Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 31, 2001 - Issue 5
Submit an article Journal homepage
67
Views
26
CrossRef citations to date
0
Altmetric
Research Article

Identification and reactivity of the major metabolite (ß-1-glucuronide) of the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in humans

S. F. Zhou Department of Pharmacology and Clinical Pharmacology, Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand
,
J. W. Paxton Department of Pharmacology and Clinical Pharmacology, Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand
,
M. D. Tingle Department of Pharmacology and Clinical Pharmacology, Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand
,
P. Kestell Department of Pharmacology and Clinical Pharmacology, Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand
,
M. B. Jameson Department of Pharmacology and Clinical Pharmacology, Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand
,
P. I. Thompson Department of Pharmacology and Clinical Pharmacology, Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand
&
B. C. Baguley Department of Pharmacology and Clinical Pharmacology, Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand
 show all
Pages 277-293 | Published online: 22 Sep 2008

Citations (26)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Shufeng Zhou, Eli Chan, Wei Duan, Min Huang & Yu-Zong Chen. (2005) Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance. Drug Metabolism Reviews 37:1, pages 41-213.
Read now
Shufeng Zhou, Philip Kestell & James W. Paxton. (2002) PREDICTING PHARMACOKINETICS AND DRUG INTERACTIONS IN PATIENTS FROM IN VITRO AND IN VIVO MODELS: THE EXPERIENCE WITH 5,6-DIMETHYLXANTHENONE-4-ACETIC ACID (DMXAA), AN ANTI-CANCER DRUG ELIMINATED MAINLY BY CONJUGATION. Drug Metabolism Reviews 34:4, pages 751-790.
Read now

Articles from other publishers (24)

