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Xenobiotica
the fate of foreign compounds in biological systems
Volume 32, 2002 - Issue 3
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Research Article

Differences in the absorption, metabolism and biliary excretion of a diastereomeric pair of α v β 3 - antagonists in rat: limited role of P-glycoprotein

T. Prueksaritanont Departments of Drug Metabolism
,
Y. Meng Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA
,
B. Ma Departments of Drug Metabolism
,
P. Leppert Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA
,
J. Hochman Departments of Drug Metabolism
,
C. Tang Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA
,
J. Perkins Departments of Drug Metabolism
,
M. Zrada Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA
,
R. Meissner Departments of Drug Metabolism
,
M.E Duggan Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA
&
J.H Lin Departments of Drug Metabolism
 show all
Pages 207-220 | Published online: 22 Sep 2008

Citations (12)

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Read on this site (5)

K. W. Ward, L. B. Hardy, J. R. Kehler, L. M. Azzarano & B. R. Smith. (2004) Apparent absolute oral bioavailability in excess of 100% for a vitronectin receptor antagonist (SB-265123) in rat. II. Studies implicating transporter-mediated intestinal secretion. Xenobiotica 34:4, pages 367-377.
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T. Prueksaritanont, C. Fernandez-Metzler, Y. Meng, A. Barrish, W. Halczenko, S. B. Rodan, J. H. Hutchinson, M. E. Duggan & J. H. Lin. (2004) Disposition of a novel and potent αvβ3 antagonist in animals, and extrapolation to man. Xenobiotica 34:1, pages 103-115.
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T. Prueksaritanont, J. H. Hochman, Y. Meng, N. T. Pudvah, A. Barrish, B. Ma, M. Yamazaki, C. Fernandez-metzler & J. H. Lin. (2004) Renal elimination of a novel and potent αvβ3 integrin antagonist in animals. Xenobiotica 34:11-12, pages 1059-1074.
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T. Prueksaritanont, X. Xu, P. Deluna, M. Yamazaki & J. H. Lin. (2003) Stereoselective hepatic disposition of a diastereomeric pair of αvβ3 antagonists in rat. Xenobiotica 33:11, pages 1125-1137.
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Remigijus Didziapetris, Pranas Japertas, Alex Avdeef & Alanas Petrauskas. (2003) Classification Analysis of P-Glycoprotein Substrate Specificity. Journal of Drug Targeting 11:7, pages 391-406.
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Articles from other publishers (7)

K. Sandy Pang, Han-Joo Maeng & Jianghong Fan. (2009) Interplay of Transporters and Enzymes in Drug and Metabolite Processing. Molecular Pharmaceutics 6:6, pages 1734-1755.
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Eva M. del Amo, Aki T. Heikkinen & Jukka M?nkk?nen. (2009) In vitro?in vivo correlation in p-glycoprotein mediated transport in intestinal absorption. European Journal of Pharmaceutical Sciences 36:2-3, pages 200-211.
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Ian M. Bell, Rodney A. Bednar, John F. Fay, Steven N. Gallicchio, Jerome H. Hochman, Daniel R. McMasters, Cynthia Miller-Stein, Eric L. Moore, Scott D. Mosser, Nicole T. Pudvah, Amy G. Quigley, Christopher A. Salvatore, Craig A. Stump, Cory R. Theberge, Bradley K. Wong, C. Blair Zartman, Xu-Fang Zhang, Stefanie A. Kane, Samuel L. Graham, Joseph P. Vacca & Theresa M. Williams. (2006) Identification of novel, orally bioavailable spirohydantoin CGRP receptor antagonists. Bioorganic & Medicinal Chemistry Letters 16:24, pages 6165-6169.
Crossref
Thomas J. Raub. (2005) P-Glycoprotein Recognition of Substrates and Circumvention through Rational Drug Design. Molecular Pharmaceutics 3:1, pages 3-25.
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Jerome Hochman, Qin Mei, Masayo Yamazaki, Cuyue Tang, Thomayant Prueksaritanont, Mark Bock, Sookhee Ha & Jiunn Lin. 2006. Optimizing the “Drug-Like” Properties of Leads in Drug Discovery. Optimizing the “Drug-Like” Properties of Leads in Drug Discovery 25 47 .
William W. Johnson. 2004. Cellular Drug Delivery. Cellular Drug Delivery 129 162 .
James J Perkins, L.T Duong, Carmen Fernandez-Metzler, George D Hartman, Donald B Kimmel, Chih-Tai Leu, Joseph J Lynch, Thomayant Prueksaritanont, Gideon A Rodan, Sevgi B Rodan, Mark E Duggan & Robert S Meissner. (2003) Non-peptide α v β 3 antagonists: Identification of potent, chain-shortened RGD mimetics that incorporate a central pyrrolidinone constraint. Bioorganic & Medicinal Chemistry Letters 13:24, pages 4285-4288.
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