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Xenobiotica
the fate of foreign compounds in biological systems
Volume 32, 2002 - Issue 1
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Research Article

N-O glucuronidation: a major human metabolic pathway in the elimination of two novel anticonvulsant drug candidates

I. M. Ismail Structural Identification Group, GlaxoSmithKline Research and Development, Park Road, Ware SG12 0DP, UK
,
G. J. Dear Structural Identification Group, GlaxoSmithKline, Inc., 3030 Cornwallis Road, RTP, NC 27709, USA
,
A. D. Roberts Structural Identification Group, GlaxoSmithKline Research and Development, Park Road, Ware SG12 0DP, UK
,
R. S. Plumb Structural Identification Group, GlaxoSmithKline, Inc., 3030 Cornwallis Road, RTP, NC 27709, USA
,
J. Ayrton Structural Identification Group, GlaxoSmithKline Research and Development, Park Road, Ware SG12 0DP, UK
,
B. C. Sweatman Structural Identification Group, GlaxoSmithKline, Inc., 3030 Cornwallis Road, RTP, NC 27709, USA
&
G. D. Bowers Structural Identification Group, GlaxoSmithKline Research and Development, Park Road, Ware SG12 0DP, UK
 show all
Pages 29-43 | Published online: 22 Sep 2008

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Angus N.R. Nedderman, Gordon J. Dear, Stephanie North, R. Scott Obach & David Higton. (2011) From definition to implementation: a cross-industry perspective of past, current and future MIST strategies. Xenobiotica 41:8, pages 605-622.
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F. Desmoulin, V. Gilard, M. Malet-Martino, R. Martino, C. Molina & P. Smith. (2003) Metabolism of a novel nucleoside analogue, OGT 719, in the isolated perfused rat liver model, in rats, in tumour models and in patients. Xenobiotica 33:3, pages 289-303.
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Articles from other publishers (12)

Andrew McEwen. 2020. Drug Discovery and Evaluation: Methods in Clinical Pharmacology. Drug Discovery and Evaluation: Methods in Clinical Pharmacology 773 806 .
Xingxing Diao, Jeremy Carlier, Mingshe Zhu & Marilyn A Huestis. (2017) Human Hepatocyte Metabolism of Novel Synthetic Cannabinoids MN-18 and Its 5-Fluoro Analog 5F-MN-18. Clinical Chemistry 63:11, pages 1753-1763.
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Andrew McEwen. 2017. Drug Discovery and Evaluation: Methods in Clinical Pharmacology. Drug Discovery and Evaluation: Methods in Clinical Pharmacology 1 34 .
Gordon J. Dear & Andrew McEwen. 2016. Metabolite Safety in Drug Development. Metabolite Safety in Drug Development 45 85 .
Xingxing Diao, Karl B. Scheidweiler, Ariane Wohlfarth, Mingshe Zhu, Shaokun Pang & Marilyn A. Huestis. (2016) Strategies to distinguish new synthetic cannabinoid FUBIMINA (BIM-2201) intake from its isomer THJ-2201: metabolism of FUBIMINA in human hepatocytes. Forensic Toxicology 34:2, pages 256-267.
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Xingxing Diao, Ariane Wohlfarth, Shaokun Pang, Karl B Scheidweiler & Marilyn A Huestis. (2016) High-Resolution Mass Spectrometry for Characterizing the Metabolism of Synthetic Cannabinoid THJ-018 and Its 5-Fluoro Analog THJ-2201 after Incubation in Human Hepatocytes. Clinical Chemistry 62:1, pages 157-169.
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Claire Beaumont, Graeme C. Young, Tom Cavalier & Malcolm A. Young. (2014) Human absorption, distribution, metabolism and excretion properties of drug molecules: a plethora of approaches. British Journal of Clinical Pharmacology 78:6, pages 1185-1200.
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Chester L BowenJonathan Volpatti, Jessica Cades, Hermes Licea-Perez & Christopher A Evans. (2012) Evaluation of glucuronide metabolite stability in dried blood spots. Bioanalysis 4:23, pages 2823-2832.
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John C. L. Erve, Chad E. Beyer, Lawrence Manzino & Rasmy E. Talaat. (2009) Metabolite identification in rat brain microdialysates by direct infusion nanoelectrospray ionization after desalting on a ZipTip and LTQ/Orbitrap mass spectrometry. Rapid Communications in Mass Spectrometry 23:24, pages 4003-4012.
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Sylvie Klieber, Sébastien Hugla, Robert Ngo, Catherine Arabeyre-Fabre, Viviane Meunier, Freddy Sadoun, Olivier Fedeli, Martine Rival, Martine Bourrie, François Guillou, Patrick Maurel & Gérard Fabre. (2008) Contribution of the N -Glucuronidation Pathway to the Overall in Vitro Metabolic Clearance of Midazolam in Humans . Drug Metabolism and Disposition 36:5, pages 851-862.
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William L. Fitch, Limin He, Ya-Ping Tu & Ludmila Alexandrova. (2007) Application of polarity switching in the identification of the metabolites of RO9237. Rapid Communications in Mass Spectrometry 21:10, pages 1661-1668.
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Michael Coughtrie & Michael Fisher. 2003. Drug Metabolizing Enzymes. Drug Metabolizing Enzymes 541 575 .

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