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Xenobiotica
the fate of foreign compounds in biological systems
Volume 30, 2000 - Issue 10
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Research Article

Use of everted sacs of mouse small intestine as enzyme sources for the study of drug oxidation activities in vitro

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Pages 971-982 | Published online: 22 Sep 2008

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C. Emoto, H. Yamazaki, H. Iketaki, S. Yamasaki, T. Satoh, R. Shimizu, S. Suzuki, N. Shimada, M. Nakajima & T. Yokoi. (2001) Cooperativity of α-naphthoflavone in cytochrome P450 3A-dependent drug oxidation activities in hepatic and intestinal microsomes from mouse and human. Xenobiotica 31:5, pages 265-275.
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Oliver J.D. Hatley, Christopher R. Jones, Aleksandra Galetin & Amin Rostami‐Hodjegan. (2017) Optimization of intestinal microsomal preparation in the rat: A systematic approach to assess the influence of various methodologies on metabolic activity and scaling factors. Biopharmaceutics & Drug Disposition 38:3, pages 187-208.
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Sheila Annie Peters, Christopher R. Jones, Anna-Lena Ungell & Oliver J. D. Hatley. (2016) Predicting Drug Extraction in the Human Gut Wall: Assessing Contributions from Drug Metabolizing Enzymes and Transporter Proteins using Preclinical Models. Clinical Pharmacokinetics 55:6, pages 673-696.
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Yanan Sun, Mengshu WangBingxue Sun, Feng Li, Shubo Liu, Yong Zhang, Yan Zhou, Yan Chen & Wei Kong. (2016) An Investigation into the Gastrointestinal Stability of Exenatide in the Presence of Pure Enzymes, Everted Intestinal Rings and Intestinal Homogenates. Biological & Pharmaceutical Bulletin Biological and Pharmaceutical Bulletin 39:1, pages 42-48.
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Mohd Aftab Alam, Fahad Ibrahim Al-Jenoobi & Abdullah M Al-mohizea. (2012) Everted gut sac model as a tool in pharmaceutical research: limitations and applications. Journal of Pharmacy and Pharmacology 64:3, pages 326-336.
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Kevin J. Randall, John Turton & John R. Foster. (2011) Explant culture of gastrointestinal tissue: a review of methods and applications. Cell Biology and Toxicology 27:4, pages 267-284.
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X W Teng, D J Cutler & N M Davies. (2003) Kinetics of metabolism and degradation of mometasone furoate in rat biological fluids and tissues. Journal of Pharmacy and Pharmacology 55:5, pages 617-630.
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P. Hodek, J. Křížková, K. Burdová, M. Šulc, R. Kizek, J. Hudeček & M. Stiborová. (2009) Chemopreventive compounds—View from the other side. Chemico-Biological Interactions 180:1, pages 1-9.
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Hiroshi Komura & Masahiro Iwaki. (2008) Species Differences in In Vitro and In Vivo Small Intestinal Metabolism of CYP3A Substrates. Journal of Pharmaceutical Sciences 97:5, pages 1775-1800.
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Marcella Martignoni, Geny Groothuis & Ruben de Kanter. (2006) COMPARISON OF MOUSE AND RAT CYTOCHROME P450-MEDIATED METABOLISM IN LIVER AND INTESTINE. Drug Metabolism and Disposition 34:6, pages 1047-1054.
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Anita A. Mathias, Lillian Maggio-Price, Yurong Lai, Anshul Gupta & Jashvant D. Unadkat. (2006) Changes in Pharmacokinetics of Anti-HIV Protease Inhibitors during Pregnancy: The Role of CYP3A and P-glycoprotein. Journal of Pharmacology and Experimental Therapeutics 316:3, pages 1202-1209.
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Esther G. van de Kerkhof, Inge A. M. de Graaf, Marina H. de Jager, Dirk K. F. Meijer & Geny M. M. Groothuis. (2005) CHARACTERIZATION OF RAT SMALL INTESTINAL AND COLON PRECISION-CUT SLICES AS AN IN VITRO SYSTEM FOR DRUG METABOLISM AND INDUCTION STUDIES. Drug Metabolism and Disposition 33:11, pages 1613-1620.
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Laurence S. Kaminsky & Qing-Yu Zhang. (2003) THE SMALL INTESTINE AS A XENOBIOTIC-METABOLIZING ORGAN. Drug Metabolism and Disposition 31:12, pages 1520-1525.
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Qing-Yu Zhang, Debbie Dunbar & Laurence S. Kaminsky. (2003) CHARACTERIZATION OF MOUSE SMALL INTESTINAL CYTOCHROME P450 EXPRESSION. Drug Metabolism and Disposition 31:11, pages 1346-1351.
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Hiroshi Yamazaki, Hitomi Iketaki, Ayaka Shibata, Miki Nakajima & Tsuyoshi Yokoi. (2002) Activities of Cytochrome P450 Enzymes in Liver and Kidney Microsomes from Systemic Carnitine Deficiency Mice with a Gene Mutation of Carnitine/Organic Cation Transporter. Drug Metabolism and Pharmacokinetics 17:1, pages 47-53.
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