M. Servilha. 2015. Bioactive Essential Oils and Cancer. Bioactive Essential Oils and Cancer 81 109 .
Bernd Schäfer. (2014) Artemisinin. Chemie in unserer Zeit 48:3, pages 216-225.
Crossref
Kexuan Tang, Qian Shen, Tingxiang Yan & Xueqing Fu. (2014) Transgenic approach to increase artemisinin content in Artemisia annua L.. Plant Cell Reports 33:4, pages 605-615.
Crossref
Joël Turconi, Frédéric Griolet, Ronan Guevel, Gilles Oddon, Roberto Villa, Andrea Geatti, Massimo Hvala, Kai Rossen, Rudolf Göller & Andreas Burgard. (2014) Semisynthetic Artemisinin, the Chemical Path to Industrial Production. Organic Process Research & Development 18:3, pages 417-422.
Crossref
Christian A. Kuttruff, Martin D. Eastgate & Phil S. Baran. (2014) Natural product synthesis in the age of scalability. Nat. Prod. Rep. 31:4, pages 419-432.
Crossref
Sachin Malik, Suroor A. Khan, Priya Ahuja, Satish K. Arya, Shikha Sahu & Kapendra Sahu. (2013) Singlet oxygen-mediated synthesis of malarial chemotherapeutic agents. Medicinal Chemistry Research 22:12, pages 5633-5653.
Crossref
Hong‐Dong Hao, Sergio Wittlin & Yikang Wu. (2013) Potent Antimalarial 1,2,4‐Trioxanes through Perhydrolysis of Epoxides. Chemistry – A European Journal 19:23, pages 7605-7619.
Crossref
Hui-Jun Chen, Wei-Bo Han, Hong-Dong Hao & Yikang Wu. (2013) A facile and scalable synthesis of qinghaosu (artemisinin). Tetrahedron 69:3, pages 1112-1114.
Crossref
Chunyin Zhu & Silas P. Cook. (2012) A Concise Synthesis of (+)-Artemisinin. Journal of the American Chemical Society 134:33, pages 13577-13579.
Crossref
Weiwei Mao, Yu Zhang & Ao Zhang. 2012. Case Studies in Modern Drug Discovery and Development. Case Studies in Modern Drug Discovery and Development 227 256 .
François Lévesque & Peter H. Seeberger. (2012) Continuous‐Flow Synthesis of the Anti‐Malaria Drug Artemisinin. Angewandte Chemie International Edition 51:7, pages 1706-1709.
Crossref
François Lévesque & Peter H. Seeberger. (2012) Kontinuierliche Synthese des Malariawirkstoffs Artemisinin. Angewandte Chemie 124:7, pages 1738-1741.
Crossref
Hong-Dong Hao, Yun Li, Wei-Bo Han & Yikang Wu. (2011) A Hydrogen Peroxide Based Access to Qinghaosu (Artemisinin). Organic Letters 13:16, pages 4212-4215.
Crossref
Alex M. Szpilman & Erick M. Carreira. (2010) Probing the Biology of Natural Products: Molecular Editing by Diverted Total Synthesis. Angewandte Chemie International Edition 49:50, pages 9592-9628.
Crossref
Alex M. Szpilman & Erick M. Carreira. (2010) Untersuchung der Biologie von Naturstoffen: systematische Strukturvariation durch umgelenkte Totalsynthese. Angewandte Chemie 122:50, pages 9786-9823.
Crossref
J.S. Yadav, B. Thirupathaiah & P. Srihari. (2010) A concise stereoselective total synthesis of (+)-artemisinin. Tetrahedron 66:11, pages 2005-2009.
Crossref
Rafael Zárate. 2010. Comprehensive Natural Products II. Comprehensive Natural Products II 629 668 .
P.W. Groundwater, R.J. Anderson & M. Nyerges. 2008. Comprehensive Heterocyclic Chemistry III. Comprehensive Heterocyclic Chemistry III 847 913 .
Geoffrey D Brown & Lai-King Sy. (2004) Synthesis of labelled dihydroartemisinic acid. Tetrahedron 60:5, pages 1125-1138.
Crossref
Donald J. AbrahamDee Ann Casteel. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 919 1031 .
Lai-King Sy & Geoffrey D Brown. (2002) The mechanism of the spontaneous autoxidation of dihydroartemisinic acid. Tetrahedron 58:5, pages 897-908.
Crossref
Richard K. Haynes, Kwok-Ping Lam, Kit-Ying Wu & Lam-Lung Yeung. (1999) An improved preparation of the desmethyl qinghao acid precursor of (±)-6,9-desmethylqinghaosu. Tetrahedron 55:33, pages 10087-10100.
Crossref
Ram P. Sharma & Asish K. Bhattacharya. (1999) Recent Developments on the Chemistry and Biological Activity of Artemisinin and Related Antimalarials — An Update. HETEROCYCLES 51:7, pages 1681.
Crossref
David H. Grayson. (1998) Monoterpenoids. Natural Product Reports 15:5, pages 439.
Crossref
Braulio M. Fraga. (1998) Natural sesquiterpenoids. Natural Product Reports 15:1, pages 73.
Crossref
Asish K Bhattacharya, Dharam C Jain, Ram P Sharma, Raja Roy & Andrew T McPhail. (1997) Boron trifluoride-acetic anhydride catalysed rearrangement of dihydroarteannuin B. Tetrahedron 53:44, pages 14975-14990.
Crossref
M. Hamzaoui, O. Provot, F. Grégoire, C. Riche, A. Chiaroni, F. Gay, H. Moskowitz & J. Mayrargue. (1997) Enantioselective synthesis of functionalized 2-oxo-cyclohexane carbonitriles. Access to a trioxane analogue of artemisinin. Tetrahedron: Asymmetry 8:13, pages 2085-2088.
Crossref
Saumitra Sengupta, Subir Kumar Sadhukhan & Sanchita Bhattacharyya. (1997) Probing the effect of gegenions in Heck reactions of arenediazonium salts: Arenediazonium perchlorates and fluorides as new Heck-substrates. Tetrahedron 53:6, pages 2213-2218.
Crossref
Charles W. Jefford. 1997. 271 325 .
M. G. CONSTANTINO, M. JUN. BELTRAME, G. V. JOSE DA SILVA & J. ZUKERMAN‐SCHPECTOR. (2010) ChemInform Abstract: A Novel Asymmetric Total Synthesis of (+)‐Artemisinin.. ChemInform 27:24.
Crossref
. 1996. Comprehensive Heterocyclic Chemistry II. Comprehensive Heterocyclic Chemistry II 1177 1307 .
Charles W. Jefford. 1996. Comprehensive Heterocyclic Chemistry II. Comprehensive Heterocyclic Chemistry II 861 899 .
Chiara Ghiron & Russell J. ThomasChiara Ghiron & Russell J. Thomas. 1999. Übungen zur organischen Synthese. Übungen zur organischen Synthese 34 35 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.