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Xenobiotica
the fate of foreign compounds in biological systems
Volume 31, 2001 - Issue 1
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Research Article

Non-enzymatic reduction of aliphatic tertiary amine N-oxides mediated by the haem moiety of cytochrome P450

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Pages 11-23 | Published online: 22 Sep 2008

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Ming Zheng, Jun Jiang, Junping Wang, Xianqing Tang, Man Ouyang & Yiqun Deng. (2011) The mechanism of enzymatic and non-enzymatic N-oxide reductive metabolism of cyadox in pig liver. Xenobiotica 41:11, pages 964-971.
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Ursula Breyer‐Pfaff. (2004) The Metabolic Fate of Amitriptyline, Nortriptyline and Amitriptylinoxide in Man. Drug Metabolism Reviews 36:3-4, pages 723-746.
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K. Takekawa, K. Sugihara, S. Kitamura & S. Ohta. (2001) Enzymatic and non-enzymatic reduction of brucine N -oxide by aldehyde oxidase and catalase. Xenobiotica 31:11, pages 769-782.
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Hailey J. Knox, Tae Wook Kim, Zhouyang Zhu & Jefferson Chan. (2018) Photophysical Tuning of N -Oxide-Based Probes Enables Ratiometric Photoacoustic Imaging of Tumor Hypoxia . ACS Chemical Biology 13:7, pages 1838-1843.
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Natalya V. Belova, Georgiy V. Girichev, Vitaliya E. Kotova, Kseniya A. Korolkova & Nguyen Hoang Trang. (2018) The molecular structure of 4-methylpyridine-N-oxide: Gas-phase electron diffraction and quantum chemical calculations. Journal of Molecular Structure 1156, pages 210-215.
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Natalya V. Belova, Nina I. Giricheva & Mikhail S. Fedorov. (2015) Substituent effect on the properties of pyridine-N-oxides. Structural Chemistry 26:5-6, pages 1459-1465.
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Cornelia Hainer, Valentina Mosienko, Stella Koutsikou, Jonathan J. Crook, Bernd Gloss, Sergey Kasparov, Bridget M. Lumb & Natalia Alenina. (2015) Beyond Gene Inactivation: Evolution of Tools for Analysis of Serotonergic Circuitry. ACS Chemical Neuroscience 6:7, pages 1116-1129.
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Heyka H. Jakobs, Danilo Froriep, Antje Havemeyer, Ralf R. Mendel, Florian Bittner & Bernd Clement. (2014) The Mitochondrial Amidoxime Reducing Component (mARC): Involvement in Metabolic Reduction of N -Oxides, Oximes and N -Hydroxyamidinohydrazones . ChemMedChem 9:10, pages 2381-2387.
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Patrik Rydberg, Martin S. Jørgensen, Thomas A. Jacobsen, Anne-Marie Jacobsen, Kim G. Madsen & Lars Olsen. (2013) Nitrogen Inversion Barriers Affect the N-Oxidation of Tertiary Alkylamines by Cytochromes P450. Angewandte Chemie International Edition 52:3, pages 993-997.
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Patrik Rydberg, Martin S. Jørgensen, Thomas A. Jacobsen, Anne‐Marie Jacobsen, Kim G. Madsen & Lars Olsen. (2012) Nitrogen Inversion Barriers Affect the N‐Oxidation of Tertiary Alkylamines by Cytochromes P450. Angewandte Chemie 125:3, pages 1027-1031.
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Stefan LöfflerJochen KörberUdo NubbemeyerKarin Fehsel. (2012) Comment on “Impaired Respiratory and Body Temperature Control Upon Acute Serotonergic Neuron Inhibition”. Science 337:6095, pages 646-646.
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Narendra B. Gowda, Gopal Krishna Rao & Ramesha A. Ramakrishna. (2010) A chemoselective deoxygenation of N-oxides by sodium borohydride–Raney nickel in water. Tetrahedron Letters 51:43, pages 5690-5693.
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N. Sh. Lebedeva, W. Zielenkiewicz, E. Utzig, Y. A. Gubarev, V. P. Andreev & Ya. P. Nizhnik. (2007) Thermal oxidative destruction of complexes of heterocyclic N-oxides with Zn(II)tetra-phenylporphyrin. Journal of Thermal Analysis and Calorimetry 91:2, pages 601-608.
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Adrian C. Nicolescu, Jeannette L. Comeau, Bruce C. Hill, Leanne L. Bedard, Takashi Takahashi, James F. Brien, William J. Racz & Thomas E. Massey. (2007) Aryl radical involvement in amiodarone-induced pulmonary toxicity: Investigation of protection by spin-trapping nitrones. Toxicology and Applied Pharmacology 220:1, pages 60-71.
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Sunil Kumar Singh, M. Srinivasa Reddy, Mangesh Mangle & K. Ravi Ganesh. (2007) Cu(I)-mediated deoxygenation of N-oxides to amines. Tetrahedron 63:1, pages 126-130.
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V. P. Andreev, Ya. P. Nizhnik, D. G. Bezruchko & A. K. Morozov. (2005) Extra Coordination of Zn-Tetraphenylporphine with Pyridine, Quinoline, and Acridine N-Oxides. Russian Journal of General Chemistry 75:8, pages 1309-1317.
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M.C. Dumasia & P. Teale. (2005) N-Deethylation and N-oxidation of etamiphylline: identification of etamiphylline-N-oxide in greyhound urine by high performance liquid chromatography–mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 36:5, pages 1085-1091.
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