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Xenobiotica
the fate of foreign compounds in biological systems
Volume 31, 2001 - Issue 2
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Research Article

Metabolism of styrene in the human liver in vitro: interindividual variation and enantioselectivity

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Pages 61-72 | Published online: 22 Sep 2008

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Read on this site (3)

LorenzR. Rhomberg, JulieE. Goodman & RobynL. Prueitt. (2013) The Weight of Evidence Does Not Support the Listing of Styrene as “Reasonably Anticipated to be a Human Carcinogen” in NTP's Twelfth Report on Carcinogens . Human and Ecological Risk Assessment: An International Journal 19:1, pages 4-27.
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Caitlin M. Brown, Brad Reisfeld & Arthur N. Mayeno. (2008) Cytochromes P450: A Structure-Based Summary of Biotransformations Using Representative Substrates. Drug Metabolism Reviews 40:1, pages 1-100.
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Pavel Vodicka, Mikko Koskinen, Alessio Naccarati, Barbara Oesch-Bartlomowicz, Ludmila Vodickova, Kari Hemminki & Franz Oesch. (2006) Styrene Metabolism, Genotoxicity, and Potential Carcinogenicity. Drug Metabolism Reviews 38:4, pages 805-853.
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Articles from other publishers (12)

F. Oesch, E. Fabian & Robert Landsiedel. (2019) Xenobiotica-metabolizing enzymes in the lung of experimental animals, man and in human lung models. Archives of Toxicology 93:12, pages 3419-3489.
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Samuel D. Munday, Shaghayegh Dezvarei, Ian C.‐K. Lau & Stephen G. Bell. (2017) Examination of Selectivity in the Oxidation of ortho ‐ and meta ‐Disubstituted Benzenes by CYP102A1 (P450 Bm3) Variants . ChemCatChem 9:13, pages 2512-2522.
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Slobodan Rendic & F. Peter Guengerich. (2012) Contributions of Human Enzymes in Carcinogen Metabolism. Chemical Research in Toxicology 25:7, pages 1316-1383.
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Ans Punt, Suzanne M. Jeurissen, Marelle G. Boersma, Thierry Delatour, Gabriele Scholz, Benoît Schilter, Peter J. van Bladeren & Ivonne M. C. M. Rietjens. (2010) Evaluation of Human Interindividual Variation in Bioactivation of Estragole Using Physiologically Based Biokinetic Modeling. Toxicological Sciences 113:2, pages 337-348.
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Shuijie Shen, Fan Zhang, Su Zeng & Jiang Zheng. (2009) An approach based on liquid chromatography/electrospray ionization–mass spectrometry to detect diol metabolites as biomarkers of exposure to styrene and 1,3-butadiene. Analytical Biochemistry 386:2, pages 186-193.
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José Rueff, João P. Teixeira, Luís Silva Santos & Jorge Francisco Gaspar. (2009) Genetic effects and biotoxicity monitoring of occupational styrene exposure. Clinica Chimica Acta 399:1-2, pages 8-23.
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Leigh M. Henderson & Günter Speit. (2005) Review of the genotoxicity of styrene in humans. Mutation Research/Reviews in Mutation Research 589:3, pages 158-191.
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Reiko Kishi, Fumihiro Sata, Yoko Katakura, Rui‐Sheng Wang & Tamie Nakajima. (2005) Effects of Pregnancy, Age and Sex in the Metabolism of Styrene in Rat Liver in Relation to the Regulation of Cytochrome P450 Enzymes. Journal of Occupational Health 47:1, pages 49-55.
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Paola Manini, Luca Buzio, Roberta Andreoli, Matteo Goldoni, Enrico Bergamaschi, Marek Jakubowski, Pavel Vodicka, Ari Hirvonen & Antonio Mutti. (2003) Assessment of biotransformation of the arene moiety of styrene in volunteers and occupationally exposed workers. Toxicology and Applied Pharmacology 189:3, pages 160-169.
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Carmelita Estavillo, Zhongqing Lu, Ingela Jansson, John B. Schenkman & James F. Rusling. (2003) Epoxidation of styrene by human cyt P450 1A2 by thin film electrolysis and peroxide activation compared to solution reactions. Biophysical Chemistry 104:1, pages 291-296.
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David F. V. Lewis, Craig Sams & George D. Loizou. (2003) A quantitative structure–activity relationship analysis on a series of alkyl benzenes metabolized by human cytochrome P450 2E1. Journal of Biochemical and Molecular Toxicology 17:1, pages 47-52.
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Vincent Haufroid, Marek Jakubowski, Beata Janasik, Danuta Ligocka, Jean-Pierre Buchet, Enrico Bergamaschi, Paola Manini, Antonio Mutti, Sergio Ghittori, Michael Arand, Nina Hangen, Franz Oesch, Ari Hirvonen & Dominique Lison. (2002) Interest of genotyping and phenotyping of drug-metabolizing enzymes for the interpretation of biological monitoring of exposure to styrene. Pharmacogenetics 12:9, pages 691-702.
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