Sandrina A. Heleno, Anabela Martins, Maria João R.P. Queiroz & Isabel C.F.R. Ferreira. (2015) Bioactivity of phenolic acids: Metabolites versus parent compounds: A review. Food Chemistry 173, pages 501-513.
Crossref
Bruce C Baguley & Mark J McKeage. (2014) Therapeutic targeting of tumor angiogenesis: how far have we come?. Clinical Investigation 4:12, pages 1113-1122.
Crossref
David Jamieson, Sally A. Coulthard & Alan V. Boddy. 2014. Handbook of Anticancer Pharmacokinetics and Pharmacodynamics. Handbook of Anticancer Pharmacokinetics and Pharmacodynamics 229 254 .
Jin Zhou, Feng Frank Li & Jeffrey X. Duggan. 2013. Handbook of LC-MS Bioanalysis. Handbook of LC-MS Bioanalysis 447 460 .
Duygu Yeniceli, Xiaolan Deng, Erwin Adams, Dilek Dogrukol‐Ak & Ann Van Schepdael. (2012) Development of a CD‐MEKC method for investigating the metabolism of tamoxifen by flavin‐containing monooxygenases and the inhibitory effects of methimazole, nicotine and DMXAA. ELECTROPHORESIS 34:3, pages 463-470.
Crossref
A. Piazzon, U. Vrhovsek, D. Masuero, F. Mattivi, F. Mandoj & M. Nardini. (2012) Antioxidant Activity of Phenolic Acids and Their Metabolites: Synthesis and Antioxidant Properties of the Sulfate Derivatives of Ferulic and Caffeic Acids and of the Acyl Glucuronide of Ferulic Acid. Journal of Agricultural and Food Chemistry 60:50, pages 12312-12323.
Crossref
M. J. McKeage, P. C. Fong, X. Hong, J. Flarakos, J. Mangold, Y. Du, C. Tanaka & H. Schran. (2012) Mass balance, excretion and metabolism of [14C] ASA404 in cancer patients in a phase I trial. Cancer Chemotherapy and Pharmacology 69:5, pages 1145-1154.
Crossref
Yongqian Zhang, Zhihui Xu & Yulin Deng. (2011) Characterization of flavone glycosides and aglycones in Cephalotaxus sinensis by HPLC-DAD-MS. Analytical Methods 3:6, pages 1386.
Crossref
Jacqueline RamírezMark J RatainFederico Innocenti. (2010) Uridine 5´-diphospho-glucuronosyltransferase genetic polymorphisms and response to cancer chemotherapy. Future Oncology 6:4, pages 563-585.
Crossref
Xiao-Xia Yang, Ze-Ping Hu, Sui Yung Chan & Shu-Feng Zhou. (2006) Monitoring drug–protein interaction. Clinica Chimica Acta 365:1-2, pages 9-29.
Crossref
Shufeng Zhou, Xia Feng, Philip Kestell, James W. Paxton, Bruce C. Baguley & Eli Chan. (2005) Transport of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid and its acyl glucuronide by human intestinal Caco-2 cells. European Journal of Pharmaceutical Sciences 24:5, pages 513-524.
Crossref
Shufeng Zhou, Xia Feng, Philip Kestell, Bruce C. Baguley & James W. Paxton. (2004) Determination of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid and its acyl glucuronide in Caco-2 monolayers by liquid chromatography with fluorescence detection: application to transport studies. Journal of Chromatography B 809:1, pages 87-97.
Crossref
Sally A. Coulthard & Alan V. Boddy. 2004. Handbook of Anticancer Pharmacokinetics and Pharmacodynamics. Handbook of Anticancer Pharmacokinetics and Pharmacodynamics 189 213 .
Shufeng Zhou. (2003) Separation and detection methods for covalent drug–protein adducts. Journal of Chromatography B 797:1-2, pages 63-90.
Crossref
Apurva A Desai, Federico Innocenti & Mark J Ratain. (2003) UGT pharmacogenomics. Pharmacogenetics 13:8, pages 517-523.
Crossref
Shufeng Zhou, Philip Kestell, Bruce C. Baguley & James W. Paxton. (2003) Preclinical factors affecting the interindividual variability in the clearance of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid. Biochemical Pharmacology 65:11, pages 1853-1865.
Crossref
Mark J Bailey & Ronald G Dickinson. (2003) Acyl glucuronide reactivity in perspective: biological consequences. Chemico-Biological Interactions 145:2, pages 117-137.
Crossref
Maria Shipkova, Victor William Armstrong, Michael Oellerich & Eberhard Wieland. (2003) Acyl Glucuronide Drug Metabolites: Toxicological and Analytical Implications. Therapeutic Drug Monitoring 25:1, pages 1-16.
Crossref
Shufeng Zhou, Philip Kestell, Bruce C Baguley & James W Paxton. (2003) Preclinical factors influencing the relative contributions of Phase I and II enzymes to the metabolism of the experimental anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid. Biochemical Pharmacology 65:1, pages 109-120.
Crossref
Shufeng Zhou, Philip Kestell & James W Paxton. (2002) Strain differences in the liver microsomal metabolism of the experimental anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid in mice. Journal of Chromatography B 776:2, pages 231-236.
Crossref
Shufeng Zhou, Philip Kestell, Bruce C. Baguley & James W. Paxton. (2002) 5,6-Dimethylxanthenone-4-Acetic Acid (DMXAA): a New Biological Response Modifier for Cancer Therapy. Investigational New Drugs 20:3, pages 281-295.
Crossref
Maria Shipkova, Victor W. Armstrong, Lutz Weber, Paul D. Niedmann, Eberhard Wieland, Jane Haley, Burkhard Tönshoff & Michael Oellerich. (2002) Pharmacokinetics and Protein Adduct Formation of the Pharmacologically Active Acyl Glucuronide Metabolite of Mycophenolic Acid in Pediatric Renal Transplant Recipients. Therapeutic Drug Monitoring 24:3, pages 390-399.
Crossref
Shufeng Zhou, Daniel Chiang, Rebecca Chin, Philip Kestell & James W Paxton. (2002) High-throughput screening of potential inhibitors for the metabolism of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid. Journal of Chromatography B 767:1, pages 19-26.
Crossref
Shufeng Zhou, Rebecca Chin, Philip Kestell, Malcolm D. Tingle & James W. Paxton. (2001) Effects of anticancer drugs on the metabolism of the anticancer drug 5,6‐dimethylxanthenone‐4‐acetic (DMXAA) by human liver microsomes. British Journal of Clinical Pharmacology 52:2, pages 129-136.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.