Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 30, 2000 - Issue 8
65
Views
20
CrossRef citations to date
0
Altmetric
Research Article

Pharmacokinetics of the M1-agonist talsaclidine in mouse, rat, rabbit and monkey, and extrapolation to man

, , &
Pages 797-814 | Published online: 22 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Zhenhua Jia, Hong Ma, Yali Huang, Yuanyuan Huang, Pengju Ren, Shuishan Song, Meirong Hu & Yong Tao. (2018) Production of (R)-3-quinuclidinol by a whole-cell biocatalyst with high efficiency. Biocatalysis and Biotransformation 36:4, pages 316-323.
Read now
Masaru Tanokura, Takuya Miyakawa, Lijun Guan & Feng Hou. (2015) Structural analysis of enzymes used for bioindustry and bioremediation. Bioscience, Biotechnology, and Biochemistry 79:9, pages 1391-1401.
Read now
Pascal Espié, Dominique Tytgat, Maria-Laura Sargentini-Maier, Italo Poggesi & Jean-Baptiste Watelet. (2009) Physiologically based pharmacokinetics (PBPK). Drug Metabolism Reviews 41:3, pages 391-407.
Read now

Articles from other publishers (17)

Satoru Watanabe, Masahiro Ito & Takanori Kigawa. (2021) DiRect: Site-directed mutagenesis method for protein engineering by rational design. Biochemical and Biophysical Research Communications 551, pages 107-113.
Crossref
Daijiro Takeshita, Michihiko Kataoka, Takuya Miyakawa, Ken-ichi Miyazono, Shoko Kumashiro, Takahiro Nagai, Nobuyuki Urano, Atsuko Uzura, Koji Nagata, Sakayu Shimizu & Masaru Tanokura. (2014) Structural basis of stereospecific reduction by quinuclidinone reductase. AMB Express 4:1.
Crossref
Feng Hou, Takuya Miyakawa, Michihiko Kataoka, Daijiro Takeshita, Shoko Kumashiro, Atsuko Uzura, Nobuyuki Urano, Koji Nagata, Sakayu Shimizu & Masaru Tanokura. (2014) Structural basis for high substrate-binding affinity and enantioselectivity of 3-quinuclidinone reductase AtQR. Biochemical and Biophysical Research Communications 446:4, pages 911-915.
Crossref
Wen-Xia Zhang, Guo-Chao Xu, Lei Huang, Jiang Pan, Hui-Lei Yu & Jian-He Xu. (2013) Highly Efficient Synthesis of ( R )-3-Quinuclidinol in a Space–Time Yield of 916 g L –1 d –1 Using a New Bacterial Reductase Ar QR . Organic Letters 15:19, pages 4917-4919.
Crossref
Yu Wang, Jianjiong Li, Qiaqing Wu & Dunming Zhu. (2013) Microbial stereospecific reduction of 3-quinuclidinone with newly isolated Nocardia sp. and Rhodococcus erythropolis. Journal of Molecular Catalysis B: Enzymatic 88, pages 14-19.
Crossref
Feng Hou, Takuya Miyakawa, Daijiro Takeshita, Michihiko Kataoka, Atsuko Uzura, Koji Nagata, Sakayu Shimizu & Masaru Tanokura. (2012) Expression, purification, crystallization and X-ray analysis of 3-quinuclidinone reductase from Agrobacterium tumefaciens . Acta Crystallographica Section F Structural Biology and Crystallization Communications 68:10, pages 1237-1239.
Crossref
Urban Fagerholm. (2007) Prediction of human pharmacokinetics — renal metabolic and excretion clearance. Journal of Pharmacy and Pharmacology 59:11, pages 1463-1471.
Crossref
Atsuko Uzura, Fumiki Nomoto, Akiko Sakoda, Yukifumi Nishimoto, Michihiko Kataoka & Sakayu Shimizu. (2009) Stereoselective synthesis of (R)-3-quinuclidinol through asymmetric reduction of 3-quinuclidinone with 3-quinuclidinone reductase of Rhodotorula rubra. Applied Microbiology and Biotechnology 83:4, pages 617-626.
Crossref
Kunihiko Tsutsumi, Takeaki Katayama, Noriyuki Utsumi, Kunihiko Murata, Noriyoshi Arai, Nobuhito Kurono & Takeshi Ohkuma. (2009) Practical Asymmetric Hydrogenation of 3-Quinuclidinone Catalyzed by the XylSkewphos/PICA−Ruthenium(II) Complex. Organic Process Research & Development 13:3, pages 625-628.
Crossref
Huadong Tang & Michael Mayersohn. (2006) A global examination of allometric scaling for predicting human drug clearance and the prediction of large vertical allometry**This work was presented at the American Association of Pharmaceutical Scientists Annual meeting, Salt Lake City, USA, Oct. 26, 2003.. Journal of Pharmaceutical Sciences 95:8, pages 1783-1799.
Crossref
Huadong Tang & Michael Mayersohn. (2005) A NOVEL MODEL FOR PREDICTION OF HUMAN DRUG CLEARANCE BY ALLOMETRIC SCALING. Drug Metabolism and Disposition 33:9, pages 1297-1303.
Crossref
Masaya Ikunaka. (2004) Biocatalysis from the perspective of an industrial practitioner: let a biocatalyst do a job that no chemocatalyst can. Catalysis Today 96:3, pages 93-102.
Crossref
Olivier Luttringer, Frank‐Peter Theil, Patrick Poulin, Anne H. Schmitt‐Hoffmann, Theodor Walter Guentert & Thierry Lavé. (2003) Physiologically Based Pharmacokinetic (PBPK) Modeling of Disposition of Epiroprim in Humans. Journal of Pharmaceutical Sciences 92:10, pages 1990-2007.
Crossref
Fumiki Nomoto, Yoshihiko Hirayama, Masaya Ikunaka, Toru Inoue & Koutaro Otsuka. (2003) A practical chemoenzymatic process to access (R)-quinuclidin-3-ol on scale. Tetrahedron: Asymmetry 14:13, pages 1871-1877.
Crossref
Yasuo Chikusa, Yoshihiro Hirayama, Masaya Ikunaka, Toru Inoue, Shunji Kamiyama, Masafumi Moriwaki, Yukifumi Nishimoto, Fumiki Nomoto, Kazuo Ogawa, Tomoyasu Ohno, Koutaro Otsuka, Akiko K. Sakota, Naoki Shirasaka, Atsuko Uzura & Kensaku Uzura. (2003) There's No Industrial Biocatalyst Like Hydrolase:  Development of Scalable Enantioselective Processes Using Hydrolytic Enzymes 1 . Organic Process Research & Development 7:3, pages 289-296.
Crossref
Marion Wienrich, Angelo Ceci, Helmut A. Ensinger, Wolfram Gaida, Klaus D. Mendla, Takeshi Osugi, Andreas Raschig & Thomas Weiser. (2002) Talsaclidine (WAL 2014 FU), a muscarinic M1 receptor agonist for the treatment of Alzheimer's disease. Drug Development Research 56:3, pages 321-334.
Crossref
Teh-Min Hu & William L. Hayton. (2015) Allometric scaling of xenobiotic clearance: Uncertainty versus universality. AAPS PharmSci 3:4, pages 30-43.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.