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New Zealand Veterinary Journal Volume 63, 2015 - Issue 4
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Scientific Articles

Comparative pharmacokinetic and pharmacodynamic response of single and double intraruminal doses of ivermectin and moxidectin in nematode-infected lambs

M LloberasLaboratorio de Parasitología, EEA INTA Balcarce, Balcarce, Argentina
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L AlvarezLaboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), CONICET, Facultad de Ciencias Veterinarias, UNCPBA, Tandil, BA(7000), Argentina
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C EntrocassoLaboratorio de Parasitología, EEA INTA Balcarce, Balcarce, Argentina
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M BallentLaboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), CONICET, Facultad de Ciencias Veterinarias, UNCPBA, Tandil, BA(7000), Argentina
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G VirkelLaboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), CONICET, Facultad de Ciencias Veterinarias, UNCPBA, Tandil, BA(7000), Argentina
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S LuqueLaboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), CONICET, Facultad de Ciencias Veterinarias, UNCPBA, Tandil, BA(7000), Argentina
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C LanusseLaboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), CONICET, Facultad de Ciencias Veterinarias, UNCPBA, Tandil, BA(7000), Argentina
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A LifschitzLaboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), CONICET, Facultad de Ciencias Veterinarias, UNCPBA, Tandil, BA(7000), ArgentinaCorrespondence[email protected]
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Pages 227-234 | Received 03 Sep 2014, Accepted 28 Jan 2015, Published online: 18 May 2015

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A Lifschitz, C Lanusse & L Alvarez. (2017) Host pharmacokinetics and drug accumulation of anthelmintics within target helminth parasites of ruminants. New Zealand Veterinary Journal 65:4, pages 176-184.
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Articles from other publishers (16)

Gonzalo Suárez, Daniel Castells, Fernanda Imperiale, Pietro Fagiolino, Candela Canton, Carlos Lanusse & Luis Alvarez. (2023) Therapeutic advantages of the combined use of closantel and moxidectin in lambs parasitized with resistant gastrointestinal nematodes. International Journal for Parasitology: Drugs and Drug Resistance 23, pages 28-36.
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María Victoria Miró, Livio Martins Costa-Júnior, Mercedes Lloberas, Patricia Cardozo, Carlos Lanusse, Guillermo Virkel & Adrián Lifschitz. (2023) Phytochemicals in Gastrointestinal Nematode Control: Pharmacokinetic–Pharmacodynamic Evaluation of the Ivermectin plus Carvone Combination. Animals 13:8, pages 1287.
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Ming Liu, Dongsheng Ren, Xinrong Wan, Xiaona Shen, Chaoyue Zhao, Xingan, Yujie Wang, Fan Bu, Wei Liu, Zhongbing Zhang, Yulong Gao, Xiaoyan Si, Defeng Bai, Shuai Yuan, Feng Zheng, Xinru Wan, Heping Fu, Xiaodong Wu, Aihua Zheng, Qiyong Liu & Zhibin Zhang. (2022) Synergistic effects of EP ‐1 and ivermectin mixture ( iEP ‐1) to control rodents and their ectoparasites . Pest Management Science 79:2, pages 607-615.
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Sabine Specht & Ronald Kaminsky. 2022. Human and Animal Filariases. Human and Animal Filariases 345 365 .
S. Luque, M. Lloberas, P. Cardozo, G. Virkel, C. Farias, P. Viviani, C. Lanusse, L. Alvarez & A. Lifschitz. (2021) Combined moxidectin-levamisole treatment against multidrug-resistant gastrointestinal nematodes: A four-year efficacy monitoring in lambs. Veterinary Parasitology 290, pages 109362.
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D.M. Leathwick, C.M. Miller, T.S. Waghorn, H. Schwendel & A. Lifschitz. (2020) Route of administration influences the concentration of ivermectin reaching nematode parasites in the gastrointestinal tract of cattle. International Journal for Parasitology: Drugs and Drug Resistance 14, pages 152-158.
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J. A. Scare, P. Dini, J. K. Norris, A. E. Steuer, K. Scoggin, H. S. Gravatte, D. K. Howe, P. Slusarewicz & M. K. Nielsen. (2020) Ascarids exposed: a method for in vitro drug exposure and gene expression analysis of anthelmintic naïve Parascaris spp . Parasitology 147:6, pages 659-666.
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Karen E. Larsen, Adrián L. Lifschitz, Carlos E. Lanusse & Guillermo L. Virkel. (2019) In vitro and in vivo effects of chlorpyrifos and cypermethrin on blood cholinesterases in sheep. Journal of Veterinary Pharmacology and Therapeutics 42:5, pages 548-555.
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P. Viviani, A.L. Lifschitz, S.E. Luque, M.M. Lloberas, M.L. Maté, P.A. Cardozo, C.E. Lanusse & G.L. Virkel. (2019) Pharmacologic interaction between oxfendazole and triclabendazole: In vitro biotransformation and systemic exposure in sheep. Experimental Parasitology 204, pages 107718.
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Roger K. Prichard & Timothy G. Geary. (2019) Perspectives on the utility of moxidectin for the control of parasitic nematodes in the face of developing anthelmintic resistance. International Journal for Parasitology: Drugs and Drug Resistance 10, pages 69-83.
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Luis Fazzio, Laura Moreno, Walter Galvan, Candela Canton, Luis Alvarez, Nicolás Streitenberger, Ricardo Sánchez, Carlos Lanusse & Rodrigo Sanabria. (2019) Pharmacokinetic profile and anthelmintic efficacy of moxidectin administered by different doses and routes to feedlot calves. Veterinary Parasitology 266, pages 73-79.
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Yashpal S. Chhonker, Richard L. Sleightholm & Daryl J. Murry. (2018) Bioanalytical method development and validation of moxidectin in plasma by LC–MS/MS: Application to in vitro metabolism . Biomedical Chromatography 33:2.
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Carlos Lanusse, Candela Canton, Guillermo Virkel, Luis Alvarez, Livio Costa-Junior & Adrian Lifschitz. (2018) Strategies to Optimize the Efficacy of Anthelmintic Drugs in Ruminants. Trends in Parasitology 34:8, pages 664-682.
Crossref
C.E. Lanusse, L.I. Alvarez & A.L. Lifschitz. 2016. Haemonchus contortus and Haemonchosis – Past, Present and Future Trends. Haemonchus contortus and Haemonchosis – Past, Present and Future Trends 465 518 .
Lihua Jin, Rui Wang, Yanlin Zhu, Weili Zheng, Yaping Han, Fusheng Guo, Frank Bin Ye & Yong Li. (2015) Selective targeting of nuclear receptor FXR by avermectin analogues with therapeutic effects on nonalcoholic fatty liver disease. Scientific Reports 5:1.
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Luis Alvarez, Gonzalo Suarez, Laura Ceballos, Laura Moreno, Candela Canton, Adrián Lifschitz, Laura Maté, Mariana Ballent, Guillermo Virkel & Carlos Lanusse. (2015) Integrated assessment of ivermectin pharmacokinetics, efficacy against resistant Haemonchus contortus and P-glycoprotein expression in lambs treated at three different dosage levels. Veterinary Parasitology 210:1-2, pages 53-63.
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