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Scientific Article

Brave or gullible: Testing the concept that leaving susceptible parasites in refugia will slow the development of anthelmintic resistance

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Pages 158-163 | Received 04 Sep 2007, Accepted 15 Apr 2008, Published online: 18 Feb 2011

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TS Waghorn, CM Miller, A-MB Oliver & DM Leathwick. (2009) Drench-and-shift is a high-risk practice in the absence of refugia. New Zealand Veterinary Journal 57:6, pages 359-363.
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DM Leathwick, BC Hosking, SA Bisset & CH McKay. (2009) Managing anthelmintic resistance: Is it feasible in New Zealand to delay the emergence of resistance to a new anthelmintic class?. New Zealand Veterinary Journal 57:4, pages 181-192.
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Erwin van den Enden. (2009) Pharmacotherapy of helminth infection. Expert Opinion on Pharmacotherapy 10:3, pages 435-451.
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Brown Besier. (2009) A novel anthelmintic group: Welcome relief for sheep farmers. New Zealand Veterinary Journal 57:1, pages 1-2.
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Johan Höglund & Katarina Gustafsson. (2023) Anthelmintic Treatment of Sheep and the Role of Parasites Refugia in a Local Context. Animals 13:12, pages 1960.
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Katja Voigt, Maximilian Geiger & Miriam Jäger. (2023) Fünf nach zwölf – zur Resistenzlage gastrointestinaler Nematoden bei kleinen Wiederkäuern in Deutschland. Tierärztliche Praxis Ausgabe G: Großtiere / Nutztiere 51:03, pages 153-159.
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Niclas Högberg, Anna Hessle, Lena Lidfors & Johan Höglund. (2023) The effect of weaning age on animal performance in lambs exposed to naturally acquired nematode infections. Veterinary Parasitology 316, pages 109900.
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Andrew W. Greer, Jan A. Van Wyk, Joseph C. Hamie, Charles Byaruhanga & Fiona Kenyon. (2020) Refugia-Based Strategies for Parasite Control in Livestock. Veterinary Clinics of North America: Food Animal Practice 36:1, pages 31-43.
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Sergey Engashev, Ekaterina Engasheva, Vladimir Kolesnikov, Natalia Koshkina, Maria Lopteva & Konstantin Katkov. (2020) Effectiveness of the new Iverlong prolonged-release drug for gastrointestinal nematodoses in sheep. E3S Web of Conferences 210, pages 06011.
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Sherrill A. Fleming, Martin K. Nielsen & Lora Rickard Ballweber. 2020. Large Animal Internal Medicine. Large Animal Internal Medicine 1669 1693.e5 .
Dave M. Leathwick, Christian W. Sauermann & Martin K. Nielsen. (2019) Managing anthelmintic resistance in cyathostomin parasites: Investigating the benefits of refugia-based strategies. International Journal for Parasitology: Drugs and Drug Resistance 10, pages 118-124.
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David Baines, David Newborn & Michael Richardson. (2019) Are Trichostrongylus tenuis control and resistance avoidance simultaneously manageable by reducing anthelmintic intake by grouse? . Veterinary Record 185:2, pages 53-53.
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Andrea M. Harvey, Maira N. Meggiolaro, Evelyn Hall, Ellyssia T. Watts, Daniel Ramp & Jan Šlapeta. (2019) Wild horse populations in south-east Australia have a high prevalence of Strongylus vulgaris and may act as a reservoir of infection for domestic horses. International Journal for Parasitology: Parasites and Wildlife 8, pages 156-163.
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Martin K. Nielsen & Craig R. Reinemeyer. 2018. Handbook of Equine Parasite Control. Handbook of Equine Parasite Control 99 109 .
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Kim Hamer, Dave Bartley, Amy Jennings, Alison Morrison & Neil Sargison. (2018) Lack of efficacy of monepantel against trichostrongyle nematodes in a UK sheep flock. Veterinary Parasitology 257, pages 48-53.
