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Xenobiotica
the fate of foreign compounds in biological systems
Volume 30, 2000 - Issue 5
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Research Article

Pharmacokinetics of the anticoagulant 14C-DX-9065a in the healthy male volunteer after a single intravenous dose

N. Murayama Drug Metabolism and Analytical Chemistry Research Laboratory, Daiichi Pharmaceutical Co., Ltd, 16-13, Kitakasai 1-chome, Edogawa-ku, Tokyo 134-8630, Japan
,
H. McMahon Drug Metabolism and Analytical Chemistry Research Laboratory, Daiichi Pharmaceutical Co., Ltd, 16-13, Kitakasai 1-chome, Edogawa-ku, Tokyo 134-8630, Japan
,
C. G. Young Drug Metabolism and Analytical Chemistry Research Laboratory, Daiichi Pharmaceutical Co., Ltd, 16-13, Kitakasai 1-chome, Edogawa-ku, Tokyo 134-8630, Japan
,
N. W. McCracken Drug Metabolism and Analytical Chemistry Research Laboratory, Daiichi Pharmaceutical Co., Ltd, 16-13, Kitakasai 1-chome, Edogawa-ku, Tokyo 134-8630, Japan
,
Y. Okamura Drug Metabolism and Analytical Chemistry Research Laboratory, Daiichi Pharmaceutical Co., Ltd, 16-13, Kitakasai 1-chome, Edogawa-ku, Tokyo 134-8630, Japan
,
H. Hakusui Drug Metabolism and Analytical Chemistry Research Laboratory, Daiichi Pharmaceutical Co., Ltd, 16-13, Kitakasai 1-chome, Edogawa-ku, Tokyo 134-8630, Japan
&
M. Tanaka Drug Metabolism and Analytical Chemistry Research Laboratory, Daiichi Pharmaceutical Co., Ltd, 16-13, Kitakasai 1-chome, Edogawa-ku, Tokyo 134-8630, Japan
 show all
Pages 515-521 | Published online: 22 Sep 2008

Citations (13)

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Sarah J. Roffey, R. Scott Obach, Jenny I. Gedge & Dennis A. Smith. (2007) What is the Objective of the Mass Balance Study? A Retrospective Analysis of Data in Animal and Human Excretion Studies Employing Radiolabeled Drugs. Drug Metabolism Reviews 39:1, pages 17-43.
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Johannes Ruef & Hugo A Katus. (2003) New antithrombotic drugs on the horizon. Expert Opinion on Investigational Drugs 12:5, pages 781-797.
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Articles from other publishers (11)

Yoshimine Fujii. (2017) Approaches to improving the oral bioavailabity of the low-permeability compound DX-9065, and species differences in bioavailability in preclinical and clinical studies低膜透過性化合物DX-9065の経口吸収改善と種差. Drug Delivery System 32:5, pages 381-388.
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Yoshimine Fujii, Taro Kanamaru, Hiroshi Kikuchi, Shinji Yamashita & Shinji Sakuma. (2011) Enteric-coated tablets improve oral bioavailability of DX-9065, a novel anticoagulant. European Journal of Pharmaceutical Sciences 42:4, pages 392-399.
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. 2006. Wiley Handbook of Current and Emerging Drug Therapies. Wiley Handbook of Current and Emerging Drug Therapies.
Nobuyuki Murayama, Minoru Nakaoka & Kenichi Sudo. (2006) Contribution of lysosomes to concentrative uptake of DX-9065a into rat liver. Journal of Pharmaceutical Sciences 95:8, pages 1763-1770.
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Paul P. Dobesh, Karissa Kim & Zachary Stacy. (2016) The Future of Anticoagulation. Journal of Pharmacy Practice 17:5, pages 370-384.
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Yuji Mano, Takuya Sonoda, Eiji Nakamura, Takashi Usui & Hidetaka Kamimura. (2004) Absorption, distribution, metabolism and excretion of YM466, a novel factor Xa inhibitor, in rats. Biopharmaceutics & Drug Disposition 25:6, pages 253-260.
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Yuji Mano, Takashi Usui & Hidetaka Kamimura. (2004) Pharmacokinetics of YM466, a new factor Xa inhibitor, in rats and dogs. European Journal of Drug Metabolism and Pharmacokinetics 29:1, pages 7-13.
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Brigitte Kaiser. (2006) DX‐9065a, a Direct Inhibitor of Factor Xa. Cardiovascular Drug Reviews 21:2, pages 91-104.
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Stephan Moll & Harold R. Roberts. (2002) Overview of anticoagulant drugs for the future. Seminars in Hematology 39:3, pages 145-157.
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Christopher K. DykeRichard C. BeckerNeal S. KleimanJudith S. HochmanEdwin G. BovillA. Michael LincoffGary GerstenblithVladimir DzavikLaura H. GardnerVic HasselbladLinda A. ZillmanYoshimasa ShimotoThomas L. RobertsonSatoshi KunitadaPaul W. ArmstrongRobert A. Harrington. (2002) First Experience With Direct Factor Xa Inhibition in Patients With Stable Coronary Disease. Circulation 105:20, pages 2385-2391.
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Philip E.J. Sanderson. 2001. 79 88 .

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