Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 30, 2000 - Issue 6
270
Views
81
CrossRef citations to date
0
Altmetric
Research Article

Evidence for propofol hydroxylation by cytochrome P4502B11 in canine liver microsomes: breed and gender differences

, , &
Pages 575-588 | Published online: 22 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Yasuhiro Uno, Yutaro Noda, Saho Morikuni, Norie Murayama & Hiroshi Yamazaki. (2023) Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs. Xenobiotica 53:3, pages 140-148.
Read now
Gaku Okamatsu, Tetsuya Komatsu, Yuka Ono, Hiroki Inoue, Tsuyoshi Uchide, Takenori Onaga, Daiji Endoh, Takio Kitazawa, Takeo Hiraga, Yasuhiro Uno & Hiroki Teraoka. (2017) Characterization of feline cytochrome P450 2B6. Xenobiotica 47:2, pages 93-102.
Read now
Marilyn N. Martinez, Leposava Antonovic, Michael Court, Mauro Dacasto, Johanna Fink-Gremmels, Butch Kukanich, Chuck Locuson, Katrina Mealey, Michael J. Myers & Lauren Trepanier. (2013) Challenges in exploring the cytochrome P450 system as a source of variation in canine drug pharmacokinetics. Drug Metabolism Reviews 45:2, pages 218-230.
Read now
K. L. Mealey, M. Jabbes, E. Spencer & J. M. Akey. (2008) Differential expression of and mRNAs in canine liver and intestine. Xenobiotica 38:10, pages 1305-1312.
Read now

Articles from other publishers (77)

Jennifer E. Carter. 2024. Pharmacology in Veterinary Anesthesia and Analgesia. Pharmacology in Veterinary Anesthesia and Analgesia 106 122 .
Jeffrey Lakritz. 2024. Pharmacology in Veterinary Anesthesia and Analgesia. Pharmacology in Veterinary Anesthesia and Analgesia 13 30 .
Stephanie E. Martinez, Amit V. Pandey, Tania E. Perez Jimenez, Zhaohui Zhu & Michael H. Court. (2024) Pharmacogenomics of poor drug metabolism in greyhounds: Canine P450 oxidoreductase genetic variation, breed heterogeneity, and functional characterization. PLOS ONE 19:2, pages e0297191.
Crossref
Ayushi Vaidhya, Kanika Ghildiyal, Divya Rajawat, Sonali Sonejita Nayak, Subhashree Parida & Manjit Panigrahi. (2023) Relevance of pharmacogenetics and pharmacogenomics in veterinary clinical practice: A review. Animal Genetics 55:1, pages 3-19.
Crossref
Chiara E. Hampton, Anderson da Cunha, Amber Desselle, Patricia Queiroz-Williams & Erik H. Hofmeister. (2023) The effect of age on the induction dose of propofol for general anesthesia in dogs. PLOS ONE 18:7, pages e0288088.
Crossref
Yasuhiro Uno, Shiori Jikuya, Yutaro Noda, Norie Murayama & Hiroshi Yamazaki. (2022) A Comprehensive Investigation of Dog Cytochromes P450 3A (CYP3A) Reveals A Functional Role of Newly Identified CYP3A98 in Small Intestine . Drug Metabolism and Disposition, pages DMD-AR-2021-000749.
Crossref
Matthew E. Tonero, Zhong Li & Jennifer M. Reinhart. (2022) Cytochrome P450 reaction phenotyping of itraconazole hydroxylation in the dog . Journal of Veterinary Pharmacology and Therapeutics 45:3, pages 255-264.
Crossref
Tania Perez Jimenez. 2022. Canine and Feline Anesthesia and Co‐Existing Disease. Canine and Feline Anesthesia and Co‐Existing Disease 345 358 .
Mary Emily Tonge. (2021) CPD article: Sedation and general anaesthesia of the portosystemic shunt patient. Companion Animal 26:5, pages 1-9.
Crossref
Emre Karakus, Clarissa Prinzinger, Silke Leiting & Joachim Geyer. (2021) Sequencing of the Canine Cytochrome P450 CYP2C41 Gene and Genotyping of Its Polymorphic Occurrence in 36 Dog Breeds. Frontiers in Veterinary Science 8.
Crossref
Joachim Geyer. (2021) Personalisierte Medizin in der Pharmakotherapie: Wie weit sind wir in der Veterinärmedizin?. kleintier konkret 24:02, pages 20-30.