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J. Charlier, S. M. Thamsborg, D. J. Bartley, P. J. Skuce, F. Kenyon, T. Geurden, H. Hoste, A. R. Williams, S. Sotiraki, J. Höglund, C. Chartier, P. Geldhof, J. van Dijk, L. Rinaldi, E. R. Morgan, G. von Samson-Himmelstjerna, J. Vercruysse & E. Claerebout. (2018) Mind the gaps in research on the control of gastrointestinal nematodes of farmed ruminants and pigs. Transboundary and Emerging Diseases 65, pages 217-234.
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Dave M. Leathwick, Christian W. Sauermann, Thomas Geurden & Martin K. Nielsen. (2017) Managing anthelmintic resistance in Parascaris spp.: A modelling exercise. Veterinary Parasitology 240, pages 75-81.
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T. Westers, A. Jones-Bitton, P. Menzies, J. VanLeeuwen, Z. Poljak & A.S. Peregrine. (2017) Comparison of targeted selective and whole flock treatment of periparturient ewes for controlling Haemonchus sp. on sheep farms in Ontario, Canada. Small Ruminant Research 150, pages 102-110.
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R. G. Woodgate, A. J. Cornell & N. C. Sangster. 2017. Antimicrobial Drug Resistance. Antimicrobial Drug Resistance 1305 1326 .
Lynsey A Melville, David McBean, Alex Fyfe, Sara-Jane Campbell, Javier Palarea-Albaladejo & Fiona Kenyon. (2016) Effect of anthelmintic treatment strategy on strongylid nematode species composition in grazing lambs in Scotland. Parasites & Vectors 9:1.
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James Patrick Crilly & Neil D Sargison. (2016) Macrocyclic lactone resistance on new grass leys — the putative role of accidental ‘dose-and-move’ strategies due to use of persistent macrocyclic lactone products. Livestock 21:3, pages 174-178.
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Charlotte F. Bolwell, Sarah M. Rosanowski, Ian Scott, Patrick D. Sells & Chris W. Rogers. (2015) Questionnaire study on parasite control practices on Thoroughbred and Standardbred breeding farms in New Zealand. Veterinary Parasitology 209:1-2, pages 62-69.
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L.C. Falzon, T.J. O’Neill, P.I. Menzies, A.S. Peregrine, A. Jones-Bitton, J. vanLeeuwen & A. Mederos. (2014) A systematic review and meta-analysis of factors associated with anthelmintic resistance in sheep. Preventive Veterinary Medicine 117:2, pages 388-402.
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Jie Xu, Anand Vidyashankar & Martin K. Nielsen. (2014) Drug Resistance or Re-Emergence? Simulating Equine Parasites. ACM Transactions on Modeling and Computer Simulation 24:4, pages 1-23.
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D.M. Leathwick & R.B. Besier. (2014) The management of anthelmintic resistance in grazing ruminants in Australasia—Strategies and experiences. Veterinary Parasitology 204:1-2, pages 44-54.
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M.J. McArthur & C.R. Reinemeyer. (2014) Herding the U.S. cattle industry toward a paradigm shift in parasite control. Veterinary Parasitology 204:1-2, pages 34-43.
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M.K. Nielsen, C.R. Reinemeyer, J.M. Donecker, D.M. Leathwick, A.A. Marchiondo & R.M. Kaplan. (2014) Anthelmintic resistance in equine parasites?Current evidence and knowledge gaps. Veterinary Parasitology 204:1-2, pages 55-63.
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M.K. Nielsen, K. Pfister & G. von Samson-Himmelstjerna. (2014) Selective therapy in equine parasite control?Application and limitations. Veterinary Parasitology 202:3-4, pages 95-103.
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D.M. Leathwick. (2014) Sustainable control of nematode parasites – A New Zealand perspective. Small Ruminant Research 118:1-3, pages 31-34.
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YAN C. S. M. LAURENSON, STEPHEN C. BISHOP, ANDREW B. FORBES & ILIAS KYRIAZAKIS. (2013) Modelling the short- and long-term impacts of drenching frequency and targeted selective treatment on the performance of grazing lambs and the emergence of anthelmintic resistance. Parasitology 140:6, pages 780-791.
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P.J. Skuce, E.R. Morgan, J. van Dijk & M. Mitchell. (2013) Animal health aspects of adaptation to climate change: beating the heat and parasites in a warming Europe. Animal 7, pages 333-345.
