Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 30, 2000 - Issue 10
Submit an article Journal homepage
68
Views
15
CrossRef citations to date
0
Altmetric
Research Article

Metabolic activation of o-phenylphenol to a major cytotoxic metabolite, phenylhydroquinone: role of human CYP1A2 and rat CYP2C11/CYP2E1

S. Ozawa Division of Pharmacology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
,
K. Ohta Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University, 3-3165 Higashitamagawagakuen, Machida, Tokyo 194-8543, Japan
,
A. Miyajima Division of Pharmacology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
,
H. Kurebayashi Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University, 3-3165 Higashitamagawagakuen, Machida, Tokyo 194-8543, Japan
,
M. Sunouchi Division of Pharmacology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
,
M. Shimizu Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University, 3-3165 Higashitamagawagakuen, Machida, Tokyo 194-8543, Japan
,
N. Murayama Division of Pharmacology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
,
Y. Matsumoto Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University, 3-3165 Higashitamagawagakuen, Machida, Tokyo 194-8543, Japan
,
M. Fukuoka Division of Pharmacology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
&
Y. Ohno Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University, 3-3165 Higashitamagawagakuen, Machida, Tokyo 194-8543, Japan
 show all
Pages 1005-1017 | Published online: 22 Sep 2008

Citations (15)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Kevin A. Ford, Gregory Ryslik, Jasleen Sodhi, Jason Halladay, Dolo Diaz, Donna Dambach & Melisa Masuda. (2015) Computational predictions of the site of metabolism of cytochrome P450 2D6 substrates: comparative analysis, molecular docking, bioactivation and toxicological implications. Drug Metabolism Reviews 47:3, pages 291-319.
Read now
Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
Read now

Articles from other publishers (13)

Blanche C Ip, Samantha J Madnick, Sophia Zheng, Tessa C A van Tongeren, Susan J Hall, Hui Li, Suzanne Martin, Sandrine Spriggs, Paul Carmichael, Wei Chen, David Ames, Lori A Breitweiser, Heather E Pence, Andrew J Bowling, Kamin J Johnson, Richard Cubberley, Jeffrey R Morgan & Kim Boekelheide. (2024) Development of a human liver microphysiological coculture system for higher throughput chemical safety assessment. Toxicological Sciences.
Crossref
Yasushi Yamazoe, Norie Murayama & Kouichi Yoshinari. (2021) Refined CYP2E1∗ Template∗∗ system to decipher the ligand-interactions. Drug Metabolism and Pharmacokinetics 41, pages 100413.
Crossref
Shogo Ozawa, Toshitaka Miura, Jun Terashima, Wataru Habano & Seiichi Ishida. (2021) Recent Progress in Prediction Systems for Drug-induced Liver Injury Using In vitro Cell Culture. Drug Metabolism Letters 14:1, pages 25-40.
Crossref
Chad Deisenroth, Danica E DeGroot, Todd Zurlinden, Andrew Eicher, James McCord, Mi-Young Lee, Paul Carmichael & Russell S Thomas. (2020) The Alginate Immobilization of Metabolic Enzymes Platform Retrofits an Estrogen Receptor Transactivation Assay With Metabolic Competence. Toxicological Sciences 178:2, pages 281-301.
Crossref
Cristina Travelli, Silvio Aprile, Daiana Mattoteia, Giorgia Colombo, Nausicaa Clemente, Eugenio Scanziani, Salvatore Terrazzino, Maria Alessandra Alisi, Lorenzo Polenzani, Giorgio Grosa, Armando A. Genazzani, Gian Cesare Tron & Ubaldina Galli. (2019) Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group. European Journal of Medicinal Chemistry 181, pages 111576.
Crossref
Ya-Wen Hsiao, Carl Petersson, Mats A. Svensson & Ulf Norinder. (2012) A Pragmatic Approach Using First-Principle Methods to Address Site of Metabolism with Implications for Reactive Metabolite Formation. Journal of Chemical Information and Modeling 52:3, pages 686-695.
Crossref
Ruri Kikura-Hanajiri, Maiko Kawamura, Atsuko Miyajima, Momoko Sunouchi & Yukihiro Goda. (2011) Chiral analyses of dextromethorphan/levomethorphan and their metabolites in rat and human samples using LC-MS/MS. Analytical and Bioanalytical Chemistry 400:1, pages 165-174.
Crossref
Katie Chan, Hans‐Joachim Lehmler, Milani Sivagnanam, Cynthia Yan Feng, Larry Robertson & Peter J. O'Brien. (2009) Cytotoxic effects of polychlorinated biphenyl hydroquinone metabolites in rat hepatocytes. Journal of Applied Toxicology 30:2, pages 163-171.
Crossref
Patrik Rydberg, Poongavanam Vasanthanathan, Chris Oostenbrink & Lars Olsen. (2009) Fast Prediction of Cytochrome P450 Mediated Drug Metabolism. ChemMedChem 4:12, pages 2070-2079.
Crossref
Tracey L.H. Jason, James Koropatnick & Randal W. Berg. (2004) Toxicology of antisense therapeutics. Toxicology and Applied Pharmacology 201:1, pages 66-83.
Crossref
Robert D. Combes. (2019) The Case for Taking Account of Metabolism when Testing for Potential Endocrine Disruptors In Vitro . Alternatives to Laboratory Animals 32:2, pages 121-135.
Crossref
Shigeyuki Kitamura, Seigo Sanoh, Ryuki Kohta, Tomoharu Suzuki, Kazumi Sugihara, Nariaki Fujimoto & Shigeru Ohta. (2003) Metabolic Activation of Proestrogenic Diphenyl and Related Compounds by Rat Liver Microsomes. Journal of Health Science 49:4, pages 298-310.
Crossref
. (2002) Chapter 7: Biokinetics. Alternatives to Laboratory Animals 30:1_suppl, pages 55-70.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.