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Xenobiotica
the fate of foreign compounds in biological systems
Volume 32, 2002 - Issue 3
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Research Article

SB-242235, a selective inhibitor of p38 mitogen-activated protein kinase. II: In vitro and in vivo metabolism studies and pharmacokinetic extrapolation to man

K. W. Ward Preclinical Drug Discovery, Cardiovascular, Urogenitary, and Oncology Centre for Excellence in Drug Discovery
,
J. W. Proksch Drug Metabolism and Pharmockinetics, GlaxoSmithKline R & D, King of Prussia, PA 19406, USA
,
P. D. Gorycki Drug Metabolism and Pharmockinetics, GlaxoSmithKline R & D, King of Prussia, PA 19406, USA
,
C.-P. Yu Preclinical Drug Discovery, Cardiovascular, Urogenitary, and Oncology Centre for Excellence in Drug Discovery
,
M. Y. K. Ho Drug Metabolism and Pharmockinetics, GlaxoSmithKline R & D, King of Prussia, PA 19406, USA
,
B. D. Bush Drug Metabolism and Pharmockinetics, GlaxoSmithKline R & D, King of Prussia, PA 19406, USA
,
M. A. Levy Preclinical Drug Discovery, Cardiovascular, Urogenitary, and Oncology Centre for Excellence in Drug Discovery
&
B. R. Smith Drug Metabolism and Pharmockinetics, GlaxoSmithKline R & D, King of Prussia, PA 19406, USA
 show all
Pages 235-250 | Published online: 22 Sep 2008

Citations (13)

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B. Kammerer, H. Scheible, G. Zurek, M. Godejohann, K.-P. Zeller, C. H. Gleiter, W. Albrecht & S. Laufer. (2007) In vitro metabolite identification of ML3403, a 4-pyridinylimidazole-type p38 MAP kinase inhibitor by LC-Qq-TOF-MS and LC-SPE-cryo-NMR/MS. Xenobiotica 37:3, pages 280-297.
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R. K. Bhamidipati, P. V. Dravid, R. Mullangi & N. R. Srinivas. (2004) Prediction of clinical pharmacokinetic parameters of linezolid using animal data by allometric scaling: applicability for the development of novel oxazolidinones. Xenobiotica 34:6, pages 571-579.
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Articles from other publishers (11)

Urban Fagerholm. (2007) Prediction of human pharmacokinetics—evaluation of methods for prediction of hepatic metabolic clearance. Journal of Pharmacy and Pharmacology 59:6, pages 803-828.
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Naval P. Shanware, Leah M. Williams, Michael J. Bowler & Randal S. Tibbetts. (2009) Non-specific in vivo inhibition of CK1 by the pyridinyl imidazole p38 inhibitors SB 203580 and SB 202190. BMB Reports 42:3, pages 142-147.
Crossref
Chris Logan. 2008. Drug Bioavailability. Drug Bioavailability 161 184 .
Y A Ivanenkov, K V Balakin & S E Tkachenko. (2008) New Approaches to the Treatment of Inflammatory Disease. Drugs in R & D 9:6, pages 397-434.
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Bernd Kammerer, Holger Scheible, Wolfgang Albrecht, Christoph H. Gleiter & Stefan Laufer. (2007) Pharmacokinetics of ML3403 ({4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3 H -imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-Pyridinylimidazole-Type p38 Mitogen-Activated Protein Kinase Inhibitor . Drug Metabolism and Disposition 35:6, pages 875-883.
Crossref
Arianna L. Kim, Jeffrey M. Labasi, Yucui Zhu, Xiuwei Tang, Kim McClure, Christopher A. Gabel, Mohammad Athar & David R. Bickers. (2005) Role of p38 MAPK in UVB-Induced Inflammatory Responses in the Skin of SKH-1 Hairless Mice. Journal of Investigative Dermatology 124:6, pages 1318-1325.
Crossref
Hiroe Shiratsuchi & Marc D. Basson. (2005) Activation of p38 MAPKα by extracellular pressure mediates the stimulation of macrophage phagocytosis by pressure. American Journal of Physiology-Cell Physiology 288:5, pages C1083-C1093.
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Rakesh Nagilla & Keith W. Ward. (2004) A comprehensive analysis of the role of correction factors in the allometric predictivity of clearance from rat, dog, and monkey to humans. Journal of Pharmaceutical Sciences 93:10, pages 2522-2534.
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Keith W. Ward & Brian R. Smith. (2004) A COMPREHENSIVE QUANTITATIVE AND QUALITATIVE EVALUATION OF EXTRAPOLATION OF INTRAVENOUS PHARMACOKINETIC PARAMETERS FROM RAT, DOG, AND MONKEY TO HUMANS. I. CLEARANCE. Drug Metabolism and Disposition 32:6, pages 603-611.
Crossref
Robert Newton & Neil Holden. (2003) Inhibitors of p38 Mitogen-Activated Protein Kinase. BioDrugs 17:2, pages 113-129.
Crossref
Jeremy D. Gale, Kim F. McClure & Nick Pullen. 2003. 141 152 .

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