Crossref
L.S. Lautz, M.Z. Jeddi, F. Girolami, C. Nebbia & J.L.C.M. Dorne. (2021) Metabolism and pharmacokinetics of pharmaceuticals in cats (Felix sylvestris catus) and implications for the risk assessment of feed additives and contaminants. Toxicology Letters 338, pages 114-127.
Crossref
Bassam K. Kudhair, Noralhuda N. Alabid, Asghar Taheri-Kafrani & Inam J. Lafta. (2020) Correlation of GSTP1 gene variants of male Iraqi waterpipe (Hookah) tobacco smokers and the risk of lung cancer. Molecular Biology Reports 47:4, pages 2677-2684.
Crossref
Stephanie E. Martinez, Marie C. Andresen, Zhaohui Zhu, Ioannis Papageorgiou & Michael H. Court. (2020) Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization. Scientific Reports 10:1.
Crossref
Alessio Pierini, Irene Sartini, Mario Giorgi, Beata Łebkowska-Wieruszewska, Andrzej Lisowski, Amnart Poapolathep & Veronica Marchetti. (2020) Pharmacokinetics of thalidomide in dogs: can feeding affect it? A preliminary study. Journal of Veterinary Science 21:5.
Crossref
Kraisiri Khidkhan, Hazuki Mizukawa, Yoshinori Ikenaka, Shouta M.M. Nakayama, Kei Nomiyama, Nozomu Yokoyama, Osamu Ichii, Wageh Sobhy Darwish, Mitsuyoshi Takiguchi, Shinsuke Tanabe & Mayumi Ishizuka. (2019) Tissue distribution and characterization of feline cytochrome P450 genes related to polychlorinated biphenyl exposure. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 226, pages 108613.
Crossref
Stephanie E. Martinez, Jian Shi, Hao-Jie Zhu, Tania E. Perez Jimenez, Zhaohui Zhu & Michael H. Court. (2019) Absolute Quantitation of Drug-Metabolizing Cytochrome P450 Enzymes and Accessory Proteins in Dog Liver Microsomes Using Label-Free Standard-Free Analysis Reveals Interbreed Variability. Drug Metabolism and Disposition 47:11, pages 1314-1324.
Crossref
J.-P. Haberer. (2019) Propofol: metabolismo y farmacocinética. EMC - Anestesia-Reanimación 45:3, pages 1-16.
Crossref
J.-P. Haberer. (2019) Propofol: metabolismo e farmacocinetica. EMC - Anestesia-Rianimazione 24:3, pages 1-15.
Crossref
Katrina L. Mealey, Stephanie E. Martinez, Nicolas F. Villarino & Michael H. Court. (2019) Personalized medicine: going to the dogs?. Human Genetics 138:5, pages 467-481.
Crossref
Katrina L. Mealey. 2019. Pharmacotherapeutics for Veterinary Dispensing. Pharmacotherapeutics for Veterinary Dispensing 95 107 .
Deirdre P. Campion & Fiona J. Dowell. (2019) Translating Pharmacogenetics and Pharmacogenomics to the Clinic: Progress in Human and Veterinary Medicine. Frontiers in Veterinary Science 6.
Crossref
Tania E. Perez Jimenez, Katrina L. Mealey, Darren Schnider, Tamara L. Grubb, Stephen A. Greene & Michael H. Court. (2018) Identification of canine cytochrome P‐450s ( CYP s) metabolizing the tramadol (+)‐M1 and (+)‐M2 metabolites to the tramadol (+)‐M5 metabolite in dog liver microsomes . Journal of Veterinary Pharmacology and Therapeutics 41:6, pages 815-824.
Crossref
Marilyn N. Martinez, Michael H. Court, Johanna Fink‐Gremmels & Katrina L. Mealey. (2018) Population variability in animal health: Influence on dose–exposure–response relationships: Part I: Drug metabolism and transporter systems. Journal of Veterinary Pharmacology and Therapeutics 41:4.
Crossref
K. Kongara. (2017) Pharmacogenetics of opioid analgesics in dogs. Journal of Veterinary Pharmacology and Therapeutics 41:2, pages 195-204.
Crossref
M. Visser, K. Weber, G. Rincon & D. Merritt. (2017) Use of RNA ‐seq to determine variation in canine cytochrome P450 mRNA expression between blood, liver, lung, kidney and duodenum in healthy beagles . Journal of Veterinary Pharmacology and Therapeutics 40:6, pages 583-590.
