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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 26, 1996 - Issue 3
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Original Articles

Preparation of 2,4-Dihydroxybenzaldehyde by the Vilsmeier-Haack Reaction

Wilford L. Mendelson Synthetic Chemistry Department, SmithKline Beecham Pharmaceuticals, Post Office Box 1539, King of Prussia, PA, 19406–0939
&
Stuart Hayden Synthetic Chemistry Department, SmithKline Beecham Pharmaceuticals, Post Office Box 1539, King of Prussia, PA, 19406–0939
Pages 603-610 | Received 08 Jul 1995, Published online: 21 Aug 2006

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AhmedM. A. El-Seidy, Eman El-Zahany, AtiatS. Barakat, NabilS. Youssef, ShadiaA. Galal & SayedA. Drweesh. (2013) Synthesis, Characterization, and Cytotoxic Activity on MCF-7 Cell Line of Some Novel Metal Complexes With Substituted Benzimidazole Ligands. Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry 43:1, pages 46-56.
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Hong-Bin Zou, Liang Zhang, Lei-Xiang Yang, Liu-Qing Yang, Yu Zhao, Yong-Ping Yu & Joachim Stöckigt. (2011) Synthesis and structure–activity relationship studies of cytotoxic cinnamic alcohol derivatives. Natural Product Research 25:3, pages 203-221.
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S. A. Popova, E. V. Pavlova, O. G. Shevchenko, I. Yu. Chukicheva & A. V. Kutchin. (2022) Substituted chalcones with different positions of the isobornyl substituent: the synthesis and antioxidant activity. Russian Chemical Bulletin 71:11, pages 2383-2394.
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N. A. Gromak, F. A. Kolokolov, V. V. Dotsenko, N. A. Aksenov & I. V. Aksenova. (2021) Synthesis and Luminescent Properties of Eu3+ and Tb3+ Complexes with Coumarin-3-carboxylic Acids. Russian Journal of General Chemistry 91:4, pages 685-692.
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Maddali L. N. Rao & Boddu S. Ramakrishna. (2017) Rhodium-Catalyzed Directing-Group-Assisted Aldehydic C-H Arylations with Aryl Halides. European Journal of Organic Chemistry 2017:34, pages 5080-5093.
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Amol G. Jadhav & Nagaiyan Sekar. (2017) Substituent Modulation from ESIPT to ICT Emission in Benzoimidazolphenyl-methanones Derivatives: Synthesis, Photophysical and DFT Study. Journal of Solution Chemistry 46:4, pages 777-797.
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Maddali L. N. Rao & Boddu S. Ramakrishna. (2016) Rh-catalyzed direct synthesis of 2,2′-dihydroxybenzophenones and xanthones. RSC Advances 6:79, pages 75505-75511.
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Sayan Dutta Gupta, B. Revathi, Gisela I. Mazaira, Mario D. Galigniana, C.V.S. Subrahmanyam, N.L. Gowrishankar & N.M. Raghavendra. (2015) 2,4-dihydroxy benzaldehyde derived Schiff bases as small molecule Hsp90 inhibitors: Rational identification of a new anticancer lead. Bioorganic Chemistry 59, pages 97-105.
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Olimpo García-Beltrán, Osvaldo Yañez, Julio Caballero, Antonio Galdámez, Natalia Mena, Marco T. Nuñez & Bruce K. Cassels. (2014) Synthesis of coumarin derivatives as fluorescent probes for membrane and cell dynamics studies. European Journal of Medicinal Chemistry 76, pages 79-86.
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亚楼 王. (2014) Design and Synthesis of the Derivative of Erythribyssin H. Hans Journal of Medicinal Chemistry 02:02, pages 14-19.
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F. Aigbirhio, M. V. C. L. Appleyard, R. L. Arrowsmith, S. A. Baldwin, M. Bayrakdarian, N. P. Botting, L. D. Cantin, D. R. Carbery, M. A. Carroll, L. I. Dixon, P. N. Dorff, G. Ellames, C. S. Elmore, C. W. G. Fishwick, O. Foot, N. J. Geach, J. Gowdy, R. S. Grainger, T. Gregson, W. R. R. Harker, P. J. F. Henderson, J. R. Heys, S. W. Homans, Z. Hu, S. Jackson, J. Johnston, P. Johnson, A. Kalverda, C. Kay, S. L. Kitson, B. Lanoue, M. H. Levitt, Y. Li, W. J. S. Lockley, X Luo, P. Ma, D. A. Middleton, J. Newsome, B. Pandya, S. I. Pascu, S. G. Patching, M. K. Phillips-Jones, M. E. Powell, P. Riss, J. Simmons, T. M. Simpson, A. D. Smith, A. M. Thompson, L. Trembleau, R. Turtle, K. W. Watters & Q. Zhang. (2012) Abstracts of the 20th International Isotope Society (UK group) Symposium: Synthesis & Applications of Labelled Compounds 2011. Journal of Labelled Compounds and Radiopharmaceuticals 55:3, pages 125-134.
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Qingzhi Zhang, Nigel P. Botting & Colin Kay. (2011) A gram scale synthesis of a multi-13C-labelled anthocyanin, [6,8,10,3′,5′-13C5]cyanidin-3-glucoside, for use in oral tracer studies in humans. Chemical Communications 47:38, pages 10596.
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Zerong Wang. 2010. Comprehensive Organic Name Reactions and Reagents. Comprehensive Organic Name Reactions and Reagents.
F. Aldabbagh. 2005. Comprehensive Organic Functional Group Transformations II. Comprehensive Organic Functional Group Transformations II 99 133 .
I. A. Rivero, K. A. Espinoza & A. Ochoa. (2004) The Use of Solid-Phase Supported 1- N -Piperazine-4- N -carboxaldehyde in Vilsmeier Reactions . Journal of Combinatorial Chemistry 6:2, pages 270-274.
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S Ramadas & G.L.David Krupadanam. (2000) Enantioselective acylation of 2-hydroxymethyl-2,3-dihydrobenzofurans catalysed by lipase from Pseudomonas cepacia (Amano PS) and total stereoselective synthesis of (−)-(R)-MEM-protected arthrographol. Tetrahedron: Asymmetry 11:16, pages 3375-3393.
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W. L. MENDELSON & S. HAYDEN. (2010) ChemInform Abstract: Preparation of 2,4‐Dihydroxybenzaldehyde by the Vilsmeier‐Haack Reaction.. ChemInform 27:24.
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