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Xenobiotica
the fate of foreign compounds in biological systems
Volume 30, 2000 - Issue 9
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Research Article

High conservation of both phase I and II drug-metabolizing activities in cryopreserved rat liver slices

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Pages 891-903 | Published online: 22 Sep 2008

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H Xie, P Afsharian, Y Terelius, R. A Mirghani, Ü Yasar, A-L Hagbjörk, S Lundgren, Y Hu, A Rane & M Hassan. (2005) Cyclophosphamide induces mRNA, protein and enzyme activity of cytochrome P450 in rat. Xenobiotica 35:3, pages 239-251.
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Rolf Gebhardt, Jan G. Hengstler, Dieter Müller, Reinhild Glöckner, Peter Buenning, Britta Laube, Eva Schmelzer, Martina Ullrich, Dietmar Utesch, Nicola Hewitt, Michael Ringel, Beate Reder Hilz, Augustinus Bader, Angelika Langsch, Thomas Koose, Hans-Jörg Burger, Jochen Maas & Franz Oesch. (2003) New Hepatocyte In Vitro Systems for Drug Metabolism: Metabolic Capacity and Recommendations for Application in Basic Research and Drug Development, Standard Operation Procedures. Drug Metabolism Reviews 35:2-3, pages 145-213.
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Articles from other publishers (12)

Mostafa Kabiri. 2013. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays 1329 1351 .
Alexander V. LyubimovCostas Ioannides & Brian G. Lake. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 26 .
Inge A.M. de Graaf, Annelies L. Draaisma, Olaf Schoeman, Gregory M. Fahy, Geny M.M. Groothuis & Henk J. Koster. (2007) Cryopreservation of rat precision-cut liver and kidney slices by rapid freezing and vitrification. Cryobiology 54:1, pages 1-12.
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Miroslav Rypka, Kateřina Červenková, Lenka Uherková, Hana Poczatková, Anthony V. Florschutz & Jaroslav Veselý. (2006) A novel simplified ultra-rapid freezing technique for cryopreservation of tissue slices. Cryobiology 52:2, pages 193-199.
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Valérie P. Vanhulle, Audrey M. Neyrinck, Jean-Marie Pycke, Yves Horsmans & Nathalie M. Delzenne. (2006) Role of apoptotic signaling pathway in metabolic disturbances occurring in liver tissue after cryopreservation: Study on rat precision-cut liver slices. Life Sciences 78:14, pages 1570-1577.
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Marcella Martignoni, Mario Monshouwer, Ruben de Kanter, Daniele Pezzetta, Anna Moscone & Pietro Grossi. (2004) Phase I and phase II metabolic activities are retained in liver slices from mouse, rat, dog, monkey and human after cryopreservation. Toxicology in Vitro 18:1, pages 121-128.
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H. Axelsson, C. Granhall, E. Floby, Y. Jaksch, M. Svedling & A.-K. Sohlenius-Sternbeck. (2003) Rates of metabolism of chlorzoxazone, dextromethorphan, 7-ethoxycoumarin, imipramine, quinidine, testosterone and verapamil by fresh and cryopreserved rat liver slices, and some comparisons with microsomes. Toxicology in Vitro 17:4, pages 481-488.
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H Martin, B Bournique, B Blanchi & C Lerche-Langrand. (2003) High-throughput optimization by statistical designs: example with rat liver slices cryopreservation. Analytical Biochemistry 319:1, pages 56-64.
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I.A.M de Graaf & H.J Koster. (2003) Cryopreservation of precision-cut tissue slices for application in drug metabolism research. Toxicology in Vitro 17:1, pages 1-17.
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Collen M Masimirembwa, Ulf Bredberg & Tommy B Andersson. (2003) Metabolic Stability for Drug Discovery and Development. Clinical Pharmacokinetics 42:6, pages 515-528.
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A Lupp, R Glöckner, M Danz & D Müller. (2002) Cryopreserved precision-cut rat liver slices: morphology and cytochrome P450 isoforms expression after prolonged incubation. Toxicology in Vitro 16:6, pages 749-758.
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I.A.M. de Graaf & H.J. Koster. (2001) Water Crystallization within Rat Precision-Cut Liver Slices in Relation to Their Viability. Cryobiology 43:3, pages 224-237.
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