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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 27, 1997 - Issue 14
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Original Articles

A Simple and Efficient New Approach to the Total Synthesis of (±)-4-Amino-3-(4-Chlorophenyl)-Butyric Acid (BACLOFEN)

Fernando Coelho UNICAMP - Instituto de Química, Depto. de Química Orgânica, P.O. Box 6154, 13083-970, Campinas, SP, BRAZIL
,
Mariangela B. M. de Azevedo UNICAMP - Instituto de Química, Depto. de Química Orgânica, P.O. Box 6154, 13083-970, Campinas, SP, BRAZIL
,
Roberta Boschiero UNICAMP - Instituto de Química, Depto. de Química Orgânica, P.O. Box 6154, 13083-970, Campinas, SP, BRAZIL
&
Patrícia Resende UNICAMP - Instituto de Química, Depto. de Química Orgânica, P.O. Box 6154, 13083-970, Campinas, SP, BRAZIL
Pages 2455-2465 | Received 06 Feb 1997, Published online: 21 Aug 2006

Citations (9)

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Ravi Varala & Srinivas R. Adapa. (2006) Novel Approach to the Synthesis of (R,S)‐Baclofen via PD(II)‐Bipyridine–Catalyzed Conjugative Addition. Synthetic Communications 36:24, pages 3743-3747.
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Articles from other publishers (8)

Ishin Tomiya, Yuhao Wu & Kengo Hyodo. (2024) Ring‐Opening Amino Esterification of Cyclic Ketones to Access Distal Amino Acid Derivatives. Advanced Synthesis & Catalysis 366:7, pages 1606-1614.
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Saeed Kakaei & Elham Sattarzadeh Khameneh. (2018) An efficient and simple ultrasound-assisted approach to synthesis of Baclofen. Main Group Chemistry 17:2, pages 161-164.
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Daniel González-Martínez, María Rodríguez-Mata, Daniel Méndez-Sánchez, Vicente Gotor & Vicente Gotor-Fernández. (2015) Lactonization reactions through hydrolase-catalyzed peracid formation. Use of lipases for chemoenzymatic Baeyer–Villiger oxidations of cyclobutanones. Journal of Molecular Catalysis B: Enzymatic 114, pages 31-36.
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Kallolmay Biswas, Rajesh Gholap, Padakanti Srinivas, Sachin Kanyal & Koushik Das Sarma. (2014) β-Substituted γ-butyrolactams from mucochloric acid: synthesis of (±)-baclofen and other γ-aminobutyric acids and useful building blocks. RSC Advances 4:5, pages 2538-2545.
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Krzysztof Błaszczyk, Hanna Koenig, Katarzyna Mel & Zdzisław Paryzek. (2006) Abnormal Beckmann rearrangement of steroidal α-chlorocyclobutanone oximes: the fragmentation–substitution reaction. Tetrahedron 62:6, pages 1069-1078.
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Albertina G. Moglioni, Beatriz N. Brousse, Angel Álvarez-Larena, Graciela Y. Moltrasio & Rosa M. Ortuño. (2002) Stereoselective synthesis of cyclobutyl GABA analogues and related compounds from (−)-(S)-verbenone. Tetrahedron: Asymmetry 13:5, pages 451-454.
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Patrı́cia Resende, Wanda P. Almeida & Fernando Coelho. (1999) An efficient synthesis of (R)-(−)-baclofen. Tetrahedron: Asymmetry 10:11, pages 2113-2118.
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F. COELHO, M. B. M. DE AZEVEDO, R. BOSCHIERO & P. RESENDE. (2010) ChemInform Abstract: A Simple and Efficient New Approach to the Total Synthesis of (.+‐.)‐4‐ Amino‐3‐(4‐chlorophenyl)‐butyric Acid (Baclofen).. ChemInform 28:38.
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