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Xenobiotica
the fate of foreign compounds in biological systems
Volume 30, 2000 - Issue 6
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Research Article

Pharmacokinetics and metabolism of a sulphamide NK2 antagonist in rat, dog and human

K. Beaumont Department of Drug Metabolism, Pfizer Central Research, Sandwich CT13 9NJ, UK
,
A. Harper Early Clinical Research Group, Pfizer Central Research, Sandwich CT13 9NJ, UK
,
D. A. Smith Department of Drug Metabolism, Pfizer Central Research, Sandwich CT13 9NJ, UK
&
S. Abel Early Clinical Research Group, Pfizer Central Research, Sandwich CT13 9NJ, UK
Pages 627-642 | Published online: 22 Sep 2008

Citations (14)

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Read on this site (1)

R. Webster, S. Cole, J. Gedge, S. Roffey, D. Walker & W. Wild. (2003) Pharmacokinetics and disposition of a novel NMDA glycine site antagonist (UK-240,455) in rats, dogs and man. Xenobiotica 33:5, pages 541-560.
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Articles from other publishers (13)

Dennis A. SmithKevin Beaumont, Tristan S. Maurer & Li Di. (2018) Clearance in Drug Design. Journal of Medicinal Chemistry 62:5, pages 2245-2255.
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Dennis A. Smith, Kevin Beaumont, Tristan S. Maurer & Li Di. (2017) Relevance of Half-Life in Drug Design. Journal of Medicinal Chemistry 61:10, pages 4273-4282.
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Qiming Cao, Jimmy Yu & Des Connell. (2014) New Allometric Scaling Relationships and Applications for Dose and Toxicity Extrapolation. International Journal of Toxicology 33:6, pages 482-489.
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Alexander V. LyubimovKevin Beaumont. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 26 .
Stuart W. Paine, Karelle Ménochet, Rebecca Denton, Dermot F. McGinnity & Robert J. Riley. (2011) Prediction of Human Renal Clearance from Preclinical Species for a Diverse Set of Drugs That Exhibit Both Active Secretion and Net Reabsorption. Drug Metabolism and Disposition 39:6, pages 1008-1013.
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Toshihiro Wajima, Kazuya Fukumura, Yoshitaka Yano & Takayoshi Oguma. (2003) Prediction of human pharmacokinetics from animal data and molecular structural parameters using multivariate regression analysis: volume of distribution at steady state. Journal of Pharmacy and Pharmacology 55:7, pages 939-949.
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Donald S. Middleton, A. Roderick MacKenzie, Sandra D. Newman, Martin Corless, Andrew Warren, Allan P. Marchington & Barry Jones. (2005) Structure–activity relationships of 1-alkyl-5-(3,4-dichlorophenyl)-5-{2-[3-(substituted)-1-azetidinyl]-ethyl}-2-piperidones. Part 2: Improving oral absorption. Bioorganic & Medicinal Chemistry Letters 15:17, pages 3957-3961.
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Anthony Harrison, Alison Betts, Katherine Fenner, Kevin Beaumont, Alan Edgington, Sarah Roffey, John Davis, Pierre Comby & Paul Morgan. (2004) NONLINEAR ORAL PHARMACOKINETICS OF THE α-ANTAGONIST 4-AMINO-5-(4-FLUOROPHENYL)-6,7-DIMETHOXY-2-[4-(MORPHOLINOCARBONYL)-PERHYDRO-1,4-DIAZEPIN-1-YL]QUINOLINE IN HUMANS: USE OF PRECLINICAL DATA TO RATIONALIZE CLINICAL OBSERVATIONS. Drug Metabolism and Disposition 32:2, pages 197-204.
Crossref
X. Emonds-Alt. 2004. Tachykinins. Tachykinins 219 244 .
Toshihiro Wajima, Kazuya Fukumura, Yoshitaka Yano & Takayoshi Oguma. (2003) Prediction of Human Pharmacokinetics from Animal Data and Molecular Structural Parameters using Multivariate Regression Analysis: Oral Clearance. Journal of Pharmaceutical Sciences 92:12, pages 2427-2440.
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A. Roderick MacKenzieAllan P. MarchingtonDonald S. MiddletonSandra D. NewmanBarry C. Jones. (2002) Structure−Activity Relationships of 1-Alkyl-5-(3,4-dichlorophenyl)- 5-{2-[(3-substituted)-1-azetidinyl]ethyl}-2-piperidones. 1. Selective Antagonists of the Neurokinin-2 Receptor. Journal of Medicinal Chemistry 45:24, pages 5365-5377.
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Han van de WaterbeemdDennis A. SmithKevin BeaumontDon K. Walker. (2001) Property-Based Design:  Optimization of Drug Absorption and Pharmacokinetics. Journal of Medicinal Chemistry 44:9, pages 1313-1333.
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Kevin Beaumont, Alison Harper, Dennis A Smith & Joanne Bennett. (2000) The role of P-glycoprotein in determining the oral absorption and clearance of the NK2 antagonist, UK-224,671. European Journal of Pharmaceutical Sciences 12:1, pages 41-50.
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