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R.B. Besier. (2012) Refugia-based strategies for sustainable worm control: Factors affecting the acceptability to sheep and goat owners. Veterinary Parasitology 186:1-2, pages 2-9.
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R.J. Dobson, B.C. Hosking, C.L. Jacobson, J.L. Cotter, R.B. Besier, P.A. Stein & S.A. Reid. (2012) Preserving new anthelmintics: A simple method for estimating faecal egg count reduction test (FECRT) confidence limits when efficacy and/or nematode aggregation is high. Veterinary Parasitology 186:1-2, pages 79-92.
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Ray M. Kaplan & Anand N. Vidyashankar. (2012) An inconvenient truth: Global worming and anthelmintic resistance. Veterinary Parasitology 186:1-2, pages 70-78.
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David J. Bartram, Dave M. Leathwick, Mike A. Taylor, Thomas Geurden & Steven J. Maeder. (2012) The role of combination anthelmintic formulations in the sustainable control of sheep nematodes. Veterinary Parasitology 186:3-4, pages 151-158.
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María-Gloria Basáñez, James S. McCarthy, Michael D. French, Guo-Jing Yang, Martin Walker, Manoj Gambhir, Roger K. Prichard & Thomas S. Churcher. (2012) A Research Agenda for Helminth Diseases of Humans: Modelling for Control and Elimination. PLoS Neglected Tropical Diseases 6:4, pages e1548.
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Joshua P.A. Sweeny, Graham E. Gardner, Robert J. Dobson, Caroline Jacobson & Kevin Bell. (2011) Associations between trichostrongylid worm egg count and productivity measures in Dorper lambs. Veterinary Parasitology 180:3-4, pages 307-314.
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RJ Dobson, BC Hosking, RB Besier, S Love, JWA Larsen, PF Rolfe & JN Bailey. (2011) Minimising the development of anthelmintic resistance, and optimising the use of the novel anthelmintic monepantel, for the sustainable control of nematode parasites in Australian sheep grazing systems. Australian Veterinary Journal 89:5, pages 160-166.
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D.P. Reynecke, J.A. Van Wyk, B. Gummow, P. Dorny & J. Boomker. (2011) A stochastic model accommodating the FAMACHA© system for estimating worm burdens and associated risk factors in sheep naturally infected with Haemonchus contortus. Veterinary Parasitology 177:3-4, pages 231-241.
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J.A. van Wyk & D.P. Reynecke. (2011) Blueprint for an automated specific decision support system for countering anthelmintic resistance in Haemonchus spp. at farm level. Veterinary Parasitology 177:3-4, pages 212-223.
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Neil D. Sargison. (2011) Pharmaceutical Control of Endoparasitic Helminth Infections in Sheep. Veterinary Clinics of North America: Food Animal Practice 27:1, pages 139-156.
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Ruth Cox, David Newborn, David Baines, Christopher J. Thomas & Thomas N. Sherratt. (2010) No Evidence for Resistance to Fenbendazole in Trichostrongylus tenuis , a Nematode Parasite of the Red Grouse . The Journal of Wildlife Management 74:8, pages 1799-1805.
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R. M. Kaplan & M. K. Nielsen. (2010) An evidence‐based approach to equine parasite control: It ain't the 60s anymore. Equine Veterinary Education 22:6, pages 306-316.
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R. B. Besier, R. A. Love, J. Lyon & A. J. van Burgel. (2010) A targeted selective treatment approach for effective and sustainable sheep worm management: investigations in Western Australia. Animal Production Science 50:12, pages 1034.
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R. G. Woodgate & R. B. Besier. (2010) Sustainable use of anthelmintics in an Integrated Parasite Management Program for sheep nematodes. Animal Production Science 50:6, pages 440.
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G.F. Bath & J.A. van Wyk. (2009) The Five Point Check© for targeted selective treatment of internal parasites in small ruminants. Small Ruminant Research 86:1-3, pages 6-13.
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M.L. Steinauer, B. Hanelt, L.E. Agola, G.M. Mkoji & E.S. Loker. (2009) Genetic structure of Schistosoma mansoni in western Kenya: The effects of geography and host sharing. International Journal for Parasitology 39:12, pages 1353-1362.
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