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Xenobiotica
the fate of foreign compounds in biological systems
Volume 30, 2000 - Issue 7
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Research Article

Comparison of celecoxib metabolism and excretion in mouse, rabbit, dog, cynomolgus monkey and rhesus monkey

S. K. Paulson Pharmacokinetics, Bioanalytical & Radiochemistry
,
J. Y. Zhang Regulatory Affairs
,
S. M. Jessen Physical Methodology, G. D. Searle & Co., 4901 Searle Parkway, Skokie, IL, USA
,
Y. Lawal Metabolic Chemistry, Covance Laboratories, Inc., Madison, WI, USA
,
N. W. K. Liu Pharmacokinetics, Bioanalytical & Radiochemistry
,
C. M. Dudkowski Regulatory Affairs
,
Y.-F. Wang Physical Methodology, G. D. Searle & Co., 4901 Searle Parkway, Skokie, IL, USA
,
M. Chang Metabolic Chemistry, Covance Laboratories, Inc., Madison, WI, USA
,
D. Yang Pharmacokinetics, Bioanalytical & Radiochemistry
,
J. W. A. Findlay Regulatory Affairs
,
M. A. Berge Physical Methodology, G. D. Searle & Co., 4901 Searle Parkway, Skokie, IL, USA
,
C. S. Markos Metabolic Chemistry, Covance Laboratories, Inc., Madison, WI, USA
,
A. P. Breau Pharmacokinetics, Bioanalytical & Radiochemistry
,
J. D. Hribar Regulatory Affairs
&
J. Yuan Physical Methodology, G. D. Searle & Co., 4901 Searle Parkway, Skokie, IL, USA
 show all
Pages 731-744 | Published online: 22 Sep 2008

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You Shang, Jiadi Du & Hong Cui. (2014) Synthesis of Celecoxib, its Pro-drugs and Radiolabeled Derivatives. A Brief Review. Organic Preparations and Procedures International 46:2, pages 132-151.
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Miha Homar, Nathalie Ubrich, Fatima El Ghazouani, Julijana Kristl, Janez Kerč & Philippe Maincent. (2007) Influence of polymers on the bioavailability of microencapsulated celecoxib. Journal of Microencapsulation 24:7, pages 621-633.
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Kathleen M Knights, Paraskevi Tsoutsikos & John O Miners. (2005) Novel mechanisms of nonsteroidal anti-inflammatory drug-induced renal toxicity. Expert Opinion on Drug Metabolism & Toxicology 1:3, pages 399-408.
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J. Y. Zhang, Y. F. Wang, M. N. Milton, M. Beconi, M. Chang, D. Yin, A. P. Breau & S. K. Paulson. (2003) Pharmacokinetics, metabolism and excretion of an inhibitor of inducible nitric oxide synthase, L-NIL-TA, in dog. Xenobiotica 33:11, pages 1159-1171.
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Articles from other publishers (15)

