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Xenobiotica
the fate of foreign compounds in biological systems
Volume 30, 2000 - Issue 9
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Research Article

Identification of cytochrome P4503A as the major subfamily responsible for the metabolism of roquinimex in man

H. Tuvesson Pharmacokinetics and Metabolism, Active Biotech Research AB, PO Box 724, Lund, Sweden
,
L. C. Wienkers Drug Metabolism Research, Pharmacia & Upjohn, Kalamazoo, MI, USA
,
P. O. Gunnarsson Department of Cell and Molecular Biology, Lund University, Solvegatan 21, SE-223 62 Lund, Sweden
,
J. Seidegård Pharmacokinetics and Metabolism, Active Biotech Research AB, PO Box 724, Lund, Sweden
&
R. Persson Drug Metabolism Research, Pharmacia & Upjohn, Kalamazoo, MI, USA
Pages 905-914 | Published online: 22 Sep 2008

Citations (8)

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Read on this site (3)

John T Isaacs. (2010) The long and winding road for the development of tasquinimod as an oral second-generation quinoline-3-carboxamide antiangiogenic drug for the treatment of prostate cancer. Expert Opinion on Investigational Drugs 19:10, pages 1235-1243.
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H Tuvesson, I Hallin, M Ellman, B Sparre, P. O Gunnarsson & J Seidegård. (2005) In vitro metabolism and in vivo pharmacokinetics of quinoline 3-carboxamide derivatives in various species. Xenobiotica 35:3, pages 293-304.
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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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Articles from other publishers (5)

Larry C. Wienkers & Brooke M. Rock. 2021. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism 89 112 .
Yasushi Yamazoe & Kouichi Yoshinari. (2020) Prediction of regioselectivity and preferred order of CYP1A1-mediated metabolism: Solving the interaction of human and rat CYP1A1 forms with ligands on the template system. Drug Metabolism and Pharmacokinetics 35:1, pages 165-185.
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Larry C. Wienkers & Brooke Rock. 2014. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism 93 118 .
Helén Tuvesson, Ingrid Hallin, Robert Persson, Birgitta Sparre, Per Olov Gunnarsson & Janeric Seidegård. (2005) CYTOCHROME P450 3A4 IS THE MAJOR ENZYME RESPONSIBLE FOR THE METABOLISM OF LAQUINIMOD, A NOVEL IMMUNOMODULATOR. Drug Metabolism and Disposition 33:6, pages 866-872.
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Alexander Imhof & Roland Walter. 2002. 287 330 .

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