Crossref
Thierry Beths. 2017. Total Intravenous Anesthesia and Target Controlled Infusions. Total Intravenous Anesthesia and Target Controlled Infusions 589 618 .
Tania E. Perez, Katrina L. Mealey, Tamara L. Grubb, Stephen A. Greene & Michael H. Court. (2016) Tramadol Metabolism to O -Desmethyl Tramadol (M1) and N -Desmethyl Tramadol (M2) by Dog Liver Microsomes: Species Comparison and Identification of Responsible Canine Cytochrome P450s . Drug Metabolism and Disposition 44:12, pages 1963-1972.
Crossref
S. Achanta & L. K. Maxwell. (2014) Reaction phenotyping of vinblastine metabolism in dogs. Veterinary and Comparative Oncology 14:2, pages 161-169.
Crossref
J.T. Martinez, L.K. Rogers, C. Kellogg, M.C. Iazbik, C.G. Couto, B.M. Pressler, T.M. Hoepf & M.J. Radin. (2016) Plasma Vasoprotective Eicosanoid Concentrations in Healthy Greyhounds and Non‐Greyhound Dogs. Journal of Veterinary Internal Medicine 30:2, pages 583-590.
Crossref
A. Costa, R. K. Sellon, M. Court, N. S. Burke & K. L. Mealey. (2015) Polymorphisms in the canine glucocorticoid receptor alpha gene ( NR 3C1α) . Journal of Veterinary Pharmacology and Therapeutics 39:1, pages 16-21.
Crossref
Butch KuKanich & Kate KuKanich. (2015) Chloramphenicol significantly affects the pharmacokinetics of oral methadone in Greyhound dogs. Veterinary Anaesthesia and Analgesia 42:6, pages 597-607.
Crossref
Jessica Lawrence, David Cameron & David Argyle. (2015) Species differences in tumour responses to cancer chemotherapy. Philosophical Transactions of the Royal Society B: Biological Sciences 370:1673, pages 20140233.
Crossref
Ted Whittem, Thierry Beths & Sébastien H. Bauquier. 2015. Veterinary Anesthesia and Analgesia. Veterinary Anesthesia and Analgesia 145 177 .
Richard M. Bednarski. 2015. Veterinary Anesthesia and Analgesia. Veterinary Anesthesia and Analgesia 817 826 .
Peter J. Pascoe & Bruno H. Pypendop. 2015. Veterinary Anesthesia and Analgesia. Veterinary Anesthesia and Analgesia 721 730 .
Stephanie H. Berry. 2015. Veterinary Anesthesia and Analgesia. Veterinary Anesthesia and Analgesia 277 296 .
Yu-Ting Tai, Yi-Ling Lin, Chia-Chen Chang, Yih-Giun Cherng, Ming-Jaw Don & Ruei-Ming Chen. (2015) Ring-Oxidative Biotransformation and Drug Interactions of Propofol in the Livers of Rats. BioMed Research International 2015, pages 1-11.
Crossref
Stephanie Kleine, Erik Hofmeister & Katrina Egan. (2014) Multivariable analysis of anesthetic factors associated with time to extubation in dogs. Research in Veterinary Science 97:3, pages 592-596.
Crossref
Ikuo Yamamiya, Kunihiro Yoshisue, Yuji Ishii, Hideyuki Yamada & Ken-ichiro Yoshida. (2014) Species variation in the enantioselective metabolism of tegafur to 5-fluorouracil among rats, dogs and monkeys. Journal of Pharmacy and Pharmacology 66:12, pages 1686-1697.
Crossref
. (2014) Scientific Opinion on Chloramphenicol in food and feed. EFSA Journal 12:11.
Crossref
Sanja Modric. 2014. Strategies for Reducing Drug and Chemical Residues in Food Animals. Strategies for Reducing Drug and Chemical Residues in Food Animals 9 33 .
. 2014. Veterinary Anaesthesia. Veterinary Anaesthesia 135 153 .
Michael H. Court. (2013) Feline Drug Metabolism and Disposition. Veterinary Clinics of North America: Small Animal Practice 43:5, pages 1039-1054.
Crossref
Michael H. Court. (2013) Canine Cytochrome P-450 Pharmacogenetics. Veterinary Clinics of North America: Small Animal Practice 43:5, pages 1027-1038.
Crossref
Lauren A. Trepanier. (2013) Applying Pharmacokinetics to Veterinary Clinical Practice. Veterinary Clinics of North America: Small Animal Practice 43:5, pages 1013-1026.
