A Convenient Synthesis of 3- and 3,4-Substituted 4,5-Dihydroisoxazole-5-Acetic Acids

Karl Eichinger Institute of Organic Chemistry, Vienna University of Technology, Getreidemarkt 9, A-1060, Vienna, Austria

Michael Wokurek Institute of Organic Chemistry, Vienna University of Technology, Getreidemarkt 9, A-1060, Vienna, Austria

Bernd Zauner Institute of Organic Chemistry, Vienna University of Technology, Getreidemarkt 9, A-1060, Vienna, Austria

Mohammad Reza Rostami Institute of Organic Chemistry, Vienna University of Technology, Getreidemarkt 9, A-1060, Vienna, Austria

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Matthew J. Walters, S. Patrick Dunn, Emily Choi, Amanda N. D'Elia, Morgan E. Warner & Charles F. Beam. (2003) The Preparation of 5-Aryl-5-methyl-4,5-dihydroisoxazoles from Dilithiated C(α), -Oximes and Select Acetyl Ketones. Synthetic Communications 33:23, pages 4163-4171.
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Karl Eichinger, Mohammad RezaRostami & Florian Sieder. (1998) A Novel Base Promoted Reaction of Methyl 2-Isoxazoline-5-acetates to 5-(2-oxoethyl)-3-isoxazolidinones. Synthetic Communications 28:13, pages 2457-2466.
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Zohreh Mirjafary, Morteza Abdoli, Hamid Saeidian, Ali Kakanejadifard & S. Morteza F. Farnia. (2016) Review of the synthesis of acyclic and cyclic oxime ethers. RSC Advances 6:21, pages 17740-17758.
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E. Kleinpeter & M. Sefkow. 2008. Comprehensive Heterocyclic Chemistry III. Comprehensive Heterocyclic Chemistry III 739 856 .

Stanislava Stosic-Grujicic, Ivana Cvetkovic, Katia Mangano, Massimo Fresta, Danijela Maksimovic-Ivanic, Ljubica Harhaji, Dusan Popadic, Miljana Momcilovic, Djordje Miljkovic, Joseph Kim, Yousef Al Abed & Ferdinando Nicoletti. (2007) A Potent Immunomodulatory Compound, ( S,R )-3-Phenyl-4,5-dihydro-5-isoxasole Acetic Acid, Prevents Spontaneous and Accelerated Forms of Autoimmune Diabetes in NOD Mice and Inhibits the Immunoinflammatory Diabetes Induced by Multiple Low Doses of Streptozotocin in CBA/H Mice . Journal of Pharmacology and Experimental Therapeutics 320:3, pages 1038-1049.
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V. D. Dyachenko & R. P. Tkachev. (2006) Functionally-substituted alkoxyethylenes in reactions with nucleophiles: Part 2. Synthesis of noncyclic structures, benzene derivatives, 5-, 7-membered, and macroheterocycles. Russian Journal of Organic Chemistry 42:2, pages 149-171.
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K. EICHINGER, M. WOKUREK, B. ZAUNER & M. R. ROSTAMI. (2010) ChemInform Abstract: A Convenient Synthesis of 3‐ and 3,4‐Substituted 4,5‐Dihydroisoxazole‐ 5‐acetic Acids.. ChemInform 28:42.
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A Convenient Synthesis of 3- and 3,4-Substituted 4,5-Dihydroisoxazole-5-Acetic Acids

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A Convenient Synthesis of 3- and 3,4-Substituted 4,5-Dihydroisoxazole-5-Acetic Acids

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