Chantal L. Rytz, Sandra M. Dumanski, Darlene Y. Sola & Sofia B. Ahmed. (2023) The Effect of Biological Sex on Arterial Stiffness and Renin-Angiotensin-Aldosterone System Activity in Response to Cyclooxygenase-2 (COX-2) Inhibition. CJC Open 5:2, pages 112-119.
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Michael Benedict Subhahar, Jaipaul Singh, Peter Henry Albert & Ahmed Mahmoud Kadry. (2019) Pharmacokinetics, metabolism and excretion of celecoxib, a selective cyclooxygenase‐2 inhibitor, in horses. Journal of Veterinary Pharmacology and Therapeutics 42:5, pages 518-524.
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Christine Péladeau, Nadine J. Adam & Bernard J. Jasmin. (2018) Celecoxib treatment improves muscle function in mdx mice and increases utrophin A expression. The FASEB Journal 32:9, pages 5090-5103.
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Beatriz de Rienzo-Madero, Ulises Coffeen, Karina Simón-Arceo, Francisco Mercado, Orlando Jaimes, Lucía Magis-Weinberg, Bernardo Contreras & Francisco Pellicer. (2013) Taurine Enhances Antinociception Produced by a COX-2 Inhibitor in an Inflammatory Pain Model. Inflammation 36:3, pages 658-664.
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Misato Takashima-Hirano, Tadayuki Takashima, Yumiko Katayama, Yasuhiro Wada, Yuichi Sugiyama, Yasuyoshi Watanabe, Hisashi Doi & Masaaki Suzuki. (2011) Efficient sequential synthesis of PET Probes of the COX-2 inhibitor [11C]celecoxib and its major metabolite [11C]SC-62807 and in vivo PET evaluation. Bioorganic & Medicinal Chemistry 19:9, pages 2997-3004.
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S. R. COX, S. P. LESMAN, J. F. BOUCHER, M. J. KRAUTMANN, B. D. HUMMEL, M. SAVIDES, S. MARSH, A. FIELDER & M. R. STEGEMANN. (2010) The pharmacokinetics of mavacoxib, a long-acting COX-2 inhibitor, in young adult laboratory dogs. Journal of Veterinary Pharmacology and Therapeutics 33:5, pages 461-470.
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Shayne Cox GadMary Jane Cunningham & Mrinal Shah. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
Kara R. Schmelzer, Bora Inceoglu, Lukas KubalaIn-Hae Kim, Steven L. Jinks, Jason P. Eiserich & Bruce D. Hammock. (2006) Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors. Proceedings of the National Academy of Sciences 103:37, pages 13646-13651.
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Robert P Hunter, MaryAnn Radlinsky, David E Koch, Matthew Corse, Marie A. Pellerin & Jennifer Halstead. (2005) Plasma pharmacokinetics and synovial fluid concentrations after oral administration of single and multiple doses of celecoxib in Greyhounds. American Journal of Veterinary Research 66:8, pages 1441-1445.
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Kai Wang, Khaldoun Tarakji, Zhongmin Zhou, Ming Zhang, Farhad Forudi, Xiaorong Zhou, Alane T. Koki, Mark E. Smith, Bradley T. Keller, Eric J. Topol, A. Michael Lincoff & Marc S. Penn. (2005) Celecoxib, a Selective Cyclooxygenase-2 Inhibitor, Decreases Monocyte Chemoattractant Protein-1 Expression and Neointimal Hyperplasia in the Rabbit Atherosclerotic Balloon Injury Model. Journal of Cardiovascular Pharmacology 45:1, pages 61-67.
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Ji Y. Zhang, Yuefen Wang, Mark N. Milton, Lori Kraus, Alan P. Breau & Susan K. Paulson. (2004) Disposition and Pharmacokinetics of L-N6-(1-Iminoethyl)Lysine-5-Tetrazole-Amide, a Selective iNOS Inhibitor, in Rats. Journal of Pharmaceutical Sciences 93:5, pages 1229-1240.
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Ji Y. Zhang, Fran Xu & Alan P. Breau. (2004) Collision‐induced dissociation of valdecoxib metabolites: a novel rearrangement involving an isoxazole ring. Journal of Mass Spectrometry 39:3, pages 295-302.
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K. D. Rainsford. 2004. COX-2 Inhibitors. COX-2 Inhibitors 67 131 .
Susan K. Paulson & Timothy J. Maziasz. 2004. Applications of Pharmacokinetic Principles in Drug Development. Applications of Pharmacokinetic Principles in Drug Development 405 425 .
Ji Y. Zhang, Josh J. Yuan, Yue-Fen Wang, Roy H. BibleJr.Jr. & Alan P. Breau. (2003) Pharmacokinetics and Metabolism of a COX-2 Inhibitor, Valdecoxib, in Mice. Drug Metabolism and Disposition 31:4, pages 491-501.
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