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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 28, 1998 - Issue 24
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Original Articles

A Facile Route to Quinazolin-4(3H)-ones Functionalised at the 2-Position

V. Bavetsias CRC Centre for Cancer Therapeutics, The Institute of Cancer Research, CRC Laboratory, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK
Pages 4547-4559 | Received 08 Jun 1998, Published online: 22 Aug 2006

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Vishnuvardhan Nomula & Sadu Nageswara Rao. (2021) KOtBu-BF3.OEt2 mediated synthesis of quinazolin-4(3H)-ones from 2-substituted amides with nitriles and aldehydes. Synthetic Communications 51:17, pages 2602-2612.
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Articles from other publishers (18)

Navjeet Kaur. 2024. Synthesis of 6- and 7-Membered Heterocycles. Synthesis of 6- and 7-Membered Heterocycles 155 197 .
V. Kannappan, P. Vidhya & V. Sathyanarayanamoorthi. (2015) Quantum mechanical study of solvation analysis on some nitrogen containing heterocyclic compounds. Journal of Molecular Liquids 207, pages 7-13.
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Giuseppe Giannini, Gianfranco Battistuzzi, Loredana Vesci, Ferdinando M. Milazzo, Francesca De Paolis, Marcella Barbarino, Mario Berardino Guglielmi, Valeria Carollo, Grazia Gallo, Roberto Artali & Sabrina Dallavalle. (2014) Novel PARP-1 inhibitors based on a 2-propanoyl-3H-quinazolin-4-one scaffold. Bioorganic & Medicinal Chemistry Letters 24:2, pages 462-466.
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Anders E. G. Lindgren, Tobias Karlberg, Torun Ekblad, Sara Spjut, Ann-Gerd Thorsell, C. David Andersson, Ton Tong Nhan, Victor Hellsten, Johan Weigelt, Anna Linusson, Herwig Schüler & Mikael Elofsson. (2013) Chemical Probes to Study ADP-Ribosylation: Synthesis and Biochemical Evaluation of Inhibitors of the Human ADP-Ribosyltransferase ARTD3/PARP3. Journal of Medicinal Chemistry 56:23, pages 9556-9568.
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Hai-Yun He, Jin-Ni Zhao, Ruo Jia, Ying-Lan Zhao, Sheng-Yong Yang, Luo-Ting Yu & Li Yang. (2011) Novel Pyrazolo[3,4-d]pyrimidine Derivatives as Potential Antitumor Agents: Exploratory Synthesis, Preliminary Structure-Activity Relationships, and in Vitro Biological Evaluation. Molecules 16:12, pages 10685-10694.
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Hong-Ze Li, Hai-Yun He, Yuan-Yuan Han, Xin Gu, Lin He, Qing-Rong Qi, Ying-Lan Zhao & Li Yang. (2010) A General Synthetic Procedure for 2-chloromethyl-4(3H)-quinazolinone Derivatives and Their Utilization in the Preparation of Novel Anticancer Agents with 4-Anilinoquinazoline Scaffolds. Molecules 15:12, pages 9473-9485.
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Li Xiao-Hong & Zhang Xian-Zhou. (2010) The spectroscopic, NMR analysis of 1-(2,6-Dichloro-4-nitrophenyl)-5-amino-4-cyanopyrazole by ab initio HF and density functional methods. Journal of Molecular Structure: THEOCHEM 957:1-3, pages 15-20.
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Hao Wu, Xilei Xie & Gang Liu. (2010) Parallel Solution Phase Synthesis of 3,6,7−4(3 H )-Quinazolinones and Evaluation of Their Antitumor Activities against Human Cancer . Journal of Combinatorial Chemistry 12:3, pages 346-355.
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Youssef Kabri, Nadine Azas, Aurélien Dumètre, Sébastien Hutter, Michèle Laget, Pierre Verhaeghe, Armand Gellis & Patrice Vanelle. (2010) Original quinazoline derivatives displaying antiplasmodial properties. European Journal of Medicinal Chemistry 45:2, pages 616-622.
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Y. Kabri, A. Gellis & P. Vanelle. (2009) Microwave-assisted synthesis in aqueous medium of new quinazoline derivatives as anticancer agent precursors. Green Chem. 11:2, pages 201-208.
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Minoo Dabiri, Peyman Salehi & Mostafa Baghbanzadeh. (2008) A New Efficient Method for the Three-Component Synthesis of 4(3H)-Quinazolinones. HETEROCYCLES 75:11, pages 2809.
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G.W. Rewcastle. 2008. Comprehensive Heterocyclic Chemistry III. Comprehensive Heterocyclic Chemistry III 117 272 .
David J. Connolly, Declan Cusack, Timothy P. O'Sullivan & Patrick J. Guiry. (2005) Synthesis of quinazolinones and quinazolines. Tetrahedron 61:43, pages 10153-10202.
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Song Xue, Joseph McKenna, Wen-Chung Shieh & Oljan Repič. (2004) A Facile Synthesis of C 2 , N 3 -Disubstituted-4-quinazolone . The Journal of Organic Chemistry 69:19, pages 6474-6477.
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Kurosh Rad-Moghadam & Mehdi Mohseni. (2019) An Expeditious and Solvent-Free Route to the Synthesis of 2-Substituted Quinazolin-4(3 H )-Ones Under Microwave Conditions . Journal of Chemical Research 2003:8, pages 487-488.
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V. BavetsiasL. A. SkeltonF. YafaiF. MitchellS. C. WilsonB. AllanA. L. Jackman. (2002) The Design and Synthesis of Water-Soluble Analogues of CB30865, a Quinazolin-4-one-Based Antitumor Agent. Journal of Medicinal Chemistry 45:17, pages 3692-3702.
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V. Bavetsias. (2010) ChemInform Abstract: A Facile Route to Quinazolin‐4(3H)‐ones Functionalized at the 2‐Position.. ChemInform 30:12.
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Michael P. Groziak. 1999. A Critical Review of the 1998 Literature preceded by two Chapters on Current Heterocyclic Topics. A Critical Review of the 1998 Literature preceded by two Chapters on Current Heterocyclic Topics 256 275 .

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