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Xenobiotica
the fate of foreign compounds in biological systems
Volume 31, 2001 - Issue 5
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Research Article

Metabolism of amiodarone (Part III): identification of rabbit cytochrome P450 isoforms involved in the hydroxylation of mono-N-desethylamiodarone

P. Kozlik Cardiovascular Therapy Research Unit and Clinical Pharmacology and Toxicology Division, Department of Internal Medicine, University Hospital of Zurich, Ramistrasse 100, CH-8091 Zurich, Switzerland
,
H. R. Ha Cardiovascular Therapy Research Unit and Clinical Pharmacology and Toxicology Division, Department of Internal Medicine, University Hospital of Zurich, Ramistrasse 100, CH-8091 Zurich, Switzerland
,
B. Stieger Cardiovascular Therapy Research Unit and Clinical Pharmacology and Toxicology Division, Department of Internal Medicine, University Hospital of Zurich, Ramistrasse 100, CH-8091 Zurich, Switzerland
,
L. Bigler Cardiovascular Therapy Research Unit and Clinical Pharmacology and Toxicology Division, Department of Internal Medicine, University Hospital of Zurich, Ramistrasse 100, CH-8091 Zurich, Switzerland
&
F. Follath Cardiovascular Therapy Research Unit and Clinical Pharmacology and Toxicology Division, Department of Internal Medicine, University Hospital of Zurich, Ramistrasse 100, CH-8091 Zurich, Switzerland
Pages 239-248 | Published online: 22 Sep 2008

Citations (6)

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Read on this site (2)

Katie Chan, Don Truong, Nandita Shangari & Peter J O’Brien. (2005) Drug-induced mitochondrial toxicity. Expert Opinion on Drug Metabolism & Toxicology 1:4, pages 655-669.
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Jane Delaney, William A. Neville, Aubrey Swain, Adam Miles, Michael S. Leonard & Catherine J. Waterfield. (2004) Phenylacetylglycine, a putative biomarker of phospholipidosis: Its origins and relevance to phospholipid accumulation using amiodarone treated rats as a model. Biomarkers 9:3, pages 271-290.
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Articles from other publishers (4)

Thijs H. Oude Munnink, Anna Demmer, Roel H. J. Slenter & Kris L. L. Movig. (2018) Amiodarone Rifampicin Drug–Drug Interaction Management With Therapeutic Drug Monitoring. Therapeutic Drug Monitoring 40:2, pages 159-161.
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Mark Naccarato, Deborah Yoong, Charles la Porte & Ignatius Fong. (2013) Amiodarone and Concurrent Antiretroviral Therapy: A Case Report and Review of the Literature. Antiviral Therapy 19:4, pages 329-339.
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Ninad Ramesh Varkhede, Shalu Jhajra, Deepak Suresh Ahire & Saranjit Singh. (2014) Metabolite identification studies on amiodarone in in vitro (rat liver microsomes, rat and human liver S9 fractions) and in vivo (rat feces, urine, plasma) matrices by using liquid chromatography with high-resolution mass spectrometry and multiple-stage m. Rapid Communications in Mass Spectrometry 28:4, pages 311-331.
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Qing Chen, Eugene Tan, John R. Strauss, Zhoupeng Zhang, Judith E. Fenyk-Melody, Catherine Booth-Genthe, Thomas H. Rushmore, Ralph A. Stearns, David C. Evans, Thomas A. Baillie & Wei Tang. (2004) Effect of Quinidine on the 10-Hydroxylation of R -Warfarin: Species Differences and Clearance Projection . Journal of Pharmacology and Experimental Therapeutics 311:1, pages 307-314.
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