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Xenobiotica
the fate of foreign compounds in biological systems
Volume 30, 2000 - Issue 8
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Research Article

Characterization of transgenic mouse strains using six human hepatic cytochrome P450 probe substrates

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Pages 745-754 | Published online: 22 Sep 2008

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M. R. Shiran, N. J. Proctor, E. M. Howgate, K. Rowland-Yeo, G. T. Tucker & A. Rostami-Hodjegan. (2006) Prediction of metabolic drug clearance in humans: extrapolation allometric scaling. Xenobiotica 36:7, pages 567-580.
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E. M. Howgate, K. Rowland Yeo, N. J. Proctor, G. T. Tucker & A. Rostami-Hodjegan. (2006) Prediction of in vivo drug clearance from in vitro data. I: Impact of inter-individual variability. Xenobiotica 36:6, pages 473-497.
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S. Löfgren, A.-L. Hagbjörk, S. Ekman, R. Fransson-Steen & Y. Terelius. (2004) Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison. Xenobiotica 34:9, pages 811-834.
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N. J. Proctor, G. T. Tucker & A. Rostami-Hodjegan. (2004) Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors. Xenobiotica 34:2, pages 151-178.
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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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Articles from other publishers (7)

Juliane Rudeck, Bettina Bert, Philip Marx-Stoelting, Gilbert Schönfelder & Silvia Vogl. (2018) Liver lobe and strain differences in the activity of murine cytochrome P450 enzymes. Toxicology 404-405, pages 76-85.
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Yi Zhu & Qing-Yu Zhang. (2012) Role of Intestinal Cytochrome P450 Enzymes in Diclofenac-Induced Toxicity in the Small Intestine. Journal of Pharmacology and Experimental Therapeutics 343:2, pages 362-370.
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Bartłomiej Milanowski, Janina Lulek, Hans-Joachim Lehmler & Izabela Kania-Korwel. (2010) Assessment of the disposition of chiral polychlorinated biphenyls in female mdr 1a/b knockout versus wild-type mice using multivariate analyses. Environment International 36:8, pages 884-892.
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Gemma L. Dickinson, Saeed Rezaee, Nicholas J. Proctor, Martin S. Lennard, Geoffrey T. Tucker & Amin Rostami-Hodjegan. (2007) Incorporating In Vitro Information on Drug Metabolism Into Clinical Trial Simulations to Assess the Effect of CYP2D6 Polymorphism on Pharmacokinetics and Pharmacodynamics: Dextromethorphan as a Model Application. The Journal of Clinical Pharmacology 47:2, pages 175-186.
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Anita A. Mathias, Lillian Maggio-Price, Yurong Lai, Anshul Gupta & Jashvant D. Unadkat. (2006) Changes in Pharmacokinetics of Anti-HIV Protease Inhibitors during Pregnancy: The Role of CYP3A and P-glycoprotein. Journal of Pharmacology and Experimental Therapeutics 316:3, pages 1202-1209.
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Miki Katoh, Tomohito Matsui, Miki Nakajima, Chise Tateno, Miho Kataoka, Yoshinori Soeno, Toru Horie, Kazuhide Iwasaki, Katsutoshi Yoshizato & Tsuyoshi Yokoi. (2004) EXPRESSION OF HUMAN CYTOCHROMES P450 IN CHIMERIC MICE WITH HUMANIZED LIVER. Drug Metabolism and Disposition 32:12, pages 1402-1410.
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Sean Ekins, Barbara J. Ring, James Grace, Donna J. McRobie-Belle & Steven A. Wrighton. (2000) Present and future in vitro approaches for drug metabolism. Journal of Pharmacological and Toxicological Methods 44:1, pages 313-324.
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