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Xenobiotica
the fate of foreign compounds in biological systems
Volume 32, 2002 - Issue 12
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Research Article

Decreased hepatobiliary transport of methotrexate in adjuvant arthritis rats

M. Achira Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd, 2-2-50 Kawagishi Toda Saitama 335-8505, Japan
,
R. Totsuka Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd, 2-2-50 Kawagishi Toda Saitama 335-8505, Japan
,
H. Fujimura Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd, 2-2-50 Kawagishi Toda Saitama 335-8505, Japan
&
T. Kume Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd, 2-2-50 Kawagishi Toda Saitama 335-8505, Japan
Pages 1151-1160 | Published online: 22 Sep 2008

Citations (6)

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Xinsheng Gu & Jose E. Manautou. (2010) Regulation of hepatic ABCC transporters by xenobiotics and in disease states. Drug Metabolism Reviews 42:3, pages 482-538.
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Articles from other publishers (5)

Misato Uraki, Atsushi Kawase, Hiroyuki Sayama, Yuka Matsushima & Masahiro Iwaki. (2017) Effects of Adjuvant-Induced Inflammation on Disposition of Diclofenac and Its Metabolites in Perfused Rat Liver. Journal of Pharmaceutical Sciences 106:4, pages 1175-1182.
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Ridhi Parasrampuria & Reza Mehvar. (2010) Dose-Dependent Inhibition of Transporter-Mediated Hepatic Uptake and Biliary Excretion of Methotrexate by Cyclosporine A in an Isolated Perfused Rat Liver Model. Journal of Pharmaceutical Sciences 99:12, pages 5060-5069.
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Arnaud BruyèreXavier DeclèvesFrancois BouzomKathryn BallCatie MarquesXavier TretonMarc PocardPatrice ValleurYoram BouhnikYves PanisJean-Michel ScherrmannStephane Mouly. (2010) Effect of Variations in the Amounts of P-Glycoprotein (ABCB1), BCRP (ABCG2) and CYP3A4 along the Human Small Intestine on PBPK Models for Predicting Intestinal First Pass. Molecular Pharmaceutics 7:5, pages 1596-1607.
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Yen Tong, Ruhong Zhang, Suong NT Ngo & Andrew K Davey. (2006) ALTERATION OF FEXOFENADINE DISPOSITION IN THE RAT ISOLATED PERFUSED LIVER FOLLOWING INJECTION OF BACTERIAL LIPOPOLYSACCHARIDE. Clinical and Experimental Pharmacology and Physiology 33:8, pages 685-689.
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Daniel Y. Hung, Gerhard A. Siebert, Ping Chang, Michael W. Whitehouse, Linda Fletcher, Darrell H. G. Crawford & Michael S. Roberts. (2006) Hepatic pharmacokinetics of propranolol in rats with adjuvant-induced systemic inflammation. American Journal of Physiology-Gastrointestinal and Liver Physiology 290:2, pages G343-G351.
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