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Xenobiotica
the fate of foreign compounds in biological systems
Volume 30, 2000 - Issue 1
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Research Article

In vitro inhibitory effects of troglitazone and its metabolites on drug oxidation activities of human cytochrome P450 enzymes: comparison with pioglitazone and rosiglitazone

Pages 61-70 | Published online: 27 Aug 2009

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Justin D Lutz & Nina Isoherranen. (2012) In vitro-to-in vivo predictions of drug–drug interactions involving multiple reversible inhibitors. Expert Opinion on Drug Metabolism & Toxicology 8:4, pages 449-466.
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Shu-Feng Zhou, Jun-Ping Liu & Balram Chowbay. (2009) Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metabolism Reviews 41:2, pages 89-295.
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Thomas Forst & Andreas Pfützner. (2007) Fixed-dose combination of pioglitazone and glimepiride in the treatment of Type 2 diabetes mellitus. Expert Review of Endocrinology & Metabolism 2:3, pages 303-312.
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James J Cali, Dongping Ma, Mary Sobol, Daniel J Simpson, Susan Frackman, Troy D Good, William J Daily & David Liu. (2006) Luminogenic cytochrome P450 assays. Expert Opinion on Drug Metabolism & Toxicology 2:4, pages 629-645.
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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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George Valsamakis & Sudhesh Kumar. (2000) Insulin action enhancers for the management of Type 2 diabetes mellitus. Expert Opinion on Pharmacotherapy 1:7, pages 1413-1421.
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Shankar S & Suneetha Vuppu. (2020) In vitro drug metabolism and pharmacokinetics of a novel thiazolidinedione derivative, a potential anticancer compound. Journal of Pharmaceutical and Biomedical Analysis 179, pages 113000.
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Kenta Haraya, Motohiro Kato, Koji Chiba & Yuichi Sugiyama. (2017) Prediction of inter-individual variability on the pharmacokinetics of CYP2C8 substrates in human. Drug Metabolism and Pharmacokinetics 32:6, pages 277-285.
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Janne T. Backman, Anne M. Filppula, Mikko Niemi & Pertti J. Neuvonen. (2015) Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions. Pharmacological Reviews 68:1, pages 168-241.
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Mona Yousofshahi, Sara Manteiga, Charmian Wu, Kyongbum Lee & Soha Hassoun. (2015) PROXIMAL: a method for Prediction of Xenobiotic Metabolism. BMC Systems Biology 9:1.
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Terra Arnason & Troy Harkness. (2015) Development, Maintenance, and Reversal of Multiple Drug Resistance: At the Crossroads of TFPI1, ABC Transporters, and HIF1. Cancers 7:4, pages 2063-2082.
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Shinya Hosaka, Norie Murayama, Masahiro Satsukawa, Shotaro Uehara, Makiko Shimizu, Kazuhide Iwasaki, Shunsuke Iwano, Yasuhiro Uno & Hiroshi Yamazaki. (2015) Comprehensive Evaluation for Substrate Selectivity of Cynomolgus Monkey Cytochrome P450 2C9, a New Efavirenz Oxidase. Drug Metabolism and Disposition 43:7, pages 1119-1122.
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Francesco Rua, Giovanna Di Nardo, Sheila J. Sadeghi & Gianfranco Gilardi. (2012) Toward reduction in animal sacrifice for drugs: Molecular modeling of Macaca fascicularis P450 2C20 for virtual screening of Homo sapiens P450 2C8 substrates . Biotechnology and Applied Biochemistry 59:6, pages 479-489.
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Ki Young Lee. (2011) Use of Oral Hypoglycemic Agents in Type 2 Diabetic Patients with Hepatic Dysfunction. Journal of Korean Diabetes 12:4, pages 190.
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G.F. Davies, A.R. Ross, T.G. Arnason, B.H.J. Juurlink & T.A.A. Harkness. (2010) Troglitazone inhibits histone deacetylase activity in breast cancer cells. Cancer Letters 288:2, pages 236-250.
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Jing Zi, Duan Liu, Pingping Ma, He Huang, Juanli Zhu, Dongqing Wei, Jin Yang & Chao Chen. (2010) Effects of CYP2C9*3 and CYP2C9* 13 on Diclofenac Metabolism and Inhibition-based Drug-Drug Interactions. Drug Metabolism and Pharmacokinetics 25:4, pages 343-350.
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Susan Kadlubar & Fred F. Kadlubar. 2010. Enzyme- and Transporter-Based Drug-Drug Interactions. Enzyme- and Transporter-Based Drug-Drug Interactions 3 25 .
Eugen Muschler, Jawahar Lal, Alexander Jetter, Anke Rattay, Ulrich Zanger, Gregor Zadoyan, Uwe Fuhr & Julia Kirchheiner. (2009) The Role of Human CYP2C8 and CYP2C9 Variants in Pioglitazone Metabolism In Vitro . Basic & Clinical Pharmacology & Toxicology 105:6, pages 374-379.
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Julia KirchheinerIngolf MeinekeUwe FuhrCristina Rodríguez-AntonaElena LebedevaJürgen Brockmöller. (2008) Impact of genetic polymorphisms in CYP2C8 and rosiglitazone intake on the urinary excretion of dihydroxyeicosatrienoic acids . Pharmacogenomics 9:3, pages 277-288.
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Dan Rock, Jan Wahlstrom & Larry Wienkers. 2008. Antitargets. Antitargets 195 246 .
Andr?? J Scheen. (2007) Pharmacokinetic Interactions with Thiazolidinediones. Clinical Pharmacokinetics 46:1, pages 1-12.