Crossref
B. KuKANICH & J. L. NAUSS. (2011) Pharmacokinetics of the cytochrome P‐450 substrates phenytoin, theophylline, and diazepam in healthy Greyhound dogs. Journal of Veterinary Pharmacology and Therapeutics 35:3, pages 275-281.
Crossref
Carolina P Jiménez, Alessandra Mathis, Sandra S Mora, David Brodbelt & Hatim Alibhai. (2012) Evaluation of the quality of the recovery after administration of propofol or alfaxalone for induction of anaesthesia in dogs anaesthetized for magnetic resonance imaging. Veterinary Anaesthesia and Analgesia 39:2, pages 151-159.
Crossref
Carlo Nebbia. 2012. Veterinary Toxicology. Veterinary Toxicology 48 61 .
Gheorghe DucaGheorghe Duca. 2012. Homogeneous Catalysis with Metal Complexes. Homogeneous Catalysis with Metal Complexes 123 260 .
Eileen S. Hackett & Daniel L. Gustafson. (2011) Alterations of Drug Metabolism in Critically Ill Animals. Veterinary Clinics of North America: Small Animal Practice 41:4, pages 805-815.
Crossref
S. MODRIC & M. MARTINEZ. (2011) Patient variation in veterinary medicine - Part II - Influence of physiological variables. Journal of Veterinary Pharmacology and Therapeutics 34:3, pages 209-223.
Crossref
M. M. WILLIAMS, E. G. DAVIS & B. KuKANICH. (2011) Pharmacokinetics of oral terbinafine in horses and Greyhound dogs. Journal of Veterinary Pharmacology and Therapeutics 34:3, pages 232-237.
Crossref
Butch KuKanich, Kate S KuKanich & Jessica R Rodriguez. (2011) The effects of concurrent administration of cytochrome P-450 inhibitors on the pharmacokinetics of oral methadone in healthy dogs. Veterinary Anaesthesia and Analgesia 38:3, pages 224-230.
Crossref
Maja Kirkegaard, Christian Sonne, Rune Dietz, Robert J. Letcher, Asger L. Jensen, Signe Stige Hansen, Bjørn Munro Jenssen & Philippe Grandjean. (2011) Alterations in thyroid hormone status in Greenland sledge dogs exposed to whale blubber contaminated with organohalogen compounds. Ecotoxicology and Environmental Safety 74:1, pages 157-163.
Crossref
Marie‐Claude Duhamel, Éric Troncy & Francis Beaudry. (2010) Metabolic stability and determination of cytochrome P450 isoenzymes' contribution to the metabolism of medetomidine in dog liver microsomes. Biomedical Chromatography 24:8, pages 868-877.
Crossref
M. F. YANCEY, D. A. MERRITT, J. A. WHITE, S. A. MARSH & C. W. LOCUSON. (2010) Distribution, metabolism, and excretion of toceranib phosphate (Palladia™, SU11654), a novel tyrosine kinase inhibitor, in dogs. Journal of Veterinary Pharmacology and Therapeutics 33:2, pages 154-161.
Crossref
M. T. BARATTA, M. J. ZAYA, J. A. WHITE & C. W. LOCUSON. (2010) Canine CYP2B11 metabolizes and is inhibited by anesthetic agents often co-administered in dogs. Journal of Veterinary Pharmacology and Therapeutics 33:1, pages 50-55.
Crossref
Carrie M. Mosher & Michael H. Court. 2010. Comparative and Veterinary Pharmacology. Comparative and Veterinary Pharmacology 49 77 .
K. PASLOSKE, B. SAUER, N. PERKINS & T. WHITTEM. (2009) Plasma pharmacokinetics of alfaxalone in both premedicated and unpremedicated Greyhound dogs after single, intravenous administration of Alfaxan ® at a clinical dose . Journal of Veterinary Pharmacology and Therapeutics 32:5, pages 510-513.
Crossref
David J. Waxman & Minita G. Holloway. (2009) Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes. Molecular Pharmacology 76:2, pages 215-228.
Crossref
Jonathan Verreault, Robert J. Letcher, Christian Sonne & Rune Dietz. (2009) In vitro metabolism of polychlorinated biphenyls and cytochrome P450 monooxygenase activities in dietary-exposed Greenland sledge dogs. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 150:1, pages 91-100.
