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New Zealand Veterinary Journal Volume 65, 2017 - Issue 1
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Scientific Articles

Pharmacokinetics and estimated bioavailability of grapiprant, a novel selective prostaglandin E2 receptor antagonist, after oral administration in fasted and fed dogs

B Łebkowska-WieruszewskaDepartment of Pharmacology, University of Life Sciences, Lublin, PolandView further author information
,
G BarsottiDepartment of Veterinary Sciences, University of Pisa, Via Livornese (lato monte), San Piero a Grado, Pisa, ItalyView further author information
,
A LisowskiDepartment of Cattle Breeding and Protection of Genetic Resources, University of Life Sciences, Lublin, PolandView further author information
,
A GazzanoDepartment of Veterinary Sciences, University of Pisa, Via Livornese (lato monte), San Piero a Grado, Pisa, ItalyView further author information
,
H OwenSchool of Veterinary Science, The University of Queensland, Gatton Campus, Gatton, Queensland4343, AustraliaView further author information
&
M GiorgiDepartment of Veterinary Sciences, University of Pisa, Via Livornese (lato monte), San Piero a Grado, Pisa, ItalyCorrespondence[email protected]
View further author information
Pages 19-23 | Received 07 May 2016, Accepted 21 Sep 2016, Published online: 19 Oct 2016

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Marike Visser, Matthew J. Zaya, Charles W. Locuson, Dawn M. Boothe & Dawn A. Merritt. (2019) Comparison of predicted intrinsic hepatic clearance of 30 pharmaceuticals in canine and feline liver microsomes. Xenobiotica 49:2, pages 177-186.
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Articles from other publishers (12)

Stephanie Kleine, Chiara E. Hampton, Christopher Smith, Genevieve Bussieres, Pierre‐Yves Mulon, Reza Seddighi, Sherry Cox & Joe Smith. (2023) Pharmacokinetics of a single oral dose of grapiprant in juvenile pigs ( Sus scrofa domestica ) . Journal of Veterinary Pharmacology and Therapeutics 46:5, pages 269-275.
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Juliet M. Ross, Stephanie A. Kleine, Christopher K. Smith, Rebekah K. DeBolt, Jennifer Weisent, Emma Hendrix & Reza Seddighi. (2022) Evaluation of the perioperative analgesic effects of grapiprant compared with carprofen in dogs undergoing elective ovariohysterectomy. Journal of the American Veterinary Medical Association, pages 1-8.
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Silke L. Hoffmann, Kelsey Seminoff, Daniel S. McKemie, Philip H. Kass & Heather K. Knych. (2022) Pharmacokinetics of grapiprant and effects on TNF ‐alpha concentrations following oral administration to horses . Journal of Veterinary Pharmacology and Therapeutics 45:5, pages 467-472.
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Jennifer Halleran, Geraldine Magnin, Danielle Mzyk, Sally Venable, Robert Streeter & Johann Coetzee. (2021) Pharmacokinetics of grapiprant in goat kids at two different dosing regimens. Small Ruminant Research 205, pages 106531.
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Mark C. Heit, Katrina L. Mealey & Stephen B. King. (2021) Tolerance and Pharmacokinetics of Galliprant™ Administered Orally to Collies Homozygous for MDR1‐1Δ. Journal of Veterinary Pharmacology and Therapeutics 44:5, pages 705-713.
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Irene Sartini & Mario Giorgi. (2021) Grapiprant: A snapshot of the current knowledge. Journal of Veterinary Pharmacology and Therapeutics 44:5, pages 679-688.
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Beata Łebkowska‐Wieruszewska, Małgorzata Gbylik‐Sikorska, Anna Gajda, Irene Sartini, Andrzej Lisowski, Amnart Poapolathep & Mario Giorgi. (2021) Cebranopadol, a novel first‐in‐class drug candidate: Method validation and first exploratory pharmacokinetic study in rabbits. Journal of Veterinary Pharmacology and Therapeutics 44:4, pages 516-521.
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Sherry Cox, Carla Sommardahl, Chelsey Fortner, Rebecca Davis, Joan Bergman & Tom Doherty. (2020) Determination of grapiprant plasma and urine concentrations in horses. Veterinary Anaesthesia and Analgesia 47:5, pages 705-709.
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Heather K. Knych, Kelsey Seminoff & Dan S. McKemie. (2018) Detection and pharmacokinetics of grapiprant following oral administration to exercised Thoroughbred horses. Drug Testing and Analysis 10:8, pages 1237-1243.
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B. Lebkowska‐Wieruszewska, V. De Vito, H. Owen, A. Poapholatep & M. Giorgi. (2017) Pharmacokinetics of grapiprant, a selective EP 4 prostaglandin PGE 2 receptor antagonist, after 2 mg/kg oral and i.v. administrations in cats . Journal of Veterinary Pharmacology and Therapeutics 40:6.
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Derek Adrian, Mark Papich, Ron Baynes, Jo Murrell & B. Duncan X. Lascelles. (2017) Chronic maladaptive pain in cats: A review of current and future drug treatment options. The Veterinary Journal 230, pages 52-61.
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V. De Vito, M. Salvadori, A. Poapolathep, H. Owen, R. Rychshanova & M. Giorgi. (2016) Pharmacokinetic/pharmacodynamic evaluation of grapiprant in a carrageenan‐induced inflammatory pain model in the rabbit. Journal of Veterinary Pharmacology and Therapeutics 40:5, pages 468-475.
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