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Lauri I. Kajosaari, Tiina Jaakkola, Pertti J. Neuvonen & Janne T. Backman. (2006) Pioglitazone, an in vitro inhibitor of CYP2C8 and CYP3A4, does not increase the plasma concentrations of the CYP2C8 and CYP3A4 substrate repaglinide. European Journal of Clinical Pharmacology 62:3, pages 217-223.
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Grazyna Sobal, E J Menzel & H Sinzinger. (2005) Troglitazone Inhibits Long-Term Glycation and Oxidation of Low-Density Lipoprotein. Journal of Cardiovascular Pharmacology 46:5, pages 672-680.
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Andr?? J Scheen. (2005) Drug Interactions of Clinical Importance with Antihyperglycaemic Agents. Drug Safety 28:7, pages 601-631.
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Chie Emoto, Shigeo Murase, Yasufusa Sawada & Kazuhide Iwasaki. (2005) In Vitro Inhibitory Effect of 1-Aminobenzotriazole on Drug Oxidations in Human Liver Microsomes: a Comparison with SKF-525A. Drug Metabolism and Pharmacokinetics 20:5, pages 351-357.
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Chikako Ishikawa, Hiroshi Ozaki, Toshiaki Nakajima, Toshihiro Ishii, Saburo Kanai, Saeko Anjo, Kohji Shirai & Ituro Inoue. (2004) A frameshift variant of CYP2C8 was identified in a patient who suffered from rhabdomyolysis after administration of cerivastatin. Journal of Human Genetics 49:10, pages 582-585.
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Jun Ueyama, Kiyoyuki Kitaichi, Masayuki Nadai, Mitsunori Iwase, Nao Tomyo, Hiroaki Kanazawa, Ryujiro Suzuki, Kenji Takagi, Kenzo Takagi & Takaaki Hasegawa. (2004) Effect of pioglitazone on endotoxin-induced decreases in hepatic drug-metabolizing enzyme activity and expression of CYP3A2 and CYP2C11. European Journal of Pharmacology 498:1-3, pages 257-265.
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Keith G Tolman & Jane Chandramouli. (2003) Hepatotoxicity of the thiazolidinediones. Clinics in Liver Disease 7:2, pages 369-379.
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Jasminder Sahi, Christopher B. Black, Geraldine A. Hamilton, Xianxian Zheng, Summer Jolley, Kelly A. Rose, Darryl Gilbert, Edward L. LeCluyse & Michael W. Sinz. (2003) Comparative Effects of Thiazolidinediones on in Vitro P450 Enzyme Induction and Inhibition. Drug Metabolism and Disposition 31:4, pages 439-446.
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Agneta Hilding, Kerstin Hall, Josefin Skogsberg, Ewa Ehrenborg & Moira S Lewitt. (2003) Troglitazone stimulates IGF-binding protein-1 by a PPARγ-independent mechanism. Biochemical and Biophysical Research Communications 303:2, pages 693-699.
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Padma Kumar Narayanan, Timothy Hart, Fiona Elcock, Cindy Zhang, Laura Hahn, David McFarland, Lester Schwartz, D. Gwyn Morgan & Peter Bugelski. (2003) Troglitazone-induced intracellular oxidative stress in rat hepatoma cells: A flow cytometric assessment. Cytometry 52A:1, pages 28-35.
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Chie Emoto, Shigeo Murase, Yasufusa Sawada, Barry C. Jones & Kazuhide Iwasaki. (2003) In Vitro Inhibitory Effect of 1-Aminobenzotriazole on Drug Oxidations Catalyzed by Human Cytochrome P450 Enzymes: A Comparison with SKF-525A and Ketoconazole. Drug Metabolism and Pharmacokinetics 18:5, pages 287-295.
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Sandra N. Nowak, David J. Edwards, Anthony Clarke, Gail D. Anderson & Linda A. Jaber. (2013) Pioglitazone: Effect on CYP3A4 Activity. The Journal of Clinical Pharmacology 42:12, pages 1299-1302.
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Yuichiro Watanabe, Miki Nakajima & Tsuyoshi Yokoi. (2002) Troglitazone Glucuronidation in Human Liver and Intestine Microsomes: High Catalytic Activity of UGT1A8 and UGT1A10. Drug Metabolism and Disposition 30:12, pages 1462-1469.
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Saileta Prabhu, Andrew Fackett, Scott Lloyd, Holly A McClellan, Chris M Terrell, Paul M Silber & Albert P Li. (2002) Identification of glutathione conjugates of troglitazone in human hepatocytes. Chemico-Biological Interactions 142:1-2, pages 83-97.
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David R. Owens. (2002) Thiazolidinediones. Clinical Drug Investigation 22:8, pages 485-505.
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Loren D. Grossman. (2002) New Solutions for Type 2 Diabetes Mellitus. PharmacoEconomics 20:Supplement 1, pages 1-9.
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Antona J. Wagstaff & Karen L. Goa. (2002) Rosiglitazone. Drugs 62:12, pages 1805-1837.
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Paolo Brunetti. (2016) Pioglitazone — current profile. The British Journal of Diabetes & Vascular Disease 2:1_suppl, pages S18-S23.
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George Steiner. (2001) The use of fibrates and of statins in preventing atherosclerosis in diabetes. Current Opinion in Lipidology 12:6, pages 611-617.
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Thomayant Prueksaritanont, José M. Vega, Jamie Zhao, Kathleen Gagliano, Olga Kuznetsova, Bret Musser, Raju D. Amin, Lida Liu, Brad A. Roadcap, Stacy Dilzer, K. C. Lasseter & J. Douglas Rogers. (2001) Interactions between Simvastatin and Troglitazone or Pioglitazone in Healthy Subjects. The Journal of Clinical Pharmacology 41:5, pages 573-581.
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Peter S. Gillies & Christopher J. Dunn. (2000) Pioglitazone. Drugs 60:2, pages 333-343.
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