Crossref
Jonathan Verreault, France Maisonneuve, Rune Dietz, Christian Sonne & Robert J. Letcher. (2009) Comparative hepatic activity of xenobiotic‐metabolizing enzymes and concentrations of organohalogens and their hydroxylated analogues in captive greenland sledge dogs ( Canis familiaris ) . Environmental Toxicology and Chemistry 28:1, pages 162-172.
Crossref
Katrina L. Mealey & Kathryn M. Meurs. (2008) Breed distribution of the ABCB1-1Δ (multidrug sensitivity) polymorphism among dogs undergoing ABCB1 genotyping. Journal of the American Veterinary Medical Association 233:6, pages 921-924.
Crossref
Divesh Aidasani, Matthew J. Zaya, Phyllis B. Malpas & Charles W. Locuson. (2008) In Vitro Drug-Drug Interaction Screens for Canine Veterinary Medicines: Evaluation of Cytochrome P450 Reversible Inhibition. Drug Metabolism and Disposition 36:8, pages 1512-1518.
Crossref
Butch KuKanich & Stacy L. Borum. (2008) Effects of ketoconazole on the pharmacokinetics and pharmacodynamics of morphine in healthy Greyhounds. American Journal of Veterinary Research 69:5, pages 664-669.
Crossref
Butch KuKanich & Stacy L Borum. (2008) The disposition and behavioral effects of methadone in Greyhounds. Veterinary Anaesthesia and Analgesia 35:3, pages 242-248.
Crossref
Steven Fleischer, Michele Sharkey, Katrina Mealey, Elaine A. Ostrander & Marilyn Martinez. (2008) Pharmacogenetic and Metabolic Differences Between Dog Breeds: Their Impact on Canine Medicine and the Use of the Dog as a Preclinical Animal Model. The AAPS Journal 10:1, pages 110-119.
Crossref
B. KUKANICH, J. F. COETZEE, R. GEHRING & M. HUBIN. (2007) Comparative disposition of pharmacologic markers for cytochrome P‐450 mediated metabolism, glomerular filtration rate, and extracellular and total body fluid volume of Greyhound and Beagle dogs. Journal of Veterinary Pharmacology and Therapeutics 30:4, pages 314-319.
Crossref
Katrina L. Mealey. (2006) Pharmacogenetics. Veterinary Clinics of North America: Small Animal Practice 36:5, pages 961-973.
Crossref
Lauren A. Trepanier. (2006) Cytochrome P450 and Its Role in Veterinary Drug Interactions. Veterinary Clinics of North America: Small Animal Practice 36:5, pages 975-985.
Crossref
Pierre J Ferré, Kirby Pasloske, Ted Whittem, Millagahamanda G Ranasinghe, Qiang Li & Hervé P Lefebvre. (2006) Plasma pharmacokinetics of alfaxalone in dogs after an intravenous bolus of Alfaxan-CD RTU. Veterinary Anaesthesia and Analgesia 33:4, pages 229-236.
Crossref
Peter J Pascoe, Janet E Ilkiw & Karen J Frischmeyer. (2006) The effect of the duration of propofol administration on recovery from anesthesia in cats. Veterinary Anaesthesia and Analgesia 33:1, pages 2-7.
Crossref
Robert P Hunter, MaryAnn Radlinsky, David E Koch, Matthew Corse, Marie A. Pellerin & Jennifer Halstead. (2005) Plasma pharmacokinetics and synovial fluid concentrations after oral administration of single and multiple doses of celecoxib in Greyhounds. American Journal of Veterinary Research 66:8, pages 1441-1445.
Crossref
Yunfei Wang, Margaret R. Spitz, Matthew B. Schabath, Francis Ali-Osman, Hilario Mata & Xifeng Wu. (2003) Association between glutathione S-transferase p1 polymorphisms and lung cancer risk in Caucasians: a case-control study. Lung Cancer 40:1, pages 25-32.
Crossref
J. Sallovitz, A. Lifschitz, F. Imperiale, A. Pis, G. Virkel & C. Lanusse. (2002) Breed Differences on the Plasma Availability of Moxidectin Administered Pour-on to Calves. The Veterinary Journal 164:1, pages 47-53.
Crossref
Yutaka Oda, Naoya Hamaoka, Toyoko Hiroi, Susumu Imaoka, Ichiro Hase, Kazuo Tanaka, Yoshihiko Funae, Takashi Ishizaki & Akira Asada. (2008) Involvement of human liver cytochrome P4502B6in the metabolism of propofol. British Journal of Clinical Pharmacology 51:3, pages 281-285.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.