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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 27, 1997 - Issue 4
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Original Articles

A Convenient One Pot Procedure for N-Methylation of Aromatic Amines Using Trimethyl Orthoformate

Seetharamaiyer Padmanabhan Cambridge NeuroScience Inc., One Kendall Square, Building #700, Cambridge, MA, 02139, U.S.A.
,
N. Laxma Reddy Cambridge NeuroScience Inc., One Kendall Square, Building #700, Cambridge, MA, 02139, U.S.A.
&
Graham J. Durant Cambridge NeuroScience Inc., One Kendall Square, Building #700, Cambridge, MA, 02139, U.S.A.
Pages 691-699 | Received 16 Aug 1996, Published online: 20 Aug 2006

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Yeon Joo Jung, Jong Woo Bae, Choon-Ock Maing Yoon, Byung Woo Yoo & Cheol Min Yoon. (2001) REDUCTIVE METHYLATION USING DECABORANE IN METHANOL. Synthetic Communications 31:22, pages 3417-3421.
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Articles from other publishers (19)

Osama I. Alwassil, Shailesh Khatri, Marvin K. Schulte, Sanjay S. Aripaka, Jens D. Mikkelsen & Małgorzata Dukat. (2021) N 1 H- and N 1 -Substituted Phenylguanidines as α7 Nicotinic Acetylcholine (nACh) Receptor Antagonists: Structure–Activity Relationship Studies . ACS Chemical Neuroscience 12:12, pages 2194-2201.
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Rebecca E Ruscoe, Jeremy I Ramsden & Nicholas J Turner. (2020) Redox surrogate methods for sustainable amine N-alkylation. Current Opinion in Chemical Engineering 30, pages 60-68.
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Zahra Khademi & Kobra Nikoofar. (2020) Applications of alkyl orthoesters as valuable substrates in organic transformations, focusing on reaction media. RSC Advances 10:51, pages 30314-30397.
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Jose R. Cabrero‐Antonino, Rosa Adam & Matthias Beller. (2019) Catalytic Reductive N‐Alkylations Using CO 2 and Carboxylic Acid Derivatives: Recent Progress and Developments . Angewandte Chemie International Edition 58:37, pages 12820-12838.
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Jose R. Cabrero‐Antonino, Rosa Adam & Matthias Beller. (2019) Katalytische reduktive N‐Alkylierungen unter Verwendung von CO 2 und Carbonsäurederivaten: Aktuelle Entwicklungen . Angewandte Chemie 131:37, pages 12950-12968.
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Dabir S. Viswanath, Tushar K. Ghosh & Veera M. BodduDabir S. Viswanath, Tushar K. Ghosh & Veera M. Boddu. 2018. Emerging Energetic Materials: Synthesis, Physicochemical, and Detonation Properties. Emerging Energetic Materials: Synthesis, Physicochemical, and Detonation Properties 233 241 .
Yuehui Li, Xinjiang Cui, Kaiwu Dong, Kathrin Junge & Matthias Beller. (2017) Utilization of CO 2 as a C1 Building Block for Catalytic Methylation Reactions . ACS Catalysis 7:2, pages 1077-1086.
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Gregory R. Naumiec, Kimberley J. Jenko, Sami S. Zoghbi, Robert B. Innis, Lisheng Cai & Victor W. Pike. (2015) N ′-3-(Trifluoromethyl)phenyl Derivatives of N -Aryl- N ′-methylguanidines as Prospective PET Radioligands for the Open Channel of the N -Methyl- d -aspartate (NMDA) Receptor: Synthesis and Structure–Affinity Relationships . Journal of Medicinal Chemistry 58:24, pages 9722-9730.
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Gregory R. Naumiec, Lisheng Cai & Victor W. Pike. (2015) New N-aryl-N′-(3-(substituted)phenyl)-N′-methylguanidines as leads to potential PET radioligands for imaging the open NMDA receptor. Bioorganic & Medicinal Chemistry Letters 25:2, pages 225-228.
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Guy Crépin Enoua, Günther Lahm, Georg Uray & Wolfgang Stadlbauer. (2014) Syntheses and Fluorescent Properties of 6-Methoxy-2-oxoquinoline-3,4-dicarbonitriles and 6,7-Dimethoxy-2-oxoquinoline-3,4-dicarbonitriles. Journal of Heterocyclic Chemistry 51:S1, pages E263-E275.
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Ping-An Wang, Sheng-Yong Zhang & Henri B Kagan. (2013) One-pot tandem cyclization of enantiopure asymmetric cis -2,5-disubstituted pyrrolidines: Facile access to chiral 10-heteroazatriquinanes . Beilstein Journal of Organic Chemistry 9, pages 265-269.
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Nan Sun, Shuai Wang, Weimin Mo, Baoxiang Hu, Zhenlu Shen & Xinquan Hu. (2010) A facile protocol for the synthesis of mono-N-methyl anilines via formimidate intermediates. Tetrahedron 66:35, pages 7142-7148.
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Ravi Kumar & Prem M.S. Chauhan. (2008) A one-pot chemoselective S-alkylation and acetylation of thiohydantoins using the alkyl orthoformate–ZnCl2–Ac2O reagent system. Tetrahedron Letters 49:38, pages 5475-5479.
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David R. Armstrong, William Clegg, Sophie H. Dale, Eva Hevia, Lorna M. Hogg, Gordon W. Honeyman & Robert E. Mulvey. (2006) Directed meta ‐Metalation Using Alkali‐Metal‐Mediated Zincation . Angewandte Chemie International Edition 45:23, pages 3775-3778.
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David R. Armstrong, William Clegg, Sophie H. Dale, Eva Hevia, Lorna M. Hogg, Gordon W. Honeyman & Robert E. Mulvey. (2006) Directed meta ‐Metalation Using Alkali‐Metal‐Mediated Zincation . Angewandte Chemie 118:23, pages 3859-3862.
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Augustin Adima, Catherine Bied, Joël J. E Moreau & Michel Wong Chi Man. (2004) Facile Cleavage of Si−C Bonds during the Sol-Gel Hydrolysis of Aminomethyltrialkoxysilanes− A New Method for the Methylation of Primary Amines. European Journal of Organic Chemistry 2004:12, pages 2582-2588.
Crossref
Michael B. Smith. 2002. Compendium of Organic Synthetic Methods. Compendium of Organic Synthetic Methods 118 138 .
H.M. Sampath Kumar, B.V. Subba Reddy, S. Anjaneyulu & J.S. Yadav. (1999) A novel and efficient approach to mono-N-alkyl anilines via addition of grignard reagents to aryl azides. Tetrahedron Letters 40:47, pages 8305-8306.
Crossref
S. PADMANABHAN, N. L. REDDY & G. J. DURANT. (2010) ChemInform Abstract: A Convenient One‐Pot Procedure for N‐Methylation of Aromatic Amines Using Trimethyl Orthoformate.. ChemInform 28:26.
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