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Xenobiotica
the fate of foreign compounds in biological systems
Volume 30, 2000 - Issue 10
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Research Article

Determination, pharmacokinetics and protein binding of a novel tissue-type plasminogen activator, pamiteplase in human plasma

K. Oikawa Drug Metabolism Laboratories, Yamanouchi Pharmaceutical Co. Ltd, 1-8 Azusawa 1-chome Itabashi-ku, Tokyo 174-8511, Japan
,
T. Watanabe Clinical Development Department, Yamanouchi Pharmaceutical Co. Ltd, 1-8 Azusawa 1-chome Itabashi-ku, Tokyo 174-8511, Japan
,
I. Miyamoto Drug Metabolism Laboratories, Yamanouchi Pharmaceutical Co. Ltd, 1-8 Azusawa 1-chome Itabashi-ku, Tokyo 174-8511, Japan
&
S. Higuchi Clinical Development Department, Yamanouchi Pharmaceutical Co. Ltd, 1-8 Azusawa 1-chome Itabashi-ku, Tokyo 174-8511, Japan
Pages 993-1003 | Published online: 22 Sep 2008

Citations (6)

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Yeamin Huh, David E Smith & Meihau Rose Feng. (2011) Interspecies scaling and prediction of human clearance: comparison of small- and macro-molecule drugs. Xenobiotica 41:11, pages 972-987.
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Articles from other publishers (5)

Patrizia Cioni, Edi Gabellieri, Barbara Campanini, Stefano Bettati & Samanta Raboni. (2022) Use of Exogenous Enzymes in Human Therapy: Approved Drugs and Potential Applications. Current Medicinal Chemistry 29:3, pages 411-452.
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Patrick Poulin. (2011) A Single-Species Approach Considering Additional Physiological Information for Prediction of Hepatic Clearance of Glycoprotein Derivate Therapeutics. Clinical Pharmacokinetics 50:10, pages 665-674.
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Weirong Wang & Thomayant Prueksaritanont. (2010) Prediction of human clearance of therapeutic proteins: simple allometric scaling method revisited. Biopharmaceutics & Drug Disposition 31:4, pages 253-263.
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I. MAHMOOD. (2009) Pharmacokinetic allometric scaling of coagulation factors and tissue-type plasminogen activators. Haemophilia 15:5, pages 1109-1117.
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Iftekhar Mahmood. (2009) Role of Fixed Coefficients and Exponents in the Prediction of Human Drug Clearance: How Accurate are the Predictions from One or Two Species?. Journal of Pharmaceutical Sciences 98:7, pages 2472-2493.
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