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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 26, 1996 - Issue 4
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Original Articles

A facile large scale synthesis of optically active 3-amino-5-(2-pyridyl)-1,4-benzodiazepin-2-one derivatives

Graeme Semple Ferring Research Institute, Chilworth Research Centre, Chilworth, Southampton, U.K., S016 7NP
,
Hamish Ryder Ferring Research Institute, Chilworth Research Centre, Chilworth, Southampton, U.K., S016 7NP
,
Mitsuaki Ohta Neuroscience & Gastrointestinal Research Laboratories, Yamanouchi Institute for Drug Discovery Research, 21, Miyukigaoka, Tsukuba, Ibaraki, 305, Japan
&
Masato Satoh Neuroscience & Gastrointestinal Research Laboratories, Yamanouchi Institute for Drug Discovery Research, 21, Miyukigaoka, Tsukuba, Ibaraki, 305, Japan
Pages 721-727 | Received 27 Jul 1995, Published online: 21 Nov 2007

Citations (9)

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Read on this site (1)

Chengde Wu, RonaldJ. Biediger & TimothyP. Kogan. (1999) A Highly Practical Route to 7-Hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one from p-Anisidine. Synthetic Communications 29:20, pages 3509-3516.
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Articles from other publishers (8)

Min Liu, Xue Chen, Tieqiao Chen, Qing Xu & Shuang-Feng Yin. (2017) Metal-free oxidative para -acylation of unprotected anilines with N-heteroarylmethanes . Organic & Biomolecular Chemistry 15:46, pages 9845-9854.
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Olivier Mirguet, Romain Gosmini, Jérôme Toum, Catherine A. Clément, Mélanie Barnathan, Jean-Marie Brusq, Jacqueline E. MordauntRichard M. GrimesMiriam CroweOlivier Pineau, Myriam Ajakane, Alain Daugan, Phillip JeffreyLeanne CutlerAndrea C. HaynesNicholas N. SmithersChun-wa ChungPaul BamboroughIain J. UingsAntonia LewisJason WitheringtonNigel ParrRab K. PrinjhaEdwige Nicodème. (2013) Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains. Journal of Medicinal Chemistry 56:19, pages 7501-7515.
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John Spencer, Rajendra P. Rathnam, Alan L. Harvey, Carol J. Clements, Rachel L. Clark, Michael P. Barrett, Pui Ee Wong, Louise Male, Simon J. Coles & Simon P. Mackay. (2011) Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity. Bioorganic & Medicinal Chemistry 19:5, pages 1802-1815.
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Xu‐Chang He & Chuang‐Yu Qi. (2007) Practical Tactics in Resolution of Racemates via Diastereomeric Salt Formation. Chinese Journal of Chemistry 25:5, pages 583-586.
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Iain M. McDonaldCarol AustinIldiko M. BuckDavid J. DunstoneEric GriffinElaine A. HarperRobert A. D. HullS. Barret KalindjianIan D. LinneyCaroline M. R. LowMichael J. PetherJohn SpencerPaul T. WrightTrushar AdatiaAlan Bashall. (2006) Novel, Achiral 1,3,4-Benzotriazepine Analogues of 1,4-Benzodiazepine-Based CCK 2 Antagonists That Display High Selectivity over CCK 1 Receptors . Journal of Medicinal Chemistry 49:7, pages 2253-2261.
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Matthias Nettekoven. (2000) A combinatorial approach towards 2-acyl-3-amino-indole derivatives. Tetrahedron Letters 41:43, pages 8251-8254.
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Graeme Semple, Hamish Ryder, David P. Rooker, Andrzej R. Batt, David A. Kendrick, Michael Szelke, Mitsuaki Ohta, Masato Satoh, Akito Nishida, Shinobu Akuzawa & Keiji Miyata. (1997) (3 R )- N -(1-( tert -Butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1 H - 1,4-benzodiazepin-3-yl)- N ‘-(3-(methylamino)phenyl)urea (YF476):  A Potent and Orally Active Gastrin/CCK-B Antagonist . Journal of Medicinal Chemistry 40:3, pages 331-341.
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G. SEMPLE, H. RYDER, M. OHTA & M. SATOH. (2010) ChemInform Abstract: A Facile Large Scale Synthesis of Optically Active 3‐Amino‐5‐(2‐ pyridyl)‐1,4‐benzodiazepin‐2‐one Derivatives.. ChemInform 27:24